ENSMUSG00000039115


Mus musculus

Features
Gene ID: ENSMUSG00000039115
  
Biological name :Itga9
  
Synonyms : B8JK39 / Integrin alpha-9 / Itga9
  
Possible biological names infered from orthology : integrin subunit alpha 9 / Q13797
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F3
Gene start: 118606690
Gene end: 118901003
  
Corresponding Affymetrix probe sets: 10590031 (MoGene1.0st)   1420860_at (Mouse Genome 430 2.0 Array)   1450029_s_at (Mouse Genome 430 2.0 Array)   1460285_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122417
Ensembl peptide - ENSMUSP00000044227
Ensembl peptide - ENSMUSP00000122408
NCBI entrez gene - 104099     See in Manteia.
MGI - MGI:104756
RefSeq - XM_006511918
RefSeq - NM_001113514
RefSeq - NM_133721
RefSeq Peptide - NP_598482
RefSeq Peptide - NP_001106986
swissprot - B8JK39
swissprot - F7DB81
swissprot - E9QAP0
Ensembl - ENSMUSG00000039115
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itga9ENSDARG00000032435Danio rerio
 ITGA9ENSGALG00000029378Gallus gallus
 ITGA9ENSG00000144668Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itga4 / integrin subunit alpha 4 / P13612*ENSMUSG0000002700942
Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*ENSMUSG0000000055526
Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*ENSMUSG0000002534826
Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*ENSMUSG0000002711126
Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*ENSMUSG0000000150725
Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*ENSMUSG0000002676825
Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*ENSMUSG0000002708725
Itga11 / integrin subunit alpha 11 / Q9UKX5*ENSMUSG0000003224324
Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*ENSMUSG0000003466424
Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*ENSMUSG0000003078923
Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*ENSMUSG0000001553322
Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*ENSMUSG0000003083022
Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*ENSMUSG0000004228422
Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*ENSMUSG0000007036922
Itga10 / integrin subunit alpha 10 / O75578*ENSMUSG0000009021022
Itgam / integrin alpha M / P11215* / integrin subunit alpha M*ENSMUSG0000003078621
Itgae / Q60677 / integrin alpha E, epithelial-associated / P38570* / integrin subunit alpha E*ENSMUSG0000000594720
Itgam / P11215* / integrin subunit alpha M*ENSMUSG0000010859620


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0030593 neutrophil chemotaxis IGI
 biological_processGO:0042060 wound healing IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009925 basal plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034679 integrin alpha9-beta1 complex IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0043236 laminin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Integrin cell surface interactions
ECM proteoglycans
Signal transduction by L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc6a8tm1.1Clar/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Itga9tm1Des/Itga9+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0002132 abnormal respiratory system morphology "anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a8tm1.1Clar/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Itga9tm2Des/Itga9tm2Des
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a8tm1.1Clar/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Itga9tm2Des/Itga9tm2Des
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(Tcrb)93Vbo/0
Genetic Background: involves: C57BL/Lia * CB17 * CBA/BrA

 MP:0003659 abnormal lymph circulation "abnormalities in the flow of the lymph from the tissues into the veins of the circulatory system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95885]
Show

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0003660 chylothorax "an accumulation of chyle (fluid consisting of lymph and emulsified fats that is formed in the small intestine during digestion of fatty foods and taken up by the lymph vessels) in the thoracic cavity" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95585]
Show

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gabra1tm1Geh/Gabra1tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005543 corneal thinning "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gabra1tm1Geh/Gabra1tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabra1tm1Geh/Gabra1tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028364 Tnc / Q80YX1 / tenascin C / P24821*  / complex / reaction
 ENSMUSG00000029304 Spp1 / P10923 / secreted phosphoprotein 1 / P10451*  / complex / reaction
 ENSMUSG00000027962 Vcam1 / P29533 / vascular cell adhesion molecule 1 / P19320*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex






 

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