ENSMUSG00000015533


Mus musculus

Features
Gene ID: ENSMUSG00000015533
  
Biological name :Itga2
  
Synonyms : Integrin alpha-2 / Itga2 / Q62469
  
Possible biological names infered from orthology : integrin subunit alpha 2 / P17301
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D2.2
Gene start: 114833081
Gene end: 114932100
  
Corresponding Affymetrix probe sets: 10412267 (MoGene1.0st)   1442350_at (Mouse Genome 430 2.0 Array)   1450501_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153056
Ensembl peptide - ENSMUSP00000053891
NCBI entrez gene - 16398     See in Manteia.
MGI - MGI:96600
RefSeq - NM_008396
RefSeq Peptide - NP_032422
swissprot - A0A286YCM1
swissprot - Q62469
Ensembl - ENSMUSG00000015533
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itga2.2ENSDARG00000062974Danio rerio
 ITGA2ENSGALG00000014903Gallus gallus
 ITGA2ENSG00000164171Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*ENSMUSG0000004228439
Itga11 / integrin subunit alpha 11 / Q9UKX5*ENSMUSG0000003224336
Itga10 / integrin subunit alpha 10 / O75578*ENSMUSG0000009021033
Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*ENSMUSG0000003078927
Itgam / integrin alpha M / P11215* / integrin subunit alpha M*ENSMUSG0000003078626
Itgam / P11215* / integrin subunit alpha M*ENSMUSG0000010859626
Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*ENSMUSG0000003083025
Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*ENSMUSG0000007036925
Itgae / Q60677 / integrin alpha E, epithelial-associated / P38570* / integrin subunit alpha E*ENSMUSG0000000594724
Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*ENSMUSG0000000150719
Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*ENSMUSG0000002534819
Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*ENSMUSG0000002676819
Itga4 / integrin subunit alpha 4 / P13612*ENSMUSG0000002700919
Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*ENSMUSG0000002708719
Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*ENSMUSG0000003911519
Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*ENSMUSG0000000055518
Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*ENSMUSG0000002711118
Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*ENSMUSG0000003466418


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR002035  von Willebrand factor, type A
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002687 positive regulation of leukocyte migration IEA
 biological_processGO:0006929 substrate-dependent cell migration IEA
 biological_processGO:0006971 hypotonic response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway ISO
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010694 positive regulation of alkaline phosphatase activity IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014075 response to amine IEA
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0031346 positive regulation of cell projection organization IEA
 biological_processGO:0031589 cell-substrate adhesion IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0033343 positive regulation of collagen binding IEA
 biological_processGO:0033591 response to L-ascorbic acid IEA
 biological_processGO:0033627 cell adhesion mediated by integrin IEA
 biological_processGO:0038065 collagen-activated signaling pathway IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043589 skin morphogenesis IEA
 biological_processGO:0045184 establishment of protein localization IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0048041 focal adhesion assembly IEA
 biological_processGO:0048333 mesodermal cell differentiation IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050927 positive regulation of positive chemotaxis IEA
 biological_processGO:0050966 detection of mechanical stimulus involved in sensory perception of pain IEA
 biological_processGO:0051971 positive regulation of transmission of nerve impulse IEA
 biological_processGO:0060100 positive regulation of phagocytosis, engulfment IEA
 biological_processGO:0070365 hepatocyte differentiation IEA
 biological_processGO:0071107 response to parathyroid hormone IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0034666 integrin alpha2-beta1 complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0045178 basal part of cell IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001540 amyloid-beta binding IDA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0038064 collagen receptor activity IEA
 molecular_functionGO:0043236 laminin binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0098639 collagen binding involved in cell-matrix adhesion IEA


Pathways (from Reactome)
Pathway description
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1+,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: RpgrRd9/Y
Genetic Background: C57BL/6-RpgrRd9

Allelic Composition: Itga2tm1.1Tkun/Itga2tm1.1Tkun
Genetic Background: B6.Cg-Itga2tm1.1Tkun/J

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1+,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Allelic Composition: Itga2tm1Ztr/Itga2tm1Ztr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hoxc8tm1.1Rud/Hoxc8tm1.1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Itga2tm1Ztr/Itga2tm1Ztr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itga2tm1.1Eck/Itga2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Itga2tm1.1Tkun/Itga2tm1.1Tkun,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008935 decreased mean platelet volume "reduced average content of platelet cells over normal" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Itga2tm1.1Tkun/Itga2tm1.1Tkun,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009548 abnormal platelet aggregation "any functional anomaly in the adhesion of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Hoxc8tm1.1Rud/Hoxc8tm1.1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Hoxc8tm1.1Rud/Hoxc8tm1.1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Itga2tm1.1Eck/Itga2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Itga2tm1.1Tkun/Itga2tm1.1Tkun,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026639 Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*  / complex / reaction
 ENSMUSG00000026479 Lamc2 / laminin subunit gamma 2 / Q13753*  / complex / reaction
 ENSMUSG00000028763 Hspg2 / perlecan (heparan sulfate proteoglycan 2) / P98160* / heparan sulfate proteoglycan 2*  / complex / reaction
 ENSMUSG00000036446 Lum / P51885 / Lumican / P51884*  / complex / reaction
 ENSMUSG00000030077 Chl1 / P70232 / Neural cell adhesion molecule L1-like protein Processed neural cell adhesion molecule L1-like protein / O00533* / cell adhesion molecule L1 like*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex
 ENSMUSG00000024421 Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*  / complex / reaction






 

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