Manteia

ENSG00000164171

Homo sapiens

Features

Gene ID:	ENSG00000164171

Biological name :	ITGA2

Synonyms :	integrin subunit alpha 2 / ITGA2 / P17301

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	5
Strand:	1
Band:	q11.2
Gene start:	52989326
Gene end:	53094779

Corresponding Affymetrix probe sets:	205032_at (Human Genome U133 Plus 2.0 Array) 227314_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000424642 Ensembl peptide - ENSP00000422095 Ensembl peptide - ENSP00000426489 Ensembl peptide - ENSP00000296585 Ensembl peptide - ENSP00000424397 Ensembl peptide - ENSP00000422145 NCBI entrez gene - 3673 See in Manteia. OMIM - 192974 RefSeq - NM_002203 RefSeq Peptide - NP_002194 swissprot - E7EMF1 swissprot - D6RG08 swissprot - D6R9H3 swissprot - E9PB77 swissprot - P17301 swissprot - E7ESP4 Ensembl - ENSG00000164171

Related genetic diseases (OMIM):	614200 - ?Glycoprotein Ia deficiency, 614200

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
itga2.2	ENSDARG00000062974	Danio rerio
ITGA2	ENSGALG00000014903	Gallus gallus
Itga2	ENSMUSG00000015533	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
ITGA1 / P56199 / integrin subunit alpha 1	ENSG00000213949	40
ITGA11 / Q9UKX5 / integrin subunit alpha 11	ENSG00000137809	34
ITGA10 / O75578 / integrin subunit alpha 10	ENSG00000143127	33
ITGAX / P20702 / integrin subunit alpha X	ENSG00000140678	27
ITGAD / Q13349 / integrin subunit alpha D	ENSG00000156886	25
ITGAM / P11215 / integrin subunit alpha M	ENSG00000169896	25
ITGAL / P20701 / integrin subunit alpha L	ENSG00000005844	24
ITGAE / P38570 / integrin subunit alpha E	ENSG00000083457	24
ITGA8 / P53708 / integrin subunit alpha 8	ENSG00000077943	20
ITGA2B / P08514 / integrin subunit alpha 2b	ENSG00000005961	19
ITGA6 / P23229 / integrin subunit alpha 6	ENSG00000091409	19
ITGA4 / P13612 / integrin subunit alpha 4	ENSG00000115232	19
ITGA7 / Q13683 / integrin subunit alpha 7	ENSG00000135424	19
ITGAV / P06756 / integrin subunit alpha V	ENSG00000138448	19
ITGA9 / Q13797 / integrin subunit alpha 9	ENSG00000144668	19
ITGA5 / P08648 / integrin subunit alpha 5	ENSG00000161638	19
ITGA3 / P26006 / integrin subunit alpha 3	ENSG00000005884	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR000413	Integrin alpha chain
IPR002035	von Willebrand factor, type A
IPR013517	FG-GAP repeat
IPR013519	Integrin alpha beta-propellor
IPR013649	Integrin alpha-2
IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site
IPR032695	Integrin domain superfamily
IPR036465	von Willebrand factor A-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001666	response to hypoxia	IEA
biological_process	GO:0002687	positive regulation of leukocyte migration	IEA
biological_process	GO:0006929	substrate-dependent cell migration	IMP
biological_process	GO:0006971	hypotonic response	IEA
biological_process	GO:0007155	cell adhesion	IEA
biological_process	GO:0007160	cell-matrix adhesion	TAS
biological_process	GO:0007229	integrin-mediated signaling pathway	IEA
biological_process	GO:0007565	female pregnancy	IEA
biological_process	GO:0007596	blood coagulation	TAS
biological_process	GO:0008283	cell proliferation	IEA
biological_process	GO:0009887	animal organ morphogenesis	TAS
biological_process	GO:0010634	positive regulation of epithelial cell migration	IEA
biological_process	GO:0010694	positive regulation of alkaline phosphatase activity	IEA
biological_process	GO:0014070	response to organic cyclic compound	IEA
biological_process	GO:0014075	response to amine	IEA
biological_process	GO:0014850	response to muscle activity	IEA
biological_process	GO:0014911	positive regulation of smooth muscle cell migration	IEA
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0030198	extracellular matrix organization	TAS
biological_process	GO:0030879	mammary gland development	IEA
biological_process	GO:0031346	positive regulation of cell projection organization	IEA
biological_process	GO:0031589	cell-substrate adhesion	IMP
biological_process	GO:0032967	positive regulation of collagen biosynthetic process	IEA
biological_process	GO:0033343	positive regulation of collagen binding	IEA
biological_process	GO:0033591	response to L-ascorbic acid	IEA
biological_process	GO:0033627	cell adhesion mediated by integrin	IMP
biological_process	GO:0038065	collagen-activated signaling pathway	IMP
biological_process	GO:0042060	wound healing	IEA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0043388	positive regulation of DNA binding	IEA
biological_process	GO:0043589	skin morphogenesis	IEA
biological_process	GO:0045184	establishment of protein localization	IEA
biological_process	GO:0045727	positive regulation of translation	IEA
biological_process	GO:0045785	positive regulation of cell adhesion	IEA
biological_process	GO:0045987	positive regulation of smooth muscle contraction	IEA
biological_process	GO:0046718	viral entry into host cell	IEA
biological_process	GO:0048041	focal adhesion assembly	IEA
biological_process	GO:0048333	mesodermal cell differentiation	IEP
biological_process	GO:0048661	positive regulation of smooth muscle cell proliferation	IEA
biological_process	GO:0050729	positive regulation of inflammatory response	IEA
biological_process	GO:0050927	positive regulation of positive chemotaxis	IEA
biological_process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	IEA
biological_process	GO:0051971	positive regulation of transmission of nerve impulse	IEA
biological_process	GO:0060100	positive regulation of phagocytosis, engulfment	IEA
biological_process	GO:0070365	hepatocyte differentiation	IEA
biological_process	GO:0071107	response to parathyroid hormone	IEA
biological_process	GO:0071260	cellular response to mechanical stimulus	IEA
biological_process	GO:0071392	cellular response to estradiol stimulus	IEA
biological_process	GO:0071407	cellular response to organic cyclic compound	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005925	focal adhesion	IEA
cellular_component	GO:0008305	integrin complex	IEA
cellular_component	GO:0009897	external side of plasma membrane	IEA
cellular_component	GO:0009986	cell surface	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030424	axon	IEA
cellular_component	GO:0034666	integrin alpha2-beta1 complex	IDA
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:0043679	axon terminus	IEA
cellular_component	GO:0045178	basal part of cell	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	IEA
molecular_function	GO:0001540	amyloid-beta binding	IEA
molecular_function	GO:0001618	virus receptor activity	IEA
molecular_function	GO:0005178	integrin binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005518	collagen binding	IEA
molecular_function	GO:0038064	collagen receptor activity	IMP
molecular_function	GO:0043236	laminin binding	IEA
molecular_function	GO:0043395	heparan sulfate proteoglycan binding	TAS
molecular_function	GO:0044877	protein-containing complex binding	IPI
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0046982	protein heterodimerization activity	IEA
molecular_function	GO:0098639	collagen binding involved in cell-matrix adhesion	IMP

Pathways (from Reactome)

Pathway description

Integrin cell surface interactions

Laminin interactions

Syndecan interactions

ECM proteoglycans

CHL1 interactions

Platelet Adhesion to exposed collagen

MET activates PTK2 signaling

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
HP:0000006	Autosomal dominant inheritance	"A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]	Show
HP:0000978	Ecchymoses		Show
HP:0001873	Thrombocytopenia		Show
HP:0003577	Onset at birth		Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000139329	LUM / P51884 / lumican	/ complex / reaction
ENSG00000058085	LAMC2 / Q13753 / laminin subunit gamma 2	/ complex / reaction
ENSG00000134121	CHL1 / O00533 / cell adhesion molecule L1 like	/ complex / reaction
ENSG00000150093	ITGB1 / P05556 / integrin subunit beta 1	/ complex
ENSG00000142798	HSPG2 / P98160 / heparan sulfate proteoglycan 2	/ complex / reaction
ENSG00000053747	LAMA3 / Q16787 / laminin subunit alpha 3	/ complex / reaction
ENSG00000196878	LAMB3 / Q13751 / laminin subunit beta 3	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr