ENSMUSG00000036446


Mus musculus

Features
Gene ID: ENSMUSG00000036446
  
Biological name :Lum
  
Synonyms : Lum / Lumican / P51885
  
Possible biological names infered from orthology : P51884
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C3
Gene start: 97565128
Gene end: 97572703
  
Corresponding Affymetrix probe sets: 10365983 (MoGene1.0st)   1423607_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040877
NCBI entrez gene - 17022     See in Manteia.
MGI - MGI:109347
RefSeq - NM_008524
RefSeq Peptide - NP_032550
swissprot - P51885
Ensembl - ENSMUSG00000036446
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lumENSDARG00000045580Danio rerio
 LUMENSGALG00000011271Gallus gallus
 LUMENSG00000139329Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fmod / P50608 / Fibromodulin / Q06828*ENSMUSG0000004155946
Omd / O35103 / Osteomodulin / Q99983*ENSMUSG0000004836839
Prelp / Q9JK53 / proline arginine-rich end leucine-rich repeat / P51888* / proline and arginine rich end leucine rich repeat protein*ENSMUSG0000004157738
Kera / O35367 / Keratocan / O60938*ENSMUSG0000001993237
Dcn / P28654 / Decorin / P07585*ENSMUSG0000001992931
Aspn / Q99MQ4 / Asporin / Q9BXN1*ENSMUSG0000002138830
Bgn / P28653 / biglycan / P21810*ENSMUSG0000003137530
Ecm2 / Q5FW85 / Extracellular matrix protein 2 / O94769*ENSMUSG0000004363127
Podnl1 / Q6P3Y9 / Podocan-like protein 1 / Q6PEZ8* / podocan like 1*ENSMUSG0000001288925
Podn / Q7TQ62 / podocan / Q7Z5L7*ENSMUSG0000002860025


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027219  Lumican
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0032914 positive regulation of transforming growth factor beta1 production IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0070848 response to growth factor IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005583 fibrillar collagen trimer IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005518 collagen binding IEA


Pathways (from Reactome)
Pathway description
Keratan sulfate biosynthesis
Keratan sulfate degradation
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lumtm1Wwk/Lumtm1Wwk
Genetic Background: involves: 129P2/OlaHsd

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnj6tm1Stf/Kcnj6wv
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Lumtm1Wwk/Lumtm1Wwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnj6tm1Stf/Kcnj6wv
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnj6tm1Stf/Kcnj6wv
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Lumtm1Wwk/Lumtm1Wwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ajl85/a
Genetic Background: Not Specified

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0002697 abnormal eye size "anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002698 abnormal sclera morphology "structural anomaly of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kiss1rtm1.1(KOMP)Vlcg/Kiss1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Kiss1rtm1.1(KOMP)Vlcg/Ucd

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Lumtm1Wwk/Lumtm1Wwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003092 reduced corneal stroma thickness "reduced width of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

 MP:0003094 abnormal posterior stroma morphology "structural anomaly of the posterior segment of the lamellated connective tissue layer of the cornea" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Lumtm1Wwk/Lumtm1Wwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003095 abnormal corneal stroma development "anomalous differentiaton of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

 MP:0003096 increased corneal light-scattering "anomaly in the normal transmission of light through the cornea; light is reflected or absorbed instead; often due to anomalies in the arrangement of lamella in the corneal stroma" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, J:81616]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

 MP:0003098 reduced tendon stiffness "decreased ability of tendon to maintain tensile strength and load" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:79915]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lum+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003099 retinal detachment "detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003101 high myopia "an optical condition involving enlarging of the eye, scleral thinning and frequent detachment of the retina resulting from stress associated with excessive axial elongation" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003102 sclera thinning "reduction in the width of the fibrous, outer envelope of the eyeball, the sclera may appear blue as a result of the underlying epithelium showing through" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005300 abnormal corneal stroma morphology "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

 MP:0005353 abnormal patella morphology "anomalous structure of the large sesamoid bone that covers the anterior surface of the knee" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005421 loose skin "condition in which the skin hangs in folds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005503 abnormal tendon morphology "structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005543 corneal thinning "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lumtm1Wwk/Lumtm1Wwk
Genetic Background: involves: 129P2/OlaHsd

 MP:0006433 abnormal articular cartilage morphology "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009275 bruising "an injury to biological tissue in which the capillaries are damaged, allowing blood to seep into the surrounding tissue; it should not be confused with ecchymosis, though the terms are related" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015533 Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr