ENSMUSG00000021388


Mus musculus

Features
Gene ID: ENSMUSG00000021388
  
Biological name :Aspn
  
Synonyms : Aspn / Asporin / Q99MQ4
  
Possible biological names infered from orthology : Q9BXN1
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A5
Gene start: 49544443
Gene end: 49567565
  
Corresponding Affymetrix probe sets: 10405047 (MoGene1.0st)   1416652_at (Mouse Genome 430 2.0 Array)   1448421_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021820
Ensembl peptide - ENSMUSP00000136728
NCBI entrez gene - 66695     See in Manteia.
MGI - MGI:1913945
RefSeq - NM_001172481
RefSeq - NM_025711
RefSeq Peptide - NP_001165952
RefSeq Peptide - NP_079987
swissprot - Q99MQ4
swissprot - A6H6K1
Ensembl - ENSMUSG00000021388
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aspnENSDARG00000002192Danio rerio
 ASPNENSGALG00000004722Gallus gallus
 ASPNENSG00000106819Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bgn / P28653 / biglycan / P21810*ENSMUSG0000003137552
Dcn / P28654 / Decorin / P07585*ENSMUSG0000001992947
Lum / P51885 / Lumican / P51884*ENSMUSG0000003644628
Prelp / Q9JK53 / proline arginine-rich end leucine-rich repeat / P51888* / proline and arginine rich end leucine rich repeat protein*ENSMUSG0000004157725
Kera / O35367 / Keratocan / O60938*ENSMUSG0000001993224
Fmod / P50608 / Fibromodulin / Q06828*ENSMUSG0000004155924
Ecm2 / Q5FW85 / Extracellular matrix protein 2 / O94769*ENSMUSG0000004363124
Podn / Q7TQ62 / podocan / Q7Z5L7*ENSMUSG0000002860023
Omd / O35103 / Osteomodulin / Q99983*ENSMUSG0000004836823
Podnl1 / Q6P3Y9 / Podocan-like protein 1 / Q6PEZ8* / podocan like 1*ENSMUSG0000001288922


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR016352  Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
 IPR028548  Asporin
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0031214 biomineral tissue development IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070171 negative regulation of tooth mineralization IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0046930 pore complex IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0015288 porin activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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