ENSMUSG00000031375


Mus musculus

Features
Gene ID: ENSMUSG00000031375
  
Biological name :Bgn
  
Synonyms : Bgn / biglycan / P28653
  
Possible biological names infered from orthology : P21810
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.3
Gene start: 73483602
Gene end: 73495933
  
Corresponding Affymetrix probe sets: 10600169 (MoGene1.0st)   1416405_at (Mouse Genome 430 2.0 Array)   1437889_x_at (Mouse Genome 430 2.0 Array)   1448323_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033741
Ensembl peptide - ENSMUSP00000126768
NCBI entrez gene - 12111     See in Manteia.
MGI - MGI:88158
RefSeq - XM_006527758
RefSeq - NM_007542
RefSeq Peptide - NP_031568
swissprot - P28653
swissprot - Q3TNY9
Ensembl - ENSMUSG00000031375
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bgnaENSDARG00000017884Danio rerio
 bgnbENSDARG00000002945Danio rerio
 BGNENSG00000182492Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dcn / P28654 / Decorin / P07585*ENSMUSG0000001992954
Aspn / Q99MQ4 / Asporin / Q9BXN1*ENSMUSG0000002138852
Lum / P51885 / Lumican / P51884*ENSMUSG0000003644628
Prelp / Q9JK53 / proline arginine-rich end leucine-rich repeat / P51888* / proline and arginine rich end leucine rich repeat protein*ENSMUSG0000004157727
Fmod / P50608 / Fibromodulin / Q06828*ENSMUSG0000004155925
Ecm2 / Q5FW85 / Extracellular matrix protein 2 / O94769*ENSMUSG0000004363125
Kera / O35367 / Keratocan / O60938*ENSMUSG0000001993224
Podn / Q7TQ62 / podocan / Q7Z5L7*ENSMUSG0000002860024
Omd / O35103 / Osteomodulin / Q99983*ENSMUSG0000004836824
Podnl1 / Q6P3Y9 / Podocan-like protein 1 / Q6PEZ8* / podocan like 1*ENSMUSG0000001288923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR016352  Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
 IPR028547  Biglycan
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IDA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0030133 transport vesicle ISO
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0042383 sarcolemma IDA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005539 glycosaminoglycan binding IDA
 molecular_functionGO:0050840 extracellular matrix binding IDA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
ECM proteoglycans


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
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Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001244 thin dermal layer "reduced thickness of the dermis" [J:65030]
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Bgntm1Mfy/Y
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy
Genetic Background: involves: 129S4/SvJae

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002294 short gestation period "decrease in the average duration of a pregnancy " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
Show

Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0003098 reduced tendon stiffness "decreased ability of tendon to maintain tensile strength and load" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:79915]
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
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Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy
Genetic Background: involves: 129S4/SvJae

 MP:0004126 thin hypodermis "reduced thickness of the innermost and thickest layer of the skin composed of loose connective tissue containing adipoctyes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005503 abnormal tendon morphology "structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006433 abnormal articular cartilage morphology "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0008151 increased diameter of long bones "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Bgntm1Mfy/Y
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0010962 decreased compact bone mass 
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0011642 abnormal bone collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Bgntm1Mfy/Y
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0011643 abnormal tendon collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Bgntm1Mfy/Y
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0012008 delayed parturition "the process of labor and delivery in female animals occurs later in gestation than expected or lack of progress in a labor already initiated" [MGI:csmith]
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Allelic Composition: Bgntm1Mfy/Bgn+,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0012009 early parturition "the process of labor and delivery in female animals occurs earlier in gestation than expected" [MGI:csmith]
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Bgntm1Mfy/Bgn+,Dcntm1Ioz/Dcntm1Ioz
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0013304 osteophytes "bony projections that form along joint margins at bone edges, including the spine; these are frequently found in areas affected by arthritis such as the disc or joint spaces where cartilage has deteriorated" [MGI:mlaw]
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0014101 decreased chondrocyte proliferation "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0020254 decreased collagen level "decreased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy
Genetic Background: involves: 129S4/SvJae

 MP:0030332 accelerated temporomandibular joint osteoarthritis "earlier onset or more rapid progression of a degenerative condition of the temporomandibular joint that results from breakdown of joint cartilage and underlying bone; erosive lesions and joint space narrowing usually indicate acute or early changes, whereas sclerosis, flattening, subchondral cysts, and osteophytes may indicate late changes" [http://www.sciencedirect.com/science/article/pii/S2319417016301536, MGI:anna]
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Fmodtm1Aol/Fmodtm1Aol
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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