MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0000066 | osteoporosis | "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0000130 | abnormal cancellous bone morphology | "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0000131 | abnormal long bone epiphysis morphology | "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0000133 | abnormal long bone metaphysis morphology | "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0000135 | reduced cortical bone thickness | "thinner than normal superficial layer of compact bone " [J:61509] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0000458 | abnormal mandible morphology | "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000559 | abnormal femur morphology | "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0001244 | thin dermal layer | "reduced thickness of the dermis" [J:65030] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Bgntm1Mfy/Y Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Bgntm1Mfy/Bgntm1Mfy Genetic Background: involves: 129S4/SvJae
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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MP:0001923 | reduced female fertility | "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0002081 | perinatal lethality | "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0002294 | short gestation period | "decrease in the average duration of a pregnancy " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0002932 | abnormal joint | "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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MP:0003089 | reduced skin tensile strength | "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0003098 | reduced tendon stiffness | "decreased ability of tendon to maintain tensile strength and load" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:79915] |
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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MP:0003109 | short femur | "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
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MP:0003560 | osteoarthritis | "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Bgntm1Mfy/Bgntm1Mfy Genetic Background: involves: 129S4/SvJae
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MP:0004126 | thin hypodermis | "reduced thickness of the innermost and thickest layer of the skin composed of loose connective tissue containing adipoctyes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0004214 | abnormal long bone diaphysis morphology | "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0004686 | decreased length of long bones | "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0004989 | decreased osteoblast cell number | "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0005503 | abnormal tendon morphology | "structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509] |
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0006433 | abnormal articular cartilage morphology | "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0008151 | increased diameter of long bones | "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0008271 | abnormal bone ossification | "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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MP:0008438 | abnormal cutaneous collagen fibril morphology | "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Bgntm1Mfy/Y Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0010124 | decreased bone mineral content | "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0010873 | decreased trabecular bone mass | "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0010962 | decreased compact bone mass | |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0011642 | abnormal bone collagen fibril morphology | "any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Bgntm1Mfy/Y Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0011643 | abnormal tendon collagen fibril morphology | "any structural anomaly of the connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith] |
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Allelic Composition: Thrbtm1Df/Thrbtm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Bgntm1Mfy/Y Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0012008 | delayed parturition | "the process of labor and delivery in female animals occurs later in gestation than expected or lack of progress in a labor already initiated" [MGI:csmith] |
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Allelic Composition: Bgntm1Mfy/Bgn+,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0012009 | early parturition | "the process of labor and delivery in female animals occurs earlier in gestation than expected" [MGI:csmith] |
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Bgntm1Mfy/Bgn+,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0013304 | osteophytes | "bony projections that form along joint margins at bone edges, including the spine; these are frequently found in areas affected by arthritis such as the disc or joint spaces where cartilage has deteriorated" [MGI:mlaw] |
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
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MP:0014101 | decreased chondrocyte proliferation | "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988] |
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0020254 | decreased collagen level | "decreased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682] |
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Epyctm1Mhok/Epyctm1Mhok Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Bgntm1Mfy/Bgntm1Mfy Genetic Background: involves: 129S4/SvJae
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MP:0030332 | accelerated temporomandibular joint osteoarthritis | "earlier onset or more rapid progression of a degenerative condition of the temporomandibular joint that results from breakdown of joint cartilage and underlying bone; erosive lesions and joint space narrowing usually indicate acute or early changes, whereas sclerosis, flattening, subchondral cysts, and osteophytes may indicate late changes" [http://www.sciencedirect.com/science/article/pii/S2319417016301536, MGI:anna] |
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Allelic Composition: Bgntm1Mfy/Y,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Fmodtm1Aol/Fmodtm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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