ENSMUSG00000030077


Mus musculus

Features
Gene ID: ENSMUSG00000030077
  
Biological name :Chl1
  
Synonyms : Chl1 / Neural cell adhesion molecule L1-like protein Processed neural cell adhesion molecule L1-like protein / P70232
  
Possible biological names infered from orthology : cell adhesion molecule L1 like / O00533
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E1
Gene start: 103510586
Gene end: 103750211
  
Corresponding Affymetrix probe sets: 10540298 (MoGene1.0st)   1417795_at (Mouse Genome 430 2.0 Array)   1435190_at (Mouse Genome 430 2.0 Array)   1443713_at (Mouse Genome 430 2.0 Array)   1447036_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063933
Ensembl peptide - ENSMUSP00000144739
Ensembl peptide - ENSMUSP00000144758
Ensembl peptide - ENSMUSP00000145026
Ensembl peptide - ENSMUSP00000144725
NCBI entrez gene - 12661     See in Manteia.
MGI - MGI:1098266
RefSeq - XM_017321377
RefSeq - XM_006505473
RefSeq - XM_011241198
RefSeq - XM_017321375
RefSeq - XM_017321376
RefSeq - NM_007697
RefSeq - XM_006505467
RefSeq - XM_006505468
RefSeq - XM_006505469
RefSeq - XM_006505470
RefSeq - XM_006505471
RefSeq - XM_006505472
RefSeq Peptide - NP_031723
swissprot - A0A0N4SUM4
swissprot - A0A0N4SUL1
swissprot - P70232
Ensembl - ENSMUSG00000030077
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chl1aENSDARG00000077881Danio rerio
 chl1bENSDARG00000103109Danio rerio
 CHL1ENSGALG00000037856Gallus gallus
 CHL1ENSG00000134121Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nrcam / Q810U4 / Neuronal cell adhesion molecule / Q92823*ENSMUSG0000002059842
L1cam / L1 cell adhesion molecule / P32004*ENSMUSG0000003139140
Nfasc / Q810U3 / Neurofascin / O94856*ENSMUSG0000002644236
Cntn3 / Q07409 / Contactin-3 / Q9P232*ENSMUSG0000003007523
Cntn5 / P68500 / Contactin-5 / O94779*ENSMUSG0000003948823
Cntn2 / Q61330 / Contactin-2 / Q02246*ENSMUSG0000005302422
Cntn1 / P12960 / Mus musculus contactin 1 (Cntn1), transcript variant 4, mRNA. / Q12860* / contactin 1*ENSMUSG0000005502222
Cntn4 / Q69Z26 / Contactin-4 / Q8IWV2*ENSMUSG0000006429322
Cntn6 / Q9JMB8 / Contactin-6 / Q9UQ52*ENSMUSG0000003009221


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR026966  Neurofascin/L1/NrCAM, C-terminal domain
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031103 axon regeneration IEA
 biological_processGO:0031175 neuron projection development IDA
 biological_processGO:0035640 exploration behavior IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IDA
 biological_processGO:0050890 cognition IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk,Crygsrncat/Crygs+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Kunming

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
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Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Chl1tm1Mtg/Chl1tm1Mtg
Genetic Background: B6.129P2-Chl1tm1Mtg

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk,Crygsrncat/Crygs+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Kunming

 MP:0003894 abnormal Purkinje cell innervation "malformation or absence of the supply of nerve fibers that connect to the Purkinje cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1.1Mro/Ptentm1.1Mro
Genetic Background: involves: BALB/cJ

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1.1Mro/Ptentm1.1Mro
Genetic Background: involves: BALB/cJ

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1.1Mro/Ptentm1.1Mro
Genetic Background: involves: BALB/cJ

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1.1Mro/Ptentm1.1Mro
Genetic Background: involves: BALB/cJ

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
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Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Chl1tm1Mtg/Chl1tm1Mtg
Genetic Background: B6.129P2-Chl1tm1Mtg

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk,Crygsrncat/Crygs+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Kunming

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chl1tm1Mtg/Chl1tm1Mtg
Genetic Background: B6.129P2-Chl1tm1Mtg

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
Show

Allelic Composition: Ptentm1.1Mro/Ptentm1.1Mro
Genetic Background: involves: BALB/cJ

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Chl1tm1Mtg/Chl1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0012014 abnormal olfactory neuron innervation pattern "any changes in the placement, morphology or number of axons from olfactory neurons to an effector tissue or to olfactory glomeruli or olfactory bulb" [MGI:csmith]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Chl1tm1Mtg/Chl1tm1Mtg
Genetic Background: B6.129P2-Chl1tm1Mtg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / complex / reaction
 ENSMUSG00000024966 Stip1 / Q60864 / Stress-induced-phosphoprotein 1 / P31948*  / complex / reaction
 ENSMUSG00000015533 Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*  / complex / reaction
 ENSMUSG00000042284 Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction
 ENSMUSG00000030092 Cntn6 / Q9JMB8 / Contactin-6 / Q9UQ52*  / complex / reaction






 

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