Manteia

ENSG00000077238

Homo sapiens

Features

Gene ID:	ENSG00000077238

Biological name :	IL4R

Synonyms :	IL4R / interleukin 4 receptor / P24394

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	16
Strand:	1
Band:	p12.1
Gene start:	27313668
Gene end:	27364778

Corresponding Affymetrix probe sets:	203233_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000461607 Ensembl peptide - ENSP00000461268 Ensembl peptide - ENSP00000486645 Ensembl peptide - ENSP00000170630 Ensembl peptide - ENSP00000379111 Ensembl peptide - ENSP00000441667 Ensembl peptide - ENSP00000454684 Ensembl peptide - ENSP00000454725 Ensembl peptide - ENSP00000455632 Ensembl peptide - ENSP00000455714 Ensembl peptide - ENSP00000456248 Ensembl peptide - ENSP00000456669 Ensembl peptide - ENSP00000456930 Ensembl peptide - ENSP00000457131 NCBI entrez gene - 3566 See in Manteia. OMIM - 147781 RefSeq - XM_017023211 RefSeq - NM_001257406 RefSeq - NM_001257407 RefSeq - NM_001257997 RefSeq - XM_011545825 RefSeq - XM_011545826 RefSeq - XM_011545827 RefSeq - XM_011545828 RefSeq - XM_011545829 RefSeq - XM_011545830 RefSeq - XM_011545831 RefSeq - XM_011545832 RefSeq - XM_011545833 RefSeq - XM_011545834 RefSeq - NM_000418 RefSeq Peptide - NP_001244336 RefSeq Peptide - NP_001244926 RefSeq Peptide - NP_000409 RefSeq Peptide - NP_001244335 swissprot - I3L4W9 swissprot - J9JII2 swissprot - H3BRH7 swissprot - P24394 swissprot - Q5FC08 swissprot - A0A0G2JLA1 swissprot - H3BSE7 swissprot - H3BTD9 swissprot - I3L4H7 Ensembl - ENSG00000077238

Related genetic diseases (OMIM):	147050 - {Atopy, susceptibility to}, 147050
	609423 - {AIDS, slow progression to}, 609423

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
	ENSGALG00000035447	Gallus gallus
Il4ra	ENSMUSG00000030748	Mus musculus

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR003531	Short hematopoietin receptor, family 1, conserved site
IPR003961	Fibronectin type III
IPR013783	Immunoglobulin-like fold
IPR015319	Interleukin-4 receptor alpha, N-terminal
IPR036116	Fibronectin type III superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0002532	production of molecular mediator involved in inflammatory response	IEA
biological_process	GO:0002639	positive regulation of immunoglobulin production	IEA
biological_process	GO:0006955	immune response	TAS
biological_process	GO:0007165	signal transduction	TAS
biological_process	GO:0016064	immunoglobulin mediated immune response	IEA
biological_process	GO:0019221	cytokine-mediated signaling pathway	TAS
biological_process	GO:0030728	ovulation	IEA
biological_process	GO:0035771	interleukin-4-mediated signaling pathway	IEA
biological_process	GO:0042127	regulation of cell proliferation	IEA
biological_process	GO:0042832	defense response to protozoan	IEA
biological_process	GO:0043032	positive regulation of macrophage activation	IEA
biological_process	GO:0043306	positive regulation of mast cell degranulation	IEA
biological_process	GO:0043627	response to estrogen	IEA
biological_process	GO:0045626	negative regulation of T-helper 1 cell differentiation	IEA
biological_process	GO:0045630	positive regulation of T-helper 2 cell differentiation	IEA
biological_process	GO:0090197	positive regulation of chemokine secretion	IEA
biological_process	GO:1901741	positive regulation of myoblast fusion	IEA
biological_process	GO:1990834	response to odorant	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005887	integral component of plasma membrane	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0043235	receptor complex	IDA
molecular_function	GO:0004896	cytokine receptor activity	IEA
molecular_function	GO:0004913	interleukin-4 receptor activity	TAS
molecular_function	GO:0005057	obsolete signal transducer activity, downstream of receptor	TAS
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

Interleukin-4 and Interleukin-13 signaling

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000105397	TYK2 / P29597 / tyrosine kinase 2	/ complex / reaction
ENSG00000168610	STAT3 / P40763 / signal transducer and activator of transcription 3	/ complex / reaction
ENSG00000166888	STAT6 / P42226 / signal transducer and activator of transcription 6	/ complex / reaction
ENSG00000147168	IL2RG / P31785 / interleukin 2 receptor subunit gamma	/ complex / reaction
ENSG00000169194	IL13 / P35225 / interleukin 13	/ complex / reaction
ENSG00000171150	SOCS5 / O75159 / suppressor of cytokine signaling 5	/ complex / reaction
ENSG00000162434	JAK1 / P23458 / Janus kinase 1	/ complex
ENSG00000115415	STAT1 / P42224 / signal transducer and activator of transcription 1	/ complex / reaction
ENSG00000131724	P78552 / IL13RA1 / interleukin 13 receptor subunit alpha 1	/ complex / reaction
ENSG00000096968	JAK2 / O60674 / Janus kinase 2	/ complex / reaction
ENSG00000105639	JAK3 / P52333 / Janus kinase 3	/ complex / reaction
ENSG00000113520	IL4 / P05112 / interleukin 4	/ complex / reaction

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr