ENSG00000166888


Homo sapiens

Features
Gene ID: ENSG00000166888
  
Biological name :STAT6
  
Synonyms : P42226 / signal transducer and activator of transcription 6 / STAT6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.3
Gene start: 57095408
Gene end: 57132139
  
Corresponding Affymetrix probe sets: 201331_s_at (Human Genome U133 Plus 2.0 Array)   201332_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452394
Ensembl peptide - ENSP00000452373
Ensembl peptide - ENSP00000491116
Ensembl peptide - ENSP00000300134
Ensembl peptide - ENSP00000401486
Ensembl peptide - ENSP00000438451
Ensembl peptide - ENSP00000444530
Ensembl peptide - ENSP00000445409
Ensembl peptide - ENSP00000450428
Ensembl peptide - ENSP00000450510
Ensembl peptide - ENSP00000450665
Ensembl peptide - ENSP00000450732
Ensembl peptide - ENSP00000450747
Ensembl peptide - ENSP00000450921
Ensembl peptide - ENSP00000451074
Ensembl peptide - ENSP00000451209
Ensembl peptide - ENSP00000451546
Ensembl peptide - ENSP00000451742
Ensembl peptide - ENSP00000451909
Ensembl peptide - ENSP00000452203
NCBI entrez gene - 6778     See in Manteia.
OMIM - 601512
RefSeq - XM_011538709
RefSeq - NM_001178078
RefSeq - NM_001178079
RefSeq - NM_001178080
RefSeq - NM_001178081
RefSeq - NM_003153
RefSeq - XM_006719575
RefSeq - XM_011538703
RefSeq - XM_011538704
RefSeq - XM_011538705
RefSeq - XM_011538706
RefSeq - XM_011538707
RefSeq - XM_011538708
RefSeq Peptide - NP_003144
RefSeq Peptide - NP_001171549
RefSeq Peptide - NP_001171550
RefSeq Peptide - NP_001171551
RefSeq Peptide - NP_001171552
swissprot - H0YIY2
swissprot - H0YJH6
swissprot - G3V2H4
swissprot - G3V2L2
swissprot - G3V2M3
swissprot - G3V2X7
swissprot - G3V370
swissprot - G3V3E9
swissprot - G3V568
swissprot - G3V5I8
swissprot - P42226
swissprot - Q5FBW6
swissprot - A0A1W2PNW1
swissprot - G3V5K5
Ensembl - ENSG00000166888
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stat6ENSDARG00000015902Danio rerio
 Stat6ENSMUSG00000002147Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P42229 / STAT5A / signal transducer and activator of transcription 5AENSG0000012656135
P51692 / STAT5B / signal transducer and activator of transcription 5BENSG0000017375735
STAT1 / P42224 / signal transducer and activator of transcription 1ENSG0000011541522
STAT4 / Q14765 / signal transducer and activator of transcription 4ENSG0000013837821
STAT2 / P52630 / signal transducer and activator of transcription 2ENSG0000017058121
STAT3 / P40763 / signal transducer and activator of transcription 3ENSG0000016861020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil
 IPR028187  STAT6, C-terminal
 IPR035857  STAT6, SH2 domain
 IPR036535  STAT transcription factor, N-terminal domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0002296 T-helper 1 cell lineage commitment IEA
 biological_processGO:0002829 negative regulation of type 2 immune response IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0033598 mammary gland epithelial cell proliferation IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035771 interleukin-4-mediated signaling pathway IMP
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048295 positive regulation of isotype switching to IgE isotypes IEA
 biological_processGO:0060443 mammary gland morphogenesis IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:1902170 cellular response to reactive nitrogen species IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Downstream signal transduction
STAT6-mediated induction of chemokines
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077238 IL4R / P24394 / interleukin 4 receptor  / complex / reaction
 ENSG00000113520 IL4 / P05112 / interleukin 4  / complex / reaction
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex / reaction
 ENSG00000166888 STAT6 / P42226 / signal transducer and activator of transcription 6  / complex / reaction
 ENSG00000147168 IL2RG / P31785 / interleukin 2 receptor subunit gamma  / complex / reaction
 ENSG00000169194 IL13 / P35225 / interleukin 13  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000131724 P78552 / IL13RA1 / interleukin 13 receptor subunit alpha 1  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000105639 JAK3 / P52333 / Janus kinase 3  / complex / reaction
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / complex / reaction
 ENSG00000184584 Q86WV6 / TMEM173 / transmembrane protein 173  / complex / reaction






 

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