ENSG00000134352


Homo sapiens

Features
Gene ID: ENSG00000134352
  
Biological name :IL6ST
  
Synonyms : IL6ST / interleukin 6 signal transducer / P40189
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q11.2
Gene start: 55935095
Gene end: 55994993
  
Corresponding Affymetrix probe sets: 204863_s_at (Human Genome U133 Plus 2.0 Array)   204864_s_at (Human Genome U133 Plus 2.0 Array)   211000_s_at (Human Genome U133 Plus 2.0 Array)   212195_at (Human Genome U133 Plus 2.0 Array)   212196_at (Human Genome U133 Plus 2.0 Array)   234474_x_at (Human Genome U133 Plus 2.0 Array)   234967_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426224
Ensembl peptide - ENSP00000463896
Ensembl peptide - ENSP00000462158
Ensembl peptide - ENSP00000435399
Ensembl peptide - ENSP00000338799
Ensembl peptide - ENSP00000370686
Ensembl peptide - ENSP00000370687
Ensembl peptide - ENSP00000370693
Ensembl peptide - ENSP00000370694
Ensembl peptide - ENSP00000370698
NCBI entrez gene - 3572     See in Manteia.
OMIM - 600694
RefSeq - XM_017009442
RefSeq - XM_017009441
RefSeq - NM_001190981
RefSeq - NM_002184
RefSeq - NM_175767
RefSeq Peptide - NP_002175
RefSeq Peptide - NP_001177910
RefSeq Peptide - NP_786943
swissprot - P40189
swissprot - Q5FC02
swissprot - Q5FC05
swissprot - Q5FC07
swissprot - D6RH03
swissprot - A0A0A0N0L2
Ensembl - ENSG00000134352
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il6stENSDARG00000104693Danio rerio
 IL6STENSGALG00000014716Gallus gallus
 Il6stENSMUSG00000021756Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CSF3R / Q99062 / colony stimulating factor 3 receptorENSG0000011953524
IL31RA / Q8NI17 / interleukin 31 receptor AENSG0000016450921
Q99665 / IL12RB2 / interleukin 12 receptor subunit beta 2ENSG0000008198519
LIFR / P42702 / LIF receptor alphaENSG0000011359417
OSMR / Q99650 / oncostatin M receptorENSG0000014562316


Protein motifs (from Interpro)
Interpro ID Name
 IPR003529  Long hematopoietin receptor, Gp130 family 2, conserved site
 IPR003961  Fibronectin type III
 IPR010457  Immunoglobulin C2-set-like, ligand-binding
 IPR013783  Immunoglobulin-like fold
 IPR015321  Type I cytokine receptor, cytokine-binding domain
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002675 positive regulation of acute inflammatory response IC
 biological_processGO:0002821 positive regulation of adaptive immune response IC
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008593 regulation of Notch signaling pathway IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production TAS
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0034097 response to cytokine IDA
 biological_processGO:0038154 interleukin-11-mediated signaling pathway IEA
 biological_processGO:0038165 oncostatin-M-mediated signaling pathway IMP
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0045669 positive regulation of osteoblast differentiation IMP
 biological_processGO:0048711 positive regulation of astrocyte differentiation IEA
 biological_processGO:0048861 leukemia inhibitory factor signaling pathway IDA
 biological_processGO:0070102 interleukin-6-mediated signaling pathway IMP
 biological_processGO:0070106 interleukin-27-mediated signaling pathway IMP
 biological_processGO:0070120 ciliary neurotrophic factor-mediated signaling pathway IDA
 biological_processGO:0070757 interleukin-35-mediated signaling pathway TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005896 interleukin-6 receptor complex IDA
 cellular_componentGO:0005900 oncostatin-M receptor complex IDA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070110 ciliary neurotrophic factor receptor complex IDA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0004897 ciliary neurotrophic factor receptor activity IDA
 molecular_functionGO:0004915 interleukin-6 receptor activity IDA
 molecular_functionGO:0004921 interleukin-11 receptor activity IEA
 molecular_functionGO:0004923 leukemia inhibitory factor receptor activity IDA
 molecular_functionGO:0004924 oncostatin-M receptor activity IDA
 molecular_functionGO:0005127 ciliary neurotrophic factor receptor binding IPI
 molecular_functionGO:0005138 interleukin-6 receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019838 growth factor binding IPI
 molecular_functionGO:0019970 interleukin-11 binding IEA
 molecular_functionGO:0019981 interleukin-6 binding IPI
 molecular_functionGO:0042803 protein homodimerization activity TAS
 molecular_functionGO:0045509 interleukin-27 receptor activity IC


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
IL-6-type cytokine receptor ligand interactions
Interleukin-35 Signalling
Interleukin-27 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex
 ENSG00000081985 Q99665 / IL12RB2 / interleukin 12 receptor subunit beta 2  / complex
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex / reaction
 ENSG00000095752 IL11 / P20809 / interleukin 11  / complex / reaction
 ENSG00000136244 IL6 / P05231 / interleukin 6  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000160712 IL6R / P08887 / interleukin 6 receptor  / complex / reaction
 ENSG00000099985 OSM / P13725 / oncostatin M  / complex / reaction
 ENSG00000105246 EBI3 / Q14213 / Epstein-Barr virus induced 3  / complex / reaction
 ENSG00000128342 LIF / P15018 / LIF, interleukin 6 family cytokine  / complex / reaction
 ENSG00000113594 LIFR / P42702 / LIF receptor alpha  / complex / reaction
 ENSG00000104998 IL27RA / Q6UWB1 / interleukin 27 receptor subunit alpha  / complex / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000150281 CTF1 / Q16619 / cardiotrophin 1  / complex / reaction
 ENSG00000145623 OSMR / Q99650 / oncostatin M receptor  / complex / reaction
 ENSG00000175505 CLCF1 / Q9UBD9 / cardiotrophin like cytokine factor 1  / complex / reaction
 ENSG00000168811 IL12A / P29459 / interleukin 12A  / complex
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000242689 CNTF / P26441 / ciliary neurotrophic factor  / complex / reaction
 ENSG00000197272 IL27 / Q8NEV9 / interleukin 27  / complex / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex / reaction
 ENSG00000122756 CNTFR / P26992 / ciliary neurotrophic factor receptor  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000006016 CRLF1 / O75462 / cytokine receptor like factor 1  / complex / reaction
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / complex / reaction
 ENSG00000137070 IL11RA / Q14626 / interleukin 11 receptor subunit alpha  / complex / reaction
 ENSG00000138378 STAT4 / Q14765 / signal transducer and activator of transcription 4  / complex






 

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