ENSDARG00000089043


Danio rerio

Features
Gene ID: ENSDARG00000089043
  
Biological name :ptpn6
  
Synonyms : protein tyrosine phosphatase, non-receptor type 6 / ptpn6
  
Possible biological names infered from orthology : P29350 / P29351
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 31720042
Gene end: 31756963
  
Corresponding Affymetrix probe sets: Dr.6437.1.S1_at (Zebrafish Array)   NM_199960_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000146029
Ensembl peptide - ENSDARP00000148161
Ensembl peptide - ENSDARP00000105983
Ensembl peptide - ENSDARP00000125053
NCBI entrez gene - 335573     See in Manteia.
RefSeq - NM_199960
RefSeq - XM_009292429
RefSeq Peptide - NP_956254
swissprot - E7F3D4
swissprot - F8W5L5
ZFIN ID - ZDB-GENE-030131-7513
Ensembl - ENSDARG00000089043
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTPN6ENSGALG00000014561Gallus gallus
 PTPN6ENSG00000111679Homo sapiens
 Ptpn6ENSMUSG00000004266Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ptpn11b / protein tyrosine phosphatase, non-receptor type 11, bENSDARG0000001234056
ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...ENSDARG0000002033454
ptprna / protein tyrosine phosphatase, receptor type, Na / PTPRN* / Q16849* / protein tyrosine phosphatase, receptor type N*ENSDARG0000005864623
ptprn2 / protein tyrosine phosphatase, receptor type, N polypeptide 2 / P80560* / Q92932* / protein tyrosine phosphatase, receptor type N2*ENSDARG0000003597021
ptprnb / protein tyrosine phosphatase, receptor type, Nb / PTPRN* / Q16849* / protein tyrosine phosphatase, receptor type N*ENSDARG0000007704721
ptpn5 / protein tyrosine phosphatase, non-receptor type 5 / P54829* / P54830* / Tyrosine-protein phosphatase non-receptor type 5 *ENSDARG0000007486618
ptprr / protein tyrosine phosphatase, receptor type, r / Q15256* / Q62132*ENSDARG0000010574418


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000980  SH2 domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012152  Protein-tyrosine phosphatase, non-receptor type-6, -11
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0045087 innate immune response IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Costimulation by the CD28 family
Interleukin-3, Interleukin-5 and GM-CSF signaling
Neutrophil degranulation
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain mitotic cell cycle increased process quality , abnormal
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 ZFA:0000088 YSL YSL edematous , abnormal
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 ZFA:0000094 blood island blood island lacks all parts of type leukocyte , abnormal
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 ZFA:0000106 extension extension edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye damaged , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000152 retina retina mitotic cell cycle increased process quality , abnormal
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 ZFA:0000368 integument integument damaged , abnormal
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 ZFA:0001094 whole organism whole organism decreased life span , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0009309 leukocyte leukocyte accumulation heart anatomical region, abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex
 ENSDARG00000089043 ptpn6 / protein tyrosine phosphatase, non-receptor type 6 / P29350* / P29351*  / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000105033 BX897691.1 / BTLA* / Q7Z6A9* / B and T lymphocyte associated*  / complex / reaction






 

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