ENSDARG00000002127


Danio rerio

Features
Gene ID: ENSDARG00000002127
  
Biological name :stam
  
Synonyms : signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / stam
  
Possible biological names infered from orthology : P70297 / Q92783 / signal transducing adaptor molecule
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 31437547
Gene end: 31452606
  
Corresponding Affymetrix probe sets: Dr.16613.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000120829
NCBI entrez gene - 386967     See in Manteia.
RefSeq - XM_005163455
swissprot - A5PMY5
ZFIN ID - ZDB-GENE-031118-123
Ensembl - ENSDARG00000002127
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STAMENSGALG00000035287Gallus gallus
 STAMENSG00000136738Homo sapiens
 StamENSMUSG00000026718Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
stam2 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / O88811* / signal transducing adaptor molecule 2*ENSDARG0000000531851


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002014  VHS domain
 IPR003903  Ubiquitin interacting motif
 IPR008942  ENTH/VHS
 IPR035657  STAM1, SH3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 cellular_componentGO:0005622 intracellular IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Metalloprotease DUBs
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011897 tsg101b / tumor susceptibility 101b / Q99816* / TSG101* / Q61187* / tumor susceptibility 101* / tumor susceptibility gene 101*  / reaction
 ENSDARG00000023600 sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSDARG00000045544 hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSDARG00000039319 vps37b / vacuolar protein sorting 37 homolog B (S. cerevisiae) / Q8R0J7* / Q9H9H4* / VPS37B, ESCRT-I subunit* / vacuolar protein sorting 37B*  / reaction
 ENSDARG00000031836 vps37c / vacuolar protein sorting 37 homolog C (S. cerevisiae) / Q8R105* / A5D8V6* / VPS37C, ESCRT-I subunit* / vacuolar protein sorting 37C*  / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000058746 ubap1 / ubiquitin associated protein 1 / Q8BH48* / Q9NZ09*  / reaction
 ENSDARG00000078216 eps15 / epidermal growth factor receptor pathway substrate 15 / P42566* / P42567* / Epidermal growth factor receptor substrate 15 *  / complex
 ENSDARG00000075853 sh3kbp1 / SH3-domain kinase binding protein 1 / Q8R550* / Q96B97* / SH3 domain containing kinase binding protein 1*  / complex / reaction
 ENSDARG00000020960 hgs / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 *  / complex
 ENSDARG00000097055 si:ch211-284f22.3 / Q86XT2* / Q810I0* / VPS37D* / VPS37D, ESCRT-I subunit* / vacuolar protein sorting 37D*  / reaction
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000103203 vps28 / vacuolar protein sorting 28 (yeast) / Q9D1C8* / Q9UK41* / VPS28, ESCRT-I subunit* / vacuolar protein sorting 28*  / reaction






 

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