ENSDARG00000019231


Danio rerio

Features
Gene ID: ENSDARG00000019231
  
Biological name :sptan1
  
Synonyms : spectrin alpha, non-erythrocytic 1 / sptan1
  
Possible biological names infered from orthology : P02549 / P08032 / P16546 / Q13813 / Spectrin alpha chain, erythrocytic 1 / Spectrin alpha chain, non-erythrocytic 1 / spectrin alpha, erythrocytic 1 / SPTA1
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 13150937
Gene end: 13217905
  
Corresponding Affymetrix probe sets: Dr.1940.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000093027
Ensembl peptide - ENSDARP00000093029
Ensembl peptide - ENSDARP00000123572
NCBI entrez gene - 553383     See in Manteia.
RefSeq - NM_001098488
RefSeq - XM_021468830
RefSeq - XM_021468831
RefSeq Peptide - NP_001091958
swissprot - F1R446
swissprot - F1QDX2
swissprot - F1R445
ZFIN ID - ZDB-GENE-051113-60
Ensembl - ENSDARG00000019231
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPTAN1ENSGALG00000004719Gallus gallus
 Q13813ENSG00000197694Homo sapiens
 SPTA1ENSG00000163554Homo sapiens
 P16546ENSMUSG00000057738Mus musculus
 Spta1ENSMUSG00000026532Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sptb / spectrin, beta, erythrocytic / P11277*ENSDARG0000003049021
sptbn2 / spectrin, beta, non-erythrocytic 2 / O15020*ENSDARG0000005395621
sptbn1 / spectrin, beta, non-erythrocytic 1 / Q01082* / Q62261* / Spectrin beta chain, non-erythrocytic 1 *ENSDARG0000010288321
sptbn5 / spectrin, beta, non-erythrocytic 5 / Q9NRC6*ENSDARG0000009768320
SPTBN4 / si:ch73-262h23.4 / Q9H254* / spectrin beta, non-erythrocytic 4*ENSDARG0000009262411
actn1 / actinin, alpha 1 / P12814* / Q7TPR4* / Mus musculus actinin, alpha 1 (Actn1), transcript variant 2, mRNA.*ENSDARG000000072197
actn2b / actinin, alpha 2b / ACTN2* / P35609* / Q9JI91* / actinin alpha 2* / Alpha-actinin-2 *ENSDARG000000710907
actn4 / actinin, alpha 4 / O43707*ENSDARG000000997867
actn3b / actinin alpha 3b / ACTN3* / Q08043* / O88990* / Alpha-actinin-3 * / actinin alpha 3 (gene/pseudogene)*ENSDARG000000014316
actn3a / actinin alpha 3a / ACTN3* / Q08043* / O88990* / Alpha-actinin-3 * / actinin alpha 3 (gene/pseudogene)*ENSDARG000000137556
si:dkey-27p18.5 / Q9H254* / SPTBN4* / spectrin beta, non-erythrocytic 4*ENSDARG000000686246
si:ch73-262h23.4 / Q9H254* / SPTBN4* / spectrin beta, non-erythrocytic 4*ENSDARG000001119424
si:zfos-1837d3.1 / Q62261* / Q01082* / SPTBN1* / spectrin beta, non-erythrocytic 1* / Spectrin beta chain, non-erythrocytic 1 *ENSDARG000001054281


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002017  Spectrin repeat
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR014837  EF-hand, Ca insensitive
 IPR018159  Spectrin/alpha-actinin
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045162 clustering of voltage-gated sodium channels IMP
 cellular_componentGO:0033268 node of Ranvier IDA
 cellular_componentGO:0033270 paranode region of axon IDA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Caspase-mediated cleavage of cytoskeletal proteins
NCAM signaling for neurite out-growth
Interaction between L1 and Ankyrins
RAF/MAP kinase cascade
Neutrophil degranulation
COPI-mediated anterograde transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord voltage-gated sodium channel complex decreased amount , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000123 liver liver necrotic , abnormal
Show

 ZFA:0000175 posterior lateral line nerve posterior lateral line nerve voltage-gated sodium channel complex decreased amount , abnormal
posterior lateral line nerve node of Ranvier increased length , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000001769 ptpra / protein tyrosine phosphatase, receptor type, A / P18052* / P18433*  / complex
 ENSDARG00000037746 actb1 / Q7ZVI7 / actin, beta 1 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / complex
 ENSDARG00000037870 actb2 / Q7ZVF9 / actin, beta 2 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000019231 sptan1 / spectrin alpha, non-erythrocytic 1 / SPTA1* / Q13813* / P08032* / P16546* / P02549* / spectrin alpha, erythrocytic 1* / Spectrin alpha chain, erythrocytic 1 * / Spectrin alpha chai...  / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex






 

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