ENSDARG00000071090


Danio rerio

Features
Gene ID: ENSDARG00000071090
  
Biological name :actn2b
  
Synonyms : actinin, alpha 2b / actn2b
  
Possible biological names infered from orthology : actinin alpha 2 / ACTN2 / Alpha-actinin-2 / P35609 / Q9JI91
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 20122019
Gene end: 20143946
  
Corresponding Affymetrix probe sets: Dr.22219.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000115698
Ensembl peptide - ENSDARP00000116081
NCBI entrez gene - 641575     See in Manteia.
RefSeq - NM_001037573
RefSeq Peptide - NP_001032662
swissprot - E9QFR8
swissprot - E9QCQ2
ZFIN ID - ZDB-GENE-051127-39
Ensembl - ENSDARG00000071090
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACTN2ENSGALG00000014463Gallus gallus
 ACTN2ENSG00000077522Homo sapiens
 Actn2ENSMUSG00000052374Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
actn3b / actinin alpha 3b / ACTN3* / Q08043* / O88990* / Alpha-actinin-3 * / actinin alpha 3 (gene/pseudogene)*ENSDARG0000000143182
actn3a / actinin alpha 3a / ACTN3* / Q08043* / O88990* / Alpha-actinin-3 * / actinin alpha 3 (gene/pseudogene)*ENSDARG0000001375582
actn1 / actinin, alpha 1 / P12814* / Q7TPR4* / Mus musculus actinin, alpha 1 (Actn1), transcript variant 2, mRNA.*ENSDARG0000000721978
actn4 / actinin, alpha 4 / O43707*ENSDARG0000009978678
sptbn5 / spectrin, beta, non-erythrocytic 5 / Q9NRC6*ENSDARG0000009768331
sptbn2 / spectrin, beta, non-erythrocytic 2 / O15020*ENSDARG0000005395629
sptb / spectrin, beta, erythrocytic / P11277*ENSDARG0000003049028
sptbn1 / spectrin, beta, non-erythrocytic 1 / Q01082* / Q62261* / Spectrin beta chain, non-erythrocytic 1 *ENSDARG0000010288328
SPTBN4 / si:ch73-262h23.4 / Q9H254* / spectrin beta, non-erythrocytic 4*ENSDARG0000009262423
sptan1 / spectrin alpha, non-erythrocytic 1 / SPTA1* / Q13813* / P08032* / P16546* / P02549* / spectrin alpha, erythrocytic 1* / Spectrin alpha chain, erythrocytic 1 * / Spectrin alpha chai...ENSDARG0000001923119
si:dkey-27p18.5 / Q9H254* / SPTBN4* / spectrin beta, non-erythrocytic 4*ENSDARG000000686244
si:zfos-1837d3.1 / Q62261* / Q01082* / SPTBN1* / spectrin beta, non-erythrocytic 1* / Spectrin beta chain, non-erythrocytic 1 *ENSDARG000001054282
si:ch73-262h23.4 / Q9H254* / SPTBN4* / spectrin beta, non-erythrocytic 4*ENSDARG000001119421


Protein motifs (from Interpro)
Interpro ID Name
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR002017  Spectrin repeat
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR014837  EF-hand, Ca insensitive
 IPR018159  Spectrin/alpha-actinin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0048741 skeletal muscle fiber development IMP
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Striated Muscle Contraction
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle increased size , abnormal
Show

 ZFA:0000035 lens lens cell nucleate quality , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye lacks all parts of type retinal photoreceptor layer , abnormal
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 ZFA:0000114 heart heart increased size , abnormal
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 ZFA:0000471 atrium atrium increased size , abnormal
atrium lacks parts or has fewer parts of type cardiac muscle cell sarcomere, abnormal
atrium lacks parts or has fewer parts of type cardiac muscle cell Z disc, abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
whole organism refractivity , abnormal
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 ZFA:0005061 ventricular myocardium ventricular myocardium decreased size , abnormal
ventricular myocardium decreased volume , abnormal
ventricular myocardium cardiac chamber ballooning decreased occurrence , abnormal
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 ZFA:0005277 skeletal muscle skeletal muscle morphology , abnormal
skeletal muscle lacks parts or has fewer parts of type slow muscle cell myofibril, abnormal
skeletal muscle myofibril morphology , abnormal
skeletal muscle contractile fiber decreased size , abnormal
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 ZFA:0005280 cardiac muscle cardiac muscle myofibril disorganized , abnormal
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 ZFA:0009116 slow muscle cell slow muscle cell decreased diameter , abnormal
slow muscle cell decreased amount , abnormal
slow muscle cell nucleus circular , abnormal
slow muscle cell myofibril disorganized , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased amount , abnormal
cardiac muscle cell sarcomere disorganized , abnormal
cardiac muscle cell Z disc shape , abnormal
cardiac muscle cell Z disc decreased length , abnormal
cardiac muscle cell Z disc increased width , abnormal
cardiac muscle cell Z disc decreased size , abnormal
cardiac muscle cell shape , abnormal
cardiac muscle cell decreased size , abnormal
cardiac muscle cell Z disc broken , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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