ENSDARG00000018817


Danio rerio

Features
Gene ID: ENSDARG00000018817
  
Biological name :bdnf
  
Synonyms : bdnf / brain-derived neurotrophic factor
  
Possible biological names infered from orthology : P21237 / P23560
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 31924983
Gene end: 31941670
  
Corresponding Affymetrix probe sets: Dr.8195.1.A1_at (Zebrafish Array)   NM_131595_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000114671
Ensembl peptide - ENSDARP00000152925
Ensembl peptide - ENSDARP00000120771
Ensembl peptide - ENSDARP00000010990
Ensembl peptide - ENSDARP00000069872
Ensembl peptide - ENSDARP00000108984
NCBI entrez gene - 58118     See in Manteia.
RefSeq - NM_131595
RefSeq - NM_001308649
RefSeq Peptide - NP_001295578
RefSeq Peptide - NP_571670
swissprot - E9QIT5
swissprot - B0V301
swissprot - F1Q5K0
swissprot - Q6NZ01
ZFIN ID - ZDB-GENE-000412-1
Ensembl - ENSDARG00000018817
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BDNFENSGALG00000012163Gallus gallus
 BDNFENSG00000176697Homo sapiens
 BdnfENSMUSG00000048482Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ntf3 / neurotrophin 3 / P20181* / P20783*ENSDARG0000005904328
ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *ENSDARG0000005896125
ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *ENSDARG0000001405024


Protein motifs (from Interpro)
Interpro ID Name
 IPR002072  Nerve growth factor-related
 IPR019846  Nerve growth factor conserved site
 IPR020408  Nerve growth factor-like
 IPR020430  Brain-derived neurotrophic factor
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007420 brain development IEP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0033555 multicellular organismal response to stress IEP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IBA
 biological_processGO:0045664 regulation of neuron differentiation IBA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 biological_processGO:0071542 dopaminergic neuron differentiation IMP
 biological_processGO:0099054 presynapse assembly IGI
 cellular_componentGO:0005576 extracellular region IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005169 neurotrophin TRKB receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IBA


Pathways (from Reactome)
Pathway description
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through FRS2 and FRS3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium swollen , abnormal
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 ZFA:0000076 swim bladder swim bladder aplastic , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000435 cranial nerve II cranial nerve II aplastic , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001261 ventricular system ventricular system increased size , abnormal
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 ZFA:0001273 ventral mandibular arch ventral mandibular arch malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018817 bdnf / brain-derived neurotrophic factor / P21237* / P23560*  / complex
 ENSDARG00000059897 ntrk2a / neurotrophic tyrosine kinase, receptor, type 2a / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*  / complex
 ENSDARG00000098511 ntrk2b / neurotrophic tyrosine kinase, receptor, type 2b / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*  / complex
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex






 

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