ENSDARG00000028663


Danio rerio

Features
Gene ID: ENSDARG00000028663
  
Biological name :tek
  
Synonyms : tek / TEK tyrosine kinase, endothelial
  
Possible biological names infered from orthology : Q02763 / Q02858 / TEK receptor tyrosine kinase
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 480119
Gene end: 496781
  
Corresponding Affymetrix probe sets: Dr.593.1.S1_at (Zebrafish Array)   NM_131461_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000055680
Ensembl peptide - ENSDARP00000124633
NCBI entrez gene - 30747     See in Manteia.
RefSeq - NM_131461
RefSeq Peptide - NP_571536
swissprot - F8W2R6
swissprot - B3DJR6
ZFIN ID - ZDB-GENE-990415-56
Ensembl - ENSDARG00000028663
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TEKENSGALG00000001840Gallus gallus
 TEKENSG00000120156Homo sapiens
 TekENSMUSG00000006386Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tie1 / tyrosine kinase with immunoglobulin-like and EGF-like domains 1 / P35590* / Q06806*ENSDARG0000000410542
tyro3 / TYRO3 protein tyrosine kinase / P55144* / Q06418* / TYRO3 protein tyrosine kinase 3*ENSDARG0000000535616
mertka / c-mer proto-oncogene tyrosine kinase a / MERTK* / Q12866* / Q60805* / Tyrosine-protein kinase Mer * / MER proto-oncogene, tyrosine kinase*ENSDARG0000007469516
mst1rb / macrophage stimulating 1 receptor b / MST1R* / Q04912* / Q62190* / macrophage stimulating 1 receptor* / macrophage stimulating 1 receptor (c-met-related tyrosine kinase)*ENSDARG0000000487115
met / MET proto-oncogene, receptor tyrosine kinase / P08581*ENSDARG0000007090315
mst1ra / macrophage stimulating 1 receptor a / MST1R* / Q04912* / Q62190* / macrophage stimulating 1 receptor* / macrophage stimulating 1 receptor (c-met-related tyrosine kinase)*ENSDARG0000006023514
si:ch73-40a2.1ENSDARG0000010552113
AXL / AXL receptor tyrosine kinase / P30530*ENSDARG0000011204513
ryk / receptor-like tyrosine kinase / Q01887* / Tyrosine-protein kinase RYK *ENSDARG0000000723111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000742  EGF-like domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR018941  Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Tie2 Signaling
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000114 heart heart anatomical compartment boundary detached from heart , abnormal
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 ZFA:0000180 caudal vein caudal vein morphology , abnormal
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 ZFA:0000186 common cardinal vein common cardinal vein morphology , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel truncated , abnormal
intersegmental vessel aplastic , abnormal
intersegmental vessel decreased amount , abnormal
intersegmental vessel morphology , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel broken , abnormal
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 ZFA:0005034 parachordal vessel parachordal vessel aplastic , abnormal
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 ZFA:0005035 subintestinal vein subintestinal vein morphology , abnormal
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 ZFA:0005297 cranial blood vessel cranial blood vessel decreased permeability , abnormal
cranial blood vessel hemorrhagic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000028663 tek / TEK tyrosine kinase, endothelial / Q02763* / TEK receptor tyrosine kinase*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000068280 GRB14 / growth factor receptor bound protein 14 / Q14449*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSDARG00000018060 pik3r2 / phosphoinositide-3-kinase, regulatory subunit 2 (beta) / O00459* / O08908* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulator...  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000076787 angpt4 / angiopoietin 4 / Q9Y264*  / complex / reaction






 

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