ENSDARG00000004105


Danio rerio

Features
Gene ID: ENSDARG00000004105
  
Biological name :tie1
  
Synonyms : tie1 / tyrosine kinase with immunoglobulin-like and EGF-like domains 1
  
Possible biological names infered from orthology : P35590 / Q06806
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 33979523
Gene end: 34008901
  
Corresponding Affymetrix probe sets: Dr.12289.1.S1_at (Zebrafish Array)   Dr.594.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000154055
Ensembl peptide - ENSDARP00000016803
Ensembl peptide - ENSDARP00000145497
Ensembl peptide - ENSDARP00000147239
Ensembl peptide - ENSDARP00000151239
NCBI entrez gene - 30746     See in Manteia.
RefSeq - NM_001346150
RefSeq Peptide - NP_001333079
swissprot - G1K2H0
ZFIN ID - ZDB-GENE-990415-55
Ensembl - ENSDARG00000004105
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TIE1ENSGALG00000009957Gallus gallus
 TIE1ENSG00000066056Homo sapiens
 Tie1ENSMUSG00000033191Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tek / TEK tyrosine kinase, endothelial / Q02763* / TEK receptor tyrosine kinase*ENSDARG0000002866340
tyro3 / TYRO3 protein tyrosine kinase / P55144* / Q06418* / TYRO3 protein tyrosine kinase 3*ENSDARG0000000535616
met / MET proto-oncogene, receptor tyrosine kinase / P08581*ENSDARG0000007090315
mertka / c-mer proto-oncogene tyrosine kinase a / MERTK* / Q12866* / Q60805* / Tyrosine-protein kinase Mer * / MER proto-oncogene, tyrosine kinase*ENSDARG0000007469515
mst1rb / macrophage stimulating 1 receptor b / MST1R* / Q04912* / Q62190* / macrophage stimulating 1 receptor* / macrophage stimulating 1 receptor (c-met-related tyrosine kinase)*ENSDARG0000000487114
mst1ra / macrophage stimulating 1 receptor a / MST1R* / Q04912* / Q62190* / macrophage stimulating 1 receptor* / macrophage stimulating 1 receptor (c-met-related tyrosine kinase)*ENSDARG0000006023514
AXL / AXL receptor tyrosine kinase / P30530*ENSDARG0000011204514
si:ch73-40a2.1ENSDARG0000010552113
ryk / receptor-like tyrosine kinase / Q01887* / Tyrosine-protein kinase RYK *ENSDARG0000000723111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000742  EGF-like domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001057 intersegmental vein intersegmental vein truncated , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel hypoplastic , abnormal
intersegmental vessel malformed , abnormal
Show

 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel aplastic/hypoplastic , abnormal
Show

 ZFA:0005257 blood vessel endothelium blood vessel endothelium cell-cell junction mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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