ENSDARG00000038010


Danio rerio

Features
Gene ID: ENSDARG00000038010
  
Biological name :rac2
  
Synonyms : rac2 / Rac family small GTPase 2
  
Possible biological names infered from orthology : P15153 / Q05144 / Ras-related C3 botulinum toxin substrate 2
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 29510818
Gene end: 29544039
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000106947
Ensembl peptide - ENSDARP00000055406
Ensembl peptide - ENSDARP00000148386
NCBI entrez gene - 415151     See in Manteia.
swissprot - A2BHI1
swissprot - Q6IQN5
ZFIN ID - ZDB-GENE-040625-27
Ensembl - ENSDARG00000038010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAC2ENSGALG00000012456Gallus gallus
 RAC2ENSG00000128340Homo sapiens
 Rac2ENSMUSG00000033220Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rac1a / Rac family small GTPase 1a / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000007484980
rac1b / Rac family small GTPase 1b / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000008795480
rac3b / Rac family small GTPase 3b / RAC3* / P60764* / P60763* / Rac family small GTPase 3* / RAS-related C3 botulinum substrate 3*ENSDARG0000002079579
rac3a / Rac family small GTPase 3a / RAC3* / P60763* / Rac family small GTPase 3*ENSDARG0000009006279
si:ch211-1f22.1 / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000001320360
rhogd / ras homolog gene family, member GdENSDARG0000003060860
rhogb / ras homolog family member Gb / RHOG* / P84095* / P84096* / ras homolog family member G*ENSDARG0000000430159
rhogc / ras homolog gene family, member GcENSDARG0000002840159
cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *ENSDARG0000004457359
cdc42l / cell division cycle 42, likeENSDARG0000004015858
rac1l / Rac family small GTPase 1, like / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000005464958
rhoga / ras homolog family member Ga / RHOG* / P84095* / P84096* / ras homolog family member G*ENSDARG0000006865358
rhoq / ras homolog family member Q / P17081* / Q8R527* / Rho-related GTP-binding protein RhoQ *ENSDARG0000002595355
rhoj / ras homolog family member J / Q9ER71* / Q9H4E5*ENSDARG0000002025053
si:ch211-1f22.2 / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000009666653
rac1l / si:ch73-94k4.2 / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000009654951
cdc42l2 / cell division cycle 42 like 2ENSDARG0000005786948
rhoua / ras homolog family member Ua / RHOU* / Q9EQT3* / Q7L0Q8* / ras homolog family member U* / Rho-related GTP-binding protein RhoU *ENSDARG0000001970947
rhoub / ras homolog family member UbENSDARG0000001296844
RHOU (1 of many) / si:ch211-133l11.10 / RHOU* / Q9EQT3* / Q7L0Q8* / ras homolog family member U* / Rho-related GTP-binding protein RhoU *ENSDARG0000000562643


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001780 neutrophil homeostasis IMP
 biological_processGO:0002446 neutrophil mediated immunity IMP
 biological_processGO:0002685 regulation of leukocyte migration IMP
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0032878 regulation of establishment or maintenance of cell polarity IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0048246 macrophage chemotaxis IMP
 biological_processGO:0050832 defense response to fungus IMP
 biological_processGO:1905517 macrophage migration IMP
 biological_processGO:1990266 neutrophil migration IMP
 biological_processGO:2000391 positive regulation of neutrophil extravasation IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
PCP/CE pathway
G alpha (12/13) signalling events
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000051 otic vesicle otic vesicle neutrophil decreased amount , abnormal
otic vesicle macrophage decreased amount , abnormal
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 ZFA:0000054 pericardium pericardium neutrophil increased amount , abnormal
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 ZFA:0000108 fin fin broken , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism decreased size , abnormal
whole organism decreased life span , abnormal
whole organism decreased life span , ameliorated
whole organism decreased life span , exacerbated
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 ZFA:0001114 head head neutrophil decreased amount , abnormal
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 ZFA:0001115 trunk trunk neutrophil decreased amount , abnormal
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 ZFA:0009043 circulating cell circulating cell neutrophil increased amount , abnormal
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 ZFA:0009141 macrophage macrophage decreased velocity , abnormal
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 ZFA:0009327 neutrophil neutrophil spatial pattern , abnormal
neutrophil decreased amount , abnormal
neutrophil decreased velocity , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018283 cyba / cytochrome b-245, alpha polypeptide / P13498* / cytochrome b-245 alpha chain*  / complex / reaction
 ENSDARG00000040812 ncf4 / neutrophil cytosolic factor 4 / P97369* / Q15080* / Neutrophil cytosol factor 4 *  / complex / reaction
 ENSDARG00000056615 cybb / cytochrome b-245, beta polypeptide (chronic granulomatous disease) / Q61093* / P04839* / cytochrome b-245 beta chain* / Cytochrome b-245 heavy chain *  / complex / reaction
 ENSDARG00000005821 ncf2 / neutrophil cytosolic factor 2 / O70145* / P19878* / Neutrophil cytosol factor 2 *  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000073765 gna13a / guanine nucleotide binding protein (G protein), alpha 13a / GNA13* / Q14344* / P27601* / G protein subunit alpha 13* / guanine nucleotide binding protein, alpha 13*  / reaction
 ENSDARG00000055837 arhgef1b / Rho guanine nucleotide exchange factor (GEF) 1b / Q61210* / Q92888* / ARHGEF1* / Rho guanine nucleotide exchange factor 1*  / reaction






 

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