ENSDARG00000056615


Danio rerio

Features
Gene ID: ENSDARG00000056615
  
Biological name :cybb
  
Synonyms : cybb / cytochrome b-245, beta polypeptide (chronic granulomatous disease)
  
Possible biological names infered from orthology : cytochrome b-245 beta chain / Cytochrome b-245 heavy chain / P04839 / Q61093
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 29795155
Gene end: 29818866
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000073592
Ensembl peptide - ENSDARP00000143691
NCBI entrez gene - 393386     See in Manteia.
RefSeq - NM_200414
RefSeq Peptide - NP_956708
swissprot - F1QV52
swissprot - A0A286Y943
ZFIN ID - ZDB-GENE-040426-1380
Ensembl - ENSDARG00000056615
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYBBENSGALG00000016261Gallus gallus
 CYBBENSG00000165168Homo sapiens
 CybbENSMUSG00000015340Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nox1 / NADPH oxidase 1 / Q8CIZ9* / Q9Y5S8*ENSDARG0000008757460
duox / dual oxidase / DUOX1* / DUOX2* / Q9NRD9* / Q9NRD8* / dual oxidase 1* / dual oxidase 2*ENSDARG0000006263228
nox5 / NADPH oxidase, EF-hand calcium binding domain 5 / Q96PH1* / NADPH oxidase 5*ENSDARG0000007977328
NOX4 / NADPH oxidase 4 / Q9NPH5*ENSDARG0000011493715


Protein motifs (from Interpro)
Interpro ID Name
 IPR000778  Cytochrome b245, heavy chain
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism reactive oxygen species decreased amount , abnormal
Show

 ZFA:0009327 neutrophil neutrophil increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018283 cyba / cytochrome b-245, alpha polypeptide / P13498* / cytochrome b-245 alpha chain*  / complex
 ENSDARG00000038010 rac2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *  / complex / reaction
 ENSDARG00000040812 ncf4 / neutrophil cytosolic factor 4 / P97369* / Q15080* / Neutrophil cytosol factor 4 *  / complex
 ENSDARG00000005821 ncf2 / neutrophil cytosolic factor 2 / O70145* / P19878* / Neutrophil cytosol factor 2 *  / complex






 

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