ENSDARG00000079773


Danio rerio

Features
Gene ID: ENSDARG00000079773
  
Biological name :nox5
  
Synonyms : NADPH oxidase, EF-hand calcium binding domain 5 / nox5
  
Possible biological names infered from orthology : NADPH oxidase 5 / Q96PH1
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 7927349
Gene end: 7946732
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000101214
Ensembl peptide - ENSDARP00000149762
swissprot - E7F9M1
ZFIN ID - ZDB-GENE-091120-9
Ensembl - ENSDARG00000079773
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOX5ENSGALG00000008063Gallus gallus
 NOX5ENSG00000255346Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
duox / dual oxidase / DUOX1* / DUOX2* / Q9NRD9* / Q9NRD8* / dual oxidase 1* / dual oxidase 2*ENSDARG0000006263225
cybb / cytochrome b-245, beta polypeptide (chronic granulomatous disease) / Q61093* / P04839* / cytochrome b-245 beta chain* / Cytochrome b-245 heavy chain *ENSDARG0000005661522
nox1 / NADPH oxidase 1 / Q8CIZ9* / Q9Y5S8*ENSDARG0000008757422
NOX4 / NADPH oxidase 4 / Q9NPH5*ENSDARG0000011493710


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR018247  EF-Hand 1, calcium-binding site
 IPR029648  NADPH oxidase 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042554 superoxide anion generation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1990266 neutrophil migration IGI
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009327 neutrophil neutrophil decreased velocity , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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