ENSDARG00000060010


Danio rerio

Features
Gene ID: ENSDARG00000060010
  
Biological name :iqgap2
  
Synonyms : iqgap2 / IQ motif containing GTPase activating protein 2
  
Possible biological names infered from orthology : Q13576 / Q3UQ44 / Ras GTPase-activating-like protein IQGAP2
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 46077710
Gene end: 46196708
  
Corresponding Affymetrix probe sets: Dr.7282.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000078504
Ensembl peptide - ENSDARP00000122218
NCBI entrez gene - 563030     See in Manteia.
RefSeq - NM_001128340
RefSeq Peptide - NP_001121812
swissprot - F1QAC1
swissprot - A2CE93
ZFIN ID - ZDB-GENE-030131-2878
Ensembl - ENSDARG00000060010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IQGAP2ENSGALG00000014978Gallus gallus
 IQGAP2ENSG00000145703Homo sapiens
 Iqgap2ENSMUSG00000021676Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
iqgap1 / IQ motif containing GTPase activating protein 1 / P46940*ENSDARG0000007888859
iqgap3 / IQ motif containing GTPase activating protein 3 / Q86VI3*ENSDARG0000009865051


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000593  RasGAP protein, C-terminal
 IPR001202  WW domain
 IPR001715  Calponin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003094 glomerular filtration IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0072015 glomerular visceral epithelial cell development IMP


Pathways (from Reactome)
Pathway description
RHO GTPases activate IQGAPs
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus increased size , abnormal
Show

 ZFA:0001558 pronephric tubule pronephric tubule dilated , abnormal
Show

 ZFA:0005283 renal capsular space renal capsular space increased size , abnormal
Show

 ZFA:0005285 glomerular basement membrane glomerular basement membrane podocyte foot morphology , abnormal
glomerular basement membrane podocyte foot increased width , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000037746 actb1 / Q7ZVI7 / actin, beta 1 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / complex / reaction
 ENSDARG00000060010 iqgap2 / IQ motif containing GTPase activating protein 2 / Q13576* / Q3UQ44* / Ras GTPase-activating-like protein IQGAP2 *  / complex
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex / reaction
 ENSDARG00000037870 actb2 / Q7ZVF9 / actin, beta 2 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / complex / reaction
 ENSDARG00000100825 calm2a / calm2b / calm3a / Q6PI52 / calmodulin 2a (phosphorylase kinase, delta)  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr