ENSDARG00000100940


Danio rerio

Features
Gene ID: ENSDARG00000100940
  
Biological name :nr5a2
  
Synonyms : nr5a2 / nuclear receptor subfamily 5, group A, member 2
  
Possible biological names infered from orthology : O00482 / P45448
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 22634007
Gene end: 22719440
  
Corresponding Affymetrix probe sets: Dr.6870.1.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000141532
NCBI entrez gene - 30749     See in Manteia.
RefSeq - NM_001313729
RefSeq Peptide - NP_001300658
swissprot - A0A0R4IW70
swissprot - Q90YL6
ZFIN ID - ZDB-GENE-990415-79
Ensembl - ENSDARG00000100940
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NR5A2ENSGALG00000002182Gallus gallus
 NR5A2ENSG00000116833Homo sapiens
 Nr5a2ENSMUSG00000026398Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nr5a1b / nuclear receptor subfamily 5, group A, member 1b / NR5A1* / P33242* / Q13285* / Steroidogenic factor 1 * / nuclear receptor subfamily 5 group A member 1*ENSDARG0000002336261
nr5a1a / nuclear receptor subfamily 5, group A, member 1a / NR5A1* / P33242* / Q13285* / Steroidogenic factor 1 * / nuclear receptor subfamily 5 group A member 1*ENSDARG0000010317654
nr5a5 / nuclear receptor subfamily 5, group A, member 5ENSDARG0000003911649
nr1d2a / nuclear receptor subfamily 1, group D, member 2aENSDARG0000000382021
nr1d2b / nuclear receptor subfamily 1, group D, member 2b / NR1D2* / Q60674* / Q14995* / nuclear receptor subfamily 1 group D member 2*ENSDARG0000000959421
nr1d4a / nuclear receptor subfamily 1, group D, member 4aENSDARG0000003116121
nr1d1 / nuclear receptor subfamily 1, group d, member 1 / P20393* / Q3UV55*ENSDARG0000003316021
nr1d4b / nuclear receptor subfamily 1, group D, member 4bENSDARG0000005937021
rorcb / RAR-related orphan receptor C bENSDARG0000001778020
roraa / RAR-related orphan receptor A, paralog a / RORA* / P51448* / P35398* / RAR related orphan receptor A* / RAR-related orphan receptor alpha*ENSDARG0000003176820
rorab / RAR-related orphan receptor A, paralog bENSDARG0000000191019
rorb / RAR-related orphan receptor B / Q8R1B8* / Q92753* / Nuclear receptor ROR-beta *ENSDARG0000003349819
rorca / RAR-related orphan receptor C aENSDARG0000005723119
nr6a1a / nuclear receptor subfamily 6, group A, member 1a / NR6A1* / Q64249* / Q15406* / nuclear receptor subfamily 6 group A member 1*ENSDARG0000010150819
pparaa / peroxisome proliferator-activated receptor alpha a / PPARA* / P23204* / Q07869* / peroxisome proliferator activated receptor alpha*ENSDARG0000003177718
pparab / peroxisome proliferator-activated receptor alpha b / PPARA* / P23204* / Q07869* / peroxisome proliferator activated receptor alpha*ENSDARG0000005432318
nr6a1b / nuclear receptor subfamily 6, group A, member 1bENSDARG0000001448017
ppardb / peroxisome proliferator-activated receptor delta b / PPARD* / P35396* / Q03181* / peroxisome proliferator activated receptor delta*ENSDARG0000000947316
pparda / peroxisome proliferator-activated receptor delta a / PPARD* / P35396* / Q03181* / peroxisome proliferator activated receptor delta*ENSDARG0000004452516
rorc / RAR-related orphan receptor C / P51449* / P51450* / Nuclear receptor ROR-gamma *ENSDARG0000008719510


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR016355  Nuclear hormone receptor family 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IBA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0031017 exocrine pancreas development IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0061017 hepatoblast differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IBA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IBA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000123 liver liver decreased distribution , abnormal
liver decreased size , abnormal
liver decreased amount , abnormal
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 ZFA:0000140 pancreas pancreas decreased size , abnormal
pancreas decreased amount , abnormal
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 ZFA:0000339 digestive system digestive system G1/S transition of mitotic cell cycle delayed , abnormal
digestive system cell proliferation disrupted , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
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 ZFA:0001249 exocrine pancreas exocrine pancreas decreased size , abnormal
exocrine pancreas decreased distribution , abnormal
exocrine pancreas absent , abnormal
exocrine pancreas cell decreased amount , abnormal
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 ZFA:0001338 intestine intestine decreased size , abnormal
intestine decreased amount , abnormal
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 ZFA:0001390 pancreatic bud pancreatic bud decreased distribution , abnormal
pancreatic bud decreased size , abnormal
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 ZFA:0001458 cranial cartilage cranial cartilage decreased amount , abnormal
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 ZFA:0009277 acinar cell acinar cell absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / reaction / complex
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000077404 ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / complex
 ENSDARG00000088123 znf217 / zinc finger protein 217 / O75362*  / complex
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex
 ENSDARG00000068436 Q6PI20 / h3f3b.1 / H3 histone, family 3B.1 / H3F3B* / H3F3C* / P84243* / Q6NXT2* / H3 histone family member 3C* / H3 histone family member 3B*  / complex
 ENSDARG00000105345 zgc:173552  / complex
 ENSDARG00000105359 Q4QRF4 / FP325123.1 / Histone H3.2   / complex






 

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