ENSDARG00000010487


Danio rerio

Features
Gene ID: ENSDARG00000010487
  
Biological name :sae1
  
Synonyms : Q6IQS6 / sae1 / SUMO1 activating enzyme subunit 1
  
Possible biological names infered from orthology : Q9R1T2 / Q9UBE0 / SUMO-activating enzyme subunit 1 SUMO-activating enzyme subunit 1, N-terminally processed
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 23722620
Gene end: 23739104
  
Corresponding Affymetrix probe sets: Dr.804.1.S1_at (Zebrafish Array)   NM_001002058_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000016138
NCBI entrez gene - 415148     See in Manteia.
RefSeq - NM_001002058
RefSeq Peptide - NP_001002058
swissprot - Q6IQS6
ZFIN ID - ZDB-GENE-040625-21
Ensembl - ENSDARG00000010487
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SAE1ENSG00000142230Homo sapiens
 Sae1ENSMUSG00000052833Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000011  Ubiquitin/SUMO-activating enzyme E1
 IPR000594  THIF-type NAD/FAD binding fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0016925 protein sumoylation IMP
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0061484 hematopoietic stem cell homeostasis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031510 SUMO activating enzyme complex ISS
 molecular_functionGO:0008022 protein C-terminus binding ISS
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0019948 SUMO activating enzyme activity IBA


Pathways (from Reactome)
Pathway description
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000094 blood island blood island hematopoietic stem cell decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased size , abnormal
whole organism decreased behavioural activity , abnormal
whole organism dead , abnormal
Show

 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000101332 uba2 / Q7SXG4 / ubiquitin-like modifier activating enzyme 2 / Q9UBT2* / Q9Z1F9*  / complex






 

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