ENSDARG00000025032
Danio rerio receptor nr3c1 hormone glucocorticoid transcription ion binding nuclear regulation response pathway steroid zinc dna-templated signaling cell activity cartilage finger embryonic mediated calcium homeostasis hematopoietic dna receptors epithelium ionocyte ligand-binding domain receptor-type
Features Gene ID: ENSDARG00000025032 Biological name :nr3c1 Synonyms : nr3c1 / nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Possible biological names infered from orthology : nuclear receptor subfamily 3 group C member 1 / P04150 Species: Danio rerio Chr. number: 14 Strand: -1 Band: Gene start: 23746710 Gene end: 23801389 Corresponding Affymetrix probe sets: Dr.16499.1.A1_at (Zebrafish Array) Dr.16499.2.S1_at (Zebrafish Array) Dr.16499.3.S1_at (Zebrafish Array) Dr.1903.1.A1_at (Zebrafish Array) Cross references: Ensembl peptide - ENSDARP00000148737 Ensembl peptide - ENSDARP00000054263 Ensembl peptide - ENSDARP00000104980 Ensembl peptide - ENSDARP00000111679 NCBI entrez gene - 553740
See in Manteia .
swissprot - F6PEW1 swissprot - Q1XHK0 swissprot - Q501U9 ZFIN ID - ZDB-GENE-050522-503 Ensembl - ENSDARG00000025032
See expression report in BioGPS See gene description in Wikigenes See co-cited genes in PubMed Ortholog prediction (from Ensembl )
Paralog prediction (from Ensembl ) nr3c2 / nuclear receptor subfamily 3, group C, member 2 / P08235* ENSDARG00000102082 37 ar / androgen receptor / P10275* / P19091* ENSDARG00000067976 30 pgr / progesterone receptor / P06401* / Q00175* ENSDARG00000035966 27 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor * ENSDARG00000004111 16 esr2a / estrogen receptor 2a / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta * ENSDARG00000016454 16 esr2b / estrogen receptor 2b / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta * ENSDARG00000034181 16 esrra / estrogen-related receptor alpha / O08580* / P11474* / Steroid hormone receptor ERR1 * ENSDARG00000069266 15 esrrb / esrrga / estrogen-related receptor beta ENSDARG00000004861 14 esrrgb / estrogen-related receptor gamma b ENSDARG00000011696 14 nr4a2b / nuclear receptor subfamily 4, group A, member 2b ENSDARG00000044532 14 nr4a3 / nuclear receptor subfamily 4, group A, member 3 / Q92570* / Q9QZB6* ENSDARG00000055854 14 esrrb / estrogen-related receptor beta / O95718* ENSDARG00000100847 14 nr4a2a / nuclear receptor subfamily 4, group A, member 2a / NR4A2* / Q06219* / P43354* / nuclear receptor subfamily 4 group A member 2* ENSDARG00000017007 13 nr4a1 / nuclear receptor subfamily 4, group A, member 1 / P12813* / P22736* ENSDARG00000000796 12 FO681288.3 / ESRRG* / P62508* / P62509* / estrogen related receptor gamma* / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA.* ENSDARG00000111043 8 esrrd / estrogen-related receptor delta ENSDARG00000015064 7
Protein motifs (from Interpro )
Gene Ontology (GO ) nitrogen compound metabolic process biosynthetic process cellular metabolic process primary metabolic process organic substance metabolic process response to stress response to abiotic stimulus cell communication response to endogenous stimulus response to chemical cellular response to stimulus anatomical structure development rhythmic behavior circadian rhythm regulation of biological quality establishment of localization cellular developmental process nitrogen compound metabolic process biosynthetic process cellular metabolic process primary metabolic process organic substance metabolic process response to stress response to abiotic stimulus cell communication response to endogenous stimulus response to chemical cellular response to stimulus anatomical structure development rhythmic behavior circadian rhythm regulation of biological quality establishment of localization cellular developmental process nitrogen compound metabolic process biosynthetic process cellular metabolic process primary metabolic process organic substance metabolic process response to stress response to abiotic stimulus cell communication response to endogenous stimulus response to chemical cellular response to stimulus anatomical structure development rhythmic behavior circadian rhythm regulation of biological quality establishment of localization cellular developmental process nitrogen compound metabolic process biosynthetic process cellular metabolic process primary metabolic process organic substance metabolic process response to stress response to abiotic stimulus cell communication response to endogenous stimulus response to chemical cellular response to stimulus anatomical structure development rhythmic behavior circadian rhythm regulation of biological quality establishment of localization cellular developmental process nitrogen compound metabolic process biosynthetic process cellular metabolic process primary metabolic process organic substance metabolic process response to stress response to abiotic stimulus cell communication response to endogenous stimulus response to chemical cellular response to stimulus anatomical structure development rhythmic behavior circadian rhythm regulation of biological quality establishment of localization cellular developmental process nitrogen compound metabolic process biosynthetic process cellular metabolic process primary metabolic process organic substance metabolic process response to stress response to abiotic stimulus cell communication response to endogenous stimulus response to chemical cellular response to stimulus anatomical structure development rhythmic behavior circadian rhythm regulation of biological quality establishment of localization cellular developmental process nitrogen compound metabolic process biosynthetic process cellular metabolic process primary metabolic process organic substance metabolic process response to stress response to abiotic stimulus cell communication response to endogenous stimulus response to chemical cellular response to stimulus anatomical structure development rhythmic behavior circadian rhythm regulation of biological quality establishment of localization cellular developmental process nitrogen compound metabolic process biosynthetic process cellular metabolic process primary metabolic process organic substance metabolic process response to stress response to abiotic stimulus cell communication response to endogenous stimulus response to chemical cellular response to stimulus anatomical structure development rhythmic behavior circadian rhythm regulation of biological quality establishment of localization cellular developmental process nitrogen compound metabolic process biosynthetic process cellular metabolic process primary metabolic process organic substance metabolic process response to stress response to abiotic stimulus cell communication response to endogenous stimulus response to chemical cellular response to stimulus anatomical structure development rhythmic behavior circadian rhythm regulation of biological quality establishment of localization cellular developmental process nitrogen compound metabolic process biosynthetic process cellular metabolic process primary metabolic process organic substance metabolic process response to stress response to abiotic stimulus cell communication response to endogenous stimulus response to chemical cellular response to stimulus anatomical structure development rhythmic behavior circadian rhythm regulation of biological quality establishment of localization cellular developmental process nitrogennitrogen compound metabolic process biosynthbiosynthetic process cellularcellular metabolic process primary primary metabolic process organic organic substance metabolic process responseresponse to stress responseresponse to abiotic stimulus cell comcell communication responseresponse to endogenous stimulus responseresponse to chemical cellularcellular response to stimulus anatomicanatomical structure development rhythmicrhythmic behavior circadiacircadian rhythm regulatiregulation of biological quality establisestablishment of localization cellularcellular developmental process organic cyclic compound binding heterocyclic compound binding DNA-binding transcription factor activity signaling receptor activity lipid binding ion binding organic cyclic compound binding heterocyclic compound binding DNA-binding transcription factor activity signaling receptor activity lipid binding ion binding organic cyclic compound binding heterocyclic compound binding DNA-binding transcription factor activity signaling receptor activity lipid binding ion binding organic cyclic compound binding heterocyclic compound binding DNA-binding transcription factor activity signaling receptor activity lipid binding ion binding organic cyclic compound binding heterocyclic compound binding DNA-binding transcription factor activity signaling receptor activity lipid binding ion binding organic cyclic compound binding heterocyclic compound binding DNA-binding transcription factor activity signaling receptor activity lipid binding ion binding organic cyclic compound binding heterocyclic compound binding DNA-binding transcription factor activity signaling receptor activity lipid binding ion binding organic cyclic compound binding heterocyclic compound binding DNA-binding transcription factor activity signaling receptor activity lipid binding ion binding organic cyclic compound binding heterocyclic compound binding DNA-binding transcription factor activity signaling receptor activity lipid binding ion binding organic cyclic compound binding heterocyclic compound binding DNA-binding transcription factor activity signaling receptor activity lipid binding ion binding organic cyclic compoundorganic cyclic compound binding heterocyclic compound bheterocyclic compound binding DNA-binding transcriptiDNA-binding transcription factor activity signaling receptor actisignaling receptor activity lipid bindinglipid binding ion bindingion binding cell organelle cell organelle cell organelle cell organelle cell organelle cell organelle cell organelle cell organelle cell organelle cell organelle cellcell organelleorganelle
Pathways (from Reactome )
Phenotype (from MGI , Zfin or HPO ) ZFA:0000006 ball ball edematous , abnormal
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ZFA:0000007 blood blood macrophage amount , ameliorated
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ZFA:0000008 brain brain decreased size , abnormal
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ZFA:0000037 anatomical structure anatomical structure amount , ameliorated anatomical structure increased amount , abnormal anatomical structure decreased amount , abnormal
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ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
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ZFA:0000054 pericardium pericardium edematous , abnormal
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ZFA:0000076 swim bladder swim bladder non-functional , abnormal
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ZFA:0000106 extension extension edematous , abnormal
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ZFA:0000107 eye eye decreased size , abnormal
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ZFA:0000114 heart heart structure , abnormal
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ZFA:0000123 liver liver decreased mass , abnormal liver size , exacerbated liver increased amount , abnormal
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ZFA:0000140 pancreas pancreas decreased size , abnormal
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ZFA:0000243 neuromast neuromast epithelium mislocalised , abnormal
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ZFA:0000368 integument integument proton export across plasma membrane occurrence , ameliorated integument proton export across plasma membrane decreased occurrence , abnormal integument keratinocyte decreased amount , abnormal integument mucus secreting cell decreased amount , abnormal
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ZFA:0000554 olfactory epithelium olfactory epithelium mislocalised , abnormal
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ZFA:0001078 thymus thymus T cell decreased amount , abnormal
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ZFA:0001089 myoseptum myoseptum melanocyte disorganized , abnormal
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ZFA:0001094 whole organism whole organism increased pigmentation , abnormal whole organism cortisol increased amount , abnormal whole organism decreased length , abnormal whole organism amount , ameliorated whole organism decreased amount , abnormal whole organism viability , abnormal whole organism increased amount , abnormal
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ZFA:0001114 head head decreased size , abnormal head epidermis mislocalised , abnormal
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ZFA:0001117 post-vent region post-vent region kinked , abnormal
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ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal Meckels cartilage disoriented , abnormal Meckels cartilage fused with palatoquadrate cartilage , abnormal
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ZFA:0001338 intestine intestine decreased width , abnormal
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ZFA:0001400 ceratohyal cartilage ceratohyal cartilage disoriented , abnormal ceratohyal cartilage fused with hypobranchial cartilage , abnormal
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ZFA:0001405 ethmoid cartilage ethmoid cartilage curled , abnormal ethmoid cartilage retracted , abnormal
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ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
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ZFA:0005035 subintestinal vein subintestinal vein absent , abnormal subintestinal vein decreased amount , abnormal
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ZFA:0005060 trabecular layer of ventricle trabecular layer of ventricle decreased object quality , abnormal
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ZFA:0005126 intestinal bulb epithelium intestinal bulb epithelium decreased thickness , abnormal
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ZFA:0005326 NaK ionocyte NaK ionocyte decreased amount , abnormal
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ZFA:0005327 vH ionocyte vH ionocyte decreased amount , abnormal
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ZFA:0005762 subcutaneous fat subcutaneous fat increased amount , abnormal
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ZFA:0009034 epithelial cell epithelial cell mislocalised , abnormal
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ZFA:0009141 macrophage macrophage amount , ameliorated
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ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
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Interacting proteins (from Reactome ) ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein... / complex ENSDARG00000008447 fkbp4 / FK506 binding protein 4 / P30416* / Q02790* / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed* / complex ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I* / reaction ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 * / reaction / complex ENSDARG00000025032 nr3c1 / nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) / P04150* / nuclear receptor subfamily 3 group C member 1* / complex ENSDARG00000037284 ptges3a / prostaglandin E synthase 3a (cytosolic) / PTGES3* / Q9R0Q7* / Q15185* / prostaglandin E synthase 3* / complex ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I* / reaction
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