ENSDARG00000025032


Danio rerio

Features
Gene ID: ENSDARG00000025032
  
Biological name :nr3c1
  
Synonyms : nr3c1 / nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  
Possible biological names infered from orthology : nuclear receptor subfamily 3 group C member 1 / P04150
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 23746710
Gene end: 23801389
  
Corresponding Affymetrix probe sets: Dr.16499.1.A1_at (Zebrafish Array)   Dr.16499.2.S1_at (Zebrafish Array)   Dr.16499.3.S1_at (Zebrafish Array)   Dr.1903.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000148737
Ensembl peptide - ENSDARP00000054263
Ensembl peptide - ENSDARP00000104980
Ensembl peptide - ENSDARP00000111679
NCBI entrez gene - 553740     See in Manteia.
swissprot - F6PEW1
swissprot - Q1XHK0
swissprot - Q501U9
ZFIN ID - ZDB-GENE-050522-503
Ensembl - ENSDARG00000025032
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NR3C1ENSGALG00000032992Gallus gallus
 NR3C1ENSG00000113580Homo sapiens
 Nr3c1ENSMUSG00000024431Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nr3c2 / nuclear receptor subfamily 3, group C, member 2 / P08235*ENSDARG0000010208237
ar / androgen receptor / P10275* / P19091*ENSDARG0000006797630
pgr / progesterone receptor / P06401* / Q00175*ENSDARG0000003596627
esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *ENSDARG0000000411116
esr2a / estrogen receptor 2a / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *ENSDARG0000001645416
esr2b / estrogen receptor 2b / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *ENSDARG0000003418116
esrra / estrogen-related receptor alpha / O08580* / P11474* / Steroid hormone receptor ERR1 *ENSDARG0000006926615
esrrb / esrrga / estrogen-related receptor betaENSDARG0000000486114
esrrgb / estrogen-related receptor gamma bENSDARG0000001169614
nr4a2b / nuclear receptor subfamily 4, group A, member 2bENSDARG0000004453214
nr4a3 / nuclear receptor subfamily 4, group A, member 3 / Q92570* / Q9QZB6*ENSDARG0000005585414
esrrb / estrogen-related receptor beta / O95718*ENSDARG0000010084714
nr4a2a / nuclear receptor subfamily 4, group A, member 2a / NR4A2* / Q06219* / P43354* / nuclear receptor subfamily 4 group A member 2*ENSDARG0000001700713
nr4a1 / nuclear receptor subfamily 4, group A, member 1 / P12813* / P22736*ENSDARG0000000079612
FO681288.3 / ESRRG* / P62508* / P62509* / estrogen related receptor gamma* / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA.*ENSDARG000001110438
esrrd / estrogen-related receptor deltaENSDARG000000150647


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001409  Glucocorticoid receptor
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0019222 regulation of metabolic process IMP
 biological_processGO:0033555 multicellular organismal response to stress IEP
 biological_processGO:0036367 light adaption IMP
 biological_processGO:0042921 glucocorticoid receptor signaling pathway IEA
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043402 glucocorticoid mediated signaling pathway IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0048512 circadian behavior IGI
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0051384 response to glucocorticoid IMP
 biological_processGO:0051414 response to cortisol IMP
 biological_processGO:0055074 calcium ion homeostasis IMP
 biological_processGO:0055078 sodium ion homeostasis IMP
 biological_processGO:0070509 calcium ion import IMP
 biological_processGO:0071548 response to dexamethasone IDA
 biological_processGO:0120029 proton export across plasma membrane IMP
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004883 glucocorticoid receptor activity IDA
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000006 ball ball edematous , abnormal
Show

 ZFA:0000007 blood blood macrophage amount , ameliorated
Show

 ZFA:0000008 brain brain decreased size , abnormal
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 ZFA:0000037 anatomical structure anatomical structure amount , ameliorated
anatomical structure increased amount , abnormal
anatomical structure decreased amount , abnormal
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 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000076 swim bladder swim bladder non-functional , abnormal
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 ZFA:0000106 extension extension edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart structure , abnormal
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 ZFA:0000123 liver liver decreased mass , abnormal
liver size , exacerbated
liver increased amount , abnormal
Show

 ZFA:0000140 pancreas pancreas decreased size , abnormal
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 ZFA:0000243 neuromast neuromast epithelium mislocalised , abnormal
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 ZFA:0000368 integument integument proton export across plasma membrane occurrence , ameliorated
integument proton export across plasma membrane decreased occurrence , abnormal
integument keratinocyte decreased amount , abnormal
integument mucus secreting cell decreased amount , abnormal
Show

 ZFA:0000554 olfactory epithelium olfactory epithelium mislocalised , abnormal
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 ZFA:0001078 thymus thymus T cell decreased amount , abnormal
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 ZFA:0001089 myoseptum myoseptum melanocyte disorganized , abnormal
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 ZFA:0001094 whole organism whole organism increased pigmentation , abnormal
whole organism cortisol increased amount , abnormal
whole organism decreased length , abnormal
whole organism amount , ameliorated
whole organism decreased amount , abnormal
whole organism viability , abnormal
whole organism increased amount , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head epidermis mislocalised , abnormal
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 ZFA:0001117 post-vent region post-vent region kinked , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
Meckels cartilage disoriented , abnormal
Meckels cartilage fused with palatoquadrate cartilage , abnormal
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 ZFA:0001338 intestine intestine decreased width , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage disoriented , abnormal
ceratohyal cartilage fused with hypobranchial cartilage , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage curled , abnormal
ethmoid cartilage retracted , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
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 ZFA:0005035 subintestinal vein subintestinal vein absent , abnormal
subintestinal vein decreased amount , abnormal
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 ZFA:0005060 trabecular layer of ventricle trabecular layer of ventricle decreased object quality , abnormal
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 ZFA:0005126 intestinal bulb epithelium intestinal bulb epithelium decreased thickness , abnormal
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 ZFA:0005326 NaK ionocyte NaK ionocyte decreased amount , abnormal
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 ZFA:0005327 vH ionocyte vH ionocyte decreased amount , abnormal
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 ZFA:0005762 subcutaneous fat subcutaneous fat increased amount , abnormal
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 ZFA:0009034 epithelial cell epithelial cell mislocalised , abnormal
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 ZFA:0009141 macrophage macrophage amount , ameliorated
Show

 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / complex
 ENSDARG00000008447 fkbp4 / FK506 binding protein 4 / P30416* / Q02790* / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed*  / complex
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / reaction / complex
 ENSDARG00000025032 nr3c1 / nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) / P04150* / nuclear receptor subfamily 3 group C member 1*  / complex
 ENSDARG00000037284 ptges3a / prostaglandin E synthase 3a (cytosolic) / PTGES3* / Q9R0Q7* / Q15185* / prostaglandin E synthase 3*  / complex
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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