ENSDARG00000016454


Danio rerio

Features
Gene ID: ENSDARG00000016454
  
Biological name :esr2a
  
Synonyms : esr2a / estrogen receptor 2a
  
Possible biological names infered from orthology : ESR2 / estrogen receptor 2 / Estrogen receptor beta / O08537 / Q92731
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 21583639
Gene end: 21635659
  
Corresponding Affymetrix probe sets: Dr.11727.1.S1_at (Zebrafish Array)   Dr.11727.1.S2_at (Zebrafish Array)   NM_180966_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000017514
Ensembl peptide - ENSDARP00000110930
NCBI entrez gene - 317734     See in Manteia.
RefSeq - NM_180966
RefSeq Peptide - NP_851297
swissprot - Q7ZU32
ZFIN ID - ZDB-GENE-030116-2
Ensembl - ENSDARG00000016454
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ESR2ENSGALG00000011801Gallus gallus
 ESR2ENSG00000140009Homo sapiens
 Esr2ENSMUSG00000021055Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
esr2b / estrogen receptor 2b / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *ENSDARG0000003418157
esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *ENSDARG0000000411143
esrrb / esrrga / estrogen-related receptor betaENSDARG0000000486127
esrra / estrogen-related receptor alpha / O08580* / P11474* / Steroid hormone receptor ERR1 *ENSDARG0000006926627
esrrb / estrogen-related receptor beta / O95718*ENSDARG0000010084727
esrrgb / estrogen-related receptor gamma bENSDARG0000001169625
nr3c1 / nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) / P04150* / nuclear receptor subfamily 3 group C member 1*ENSDARG0000002503222
nr3c2 / nuclear receptor subfamily 3, group C, member 2 / P08235*ENSDARG0000010208222
pgr / progesterone receptor / P06401* / Q00175*ENSDARG0000003596620
nr4a1 / nuclear receptor subfamily 4, group A, member 1 / P12813* / P22736*ENSDARG0000000079619
nr4a2a / nuclear receptor subfamily 4, group A, member 2a / NR4A2* / Q06219* / P43354* / nuclear receptor subfamily 4 group A member 2*ENSDARG0000001700719
ar / androgen receptor / P10275* / P19091*ENSDARG0000006797619
nr4a2b / nuclear receptor subfamily 4, group A, member 2bENSDARG0000004453218
nr4a3 / nuclear receptor subfamily 4, group A, member 3 / Q92570* / Q9QZB6*ENSDARG0000005585418
FO681288.3 / ESRRG* / P62508* / P62509* / estrogen related receptor gamma* / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA.*ENSDARG0000011104315
esrrd / estrogen-related receptor deltaENSDARG0000001506412


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR021064  Estrogen receptor beta, N-terminal
 IPR024178  Oestrogen receptor/oestrogen-related receptor
 IPR028355  Estrogen receptor beta/gamma


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043627 response to estrogen IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0030284 estrogen receptor activity IDA
 molecular_functionGO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990239 steroid hormone binding IDA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Nuclear Receptor transcription pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ESR-mediated signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic , abnormal
brain decreased size , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000084 yolk yolk increased volume , abnormal
Show

 ZFA:0000106 extension extension decreased size , abnormal
extension edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000243 neuromast neuromast decreased amount , abnormal
neuromast absent , abnormal
Show

 ZFA:0001058 caudal fin caudal fin hypoplastic , abnormal
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 ZFA:0001094 whole organism whole organism dead , abnormal
whole organism circling , abnormal
whole organism apoptotic , abnormal
whole organism viability , abnormal
whole organism decreased size , abnormal
Show

 ZFA:0001115 trunk trunk curved , abnormal
Show

 ZFA:0001117 post-vent region post-vent region increased curvature , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage stubby , abnormal
Show

 ZFA:0001216 splanchnocranium splanchnocranium morphology , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage bent , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage orientation basibranchial , abnormal
Show

 ZFA:0001486 epithelium epithelium ventral region hypertrophic , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage decreased length , abnormal
Show

 ZFA:0005035 subintestinal vein subintestinal vein hypoplastic , abnormal
subintestinal vein aplastic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / complex
 ENSDARG00000016454 esr2a / estrogen receptor 2a / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *  / complex / reaction
 ENSDARG00000034181 esr2b / estrogen receptor 2b / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *  / complex / reaction
 ENSDARG00000038835 ppid / peptidylprolyl isomerase D / Q08752* / Q9CR16* / peptidylprolyl isomerase D (cyclophilin D)*  / complex
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex / reaction
 ENSDARG00000037284 ptges3a / prostaglandin E synthase 3a (cytosolic) / PTGES3* / Q9R0Q7* / Q15185* / prostaglandin E synthase 3*  / complex






 

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