ENSDARG00000003462


Danio rerio

Features
Gene ID: ENSDARG00000003462
  
Biological name :fech
  
Synonyms : fech / ferrochelatase
  
Possible biological names infered from orthology : Mus musculus ferrochelatase (Fech), transcript variant 2, mRNA. / P22830
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 1647990
Gene end: 1670264
  
Corresponding Affymetrix probe sets: Dr.10447.1.S1_at (Zebrafish Array)   NM_131631_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000125028
NCBI entrez gene - 58215     See in Manteia.
RefSeq - NM_131631
RefSeq Peptide - NP_571706
swissprot - F1R362
ZFIN ID - ZDB-GENE-000928-1
Ensembl - ENSDARG00000003462
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FECHENSGALG00000038461Gallus gallus
 FECHENSG00000066926Homo sapiens
 FechENSMUSG00000024588Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001015  Ferrochelatase
 IPR019772  Ferrochelatase, active site
 IPR033644  Ferrochelatase, C-terminal
 IPR033659  Ferrochelatase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006779 porphyrin-containing compound biosynthetic process IEA
 biological_processGO:0006783 heme biosynthetic process IBA
 biological_processGO:0043249 erythrocyte maturation IMP
 cellular_componentGO:0005739 mitochondrion IBA
 molecular_functionGO:0004325 ferrochelatase activity IMP
 molecular_functionGO:0016829 lyase activity IEA


Pathways (from Reactome)
Pathway description
Heme biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood quality , abnormal
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 ZFA:0000112 gut gut quality , abnormal
Show

 ZFA:0000123 liver liver quality , abnormal
liver nucleate erythrocyte broken , abnormal
liver has extra parts of type erythroid lineage cell , abnormal
Show

 ZFA:0000529 kidney kidney has extra parts of type erythroid lineage cell , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
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 ZFA:0001439 anatomical system anatomical system quality , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte absent , abnormal
nucleate erythrocyte photosensitive , abnormal
nucleate erythrocyte broken , abnormal
nucleate erythrocyte decreased amount , abnormal
nucleate erythrocyte autofluorescence , abnormal
nucleate erythrocyte increased fluorescence , abnormal
nucleate erythrocyte hemoglobin complex composition , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003462 fech / ferrochelatase / P22830* / Mus musculus ferrochelatase (Fech), transcript variant 2, mRNA.*  / complex






 

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