ENSDARG00000004173


Danio rerio

Features
Gene ID: ENSDARG00000004173
  
Biological name :copa
  
Synonyms : coatomer protein complex, subunit alpha / copa
  
Possible biological names infered from orthology : Coatomer subunit alpha Xenin Proxenin / P53621 / Q8CIE6
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 37176814
Gene end: 37206080
  
Corresponding Affymetrix probe sets: Dr.2921.1.A1_at (Zebrafish Array)   Dr.8447.1.S1_at (Zebrafish Array)   NM_001001941_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000048276
Ensembl peptide - ENSDARP00000143620
NCBI entrez gene - 260439     See in Manteia.
RefSeq - NM_001001941
RefSeq Peptide - NP_001001941
swissprot - F1QDQ1
swissprot - A0A286Y8Z3
ZFIN ID - ZDB-GENE-020905-2
Ensembl - ENSDARG00000004173
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 COPAENSGALG00000009153Gallus gallus
 COPAENSG00000122218Homo sapiens
 CopaENSMUSG00000026553Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
wdr37 / WD repeat domain 37 / Q8CBE3* / Q9Y2I8*ENSDARG000000746118


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR006692  Coatomer, WD associated region
 IPR010714  Coatomer, alpha subunit, C-terminal
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016391  Coatomer alpha subunit
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0061053 somite development IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030126 COPI vesicle coat IEA
 molecular_functionGO:0005198 structural molecule activity IEA


Pathways (from Reactome)
Pathway description
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
Show

 ZFA:0000084 yolk yolk quality , abnormal
yolk morphology , abnormal
Show

 ZFA:0000135 notochord notochord undulate , abnormal
notochord quality , abnormal
notochord undifferentiated , abnormal
notochord decreased length , abnormal
notochord apoptotic , abnormal
notochord basement membrane decreased thickness , abnormal
notochord basement membrane disorganized , abnormal
notochord basal lamina absent , abnormal
notochord endoplasmic reticulum swollen , abnormal
notochord Golgi apparatus structure , abnormal
notochord poorly differentiated , abnormal
notochord cell structure , abnormal
Show

 ZFA:0000155 somite somite size , abnormal
somite condensed , abnormal
somite morphology , abnormal
somite quality , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II defasciculated , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism necrotic , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism degenerate , abnormal
Show

 ZFA:0001114 head head cuboid , abnormal
head morphology , abnormal
Show

 ZFA:0001115 trunk trunk melanosome absent , abnormal
trunk decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region melanosome absent , abnormal
Show

 ZFA:0007009 nerve nerve glial cell (sensu Vertebrata) branched , abnormal
Show

 ZFA:0009091 melanocyte melanocyte melanosome absent , abnormal
Show

 ZFA:0009114 muscle cell muscle cell endoplasmic reticulum swollen , abnormal
muscle cell Golgi apparatus structure , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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