ENSG00000122218


Homo sapiens

Features
Gene ID: ENSG00000122218
  
Biological name :COPA
  
Synonyms : coatomer protein complex subunit alpha / COPA / P53621
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.2
Gene start: 160289273
Gene end: 160343400
  
Corresponding Affymetrix probe sets: 1559862_at (Human Genome U133 Plus 2.0 Array)   208684_at (Human Genome U133 Plus 2.0 Array)   214336_s_at (Human Genome U133 Plus 2.0 Array)   214337_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000241704
Ensembl peptide - ENSP00000357048
NCBI entrez gene - 1314     See in Manteia.
OMIM - 601924
RefSeq - NM_001098398
RefSeq - NM_004371
RefSeq Peptide - NP_001091868
RefSeq Peptide - NP_004362
swissprot - P53621
Ensembl - ENSG00000122218
  
Related genetic diseases (OMIM): 616414 - {Autoimmune interstitial lung, joint, and kidney disease}, 616414
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 copaENSDARG00000004173Danio rerio
 COPAENSGALG00000009153Gallus gallus
 CopaENSMUSG00000026553Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WDR37 / Q9Y2I8 / WD repeat domain 37ENSG000000470568


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR006692  Coatomer, WD associated region
 IPR010714  Coatomer, alpha subunit, C-terminal
 IPR011048  Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016391  Coatomer alpha subunit
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA
 biological_processGO:0006891 intra-Golgi vesicle-mediated transport IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0030157 pancreatic juice secretion IDA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030126 COPI vesicle coat IDA
 cellular_componentGO:0030133 transport vesicle TAS
 cellular_componentGO:0030663 COPI-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129083 COPB1 / P53618 / coatomer protein complex subunit beta 1  / complex
 ENSG00000111481 COPZ1 / P61923 / coatomer protein complex subunit zeta 1  / complex
 ENSG00000138768 USO1 / O60763 / USO1 vesicle transport factor  / complex / reaction
 ENSG00000105669 COPE / O14579 / coatomer protein complex subunit epsilon  / complex
 ENSG00000095139 ARCN1 / P48444 / archain 1  / complex
 ENSG00000168374 ARF4 / P18085 / ADP ribosylation factor 4  / complex / reaction
 ENSG00000174903 RAB1B / Q9H0U4 / RAB1B, member RAS oncogene family  / complex / reaction
 ENSG00000181789 COPG1 / Q9Y678 / coatomer protein complex subunit gamma 1  / complex
 ENSG00000158623 COPG2 / Q9UBF2 / coatomer protein complex subunit gamma 2  / complex
 ENSG00000184432 COPB2 / P35606 / coatomer protein complex subunit beta 2  / complex
 ENSG00000107862 GBF1 / Q92538 / golgi brefeldin A resistant guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000005243 COPZ2 / Q9P299 / coatomer protein complex subunit zeta 2  / complex






 

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