ENSDARG00000004343


Danio rerio

Features
Gene ID: ENSDARG00000004343
  
Biological name :nelfe
  
Synonyms : negative elongation factor complex member E / nelfe
  
Possible biological names infered from orthology : negative elongation factor complex member E, Rdbp / P18615 / P19426
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 26922780
Gene end: 26932829
  
Corresponding Affymetrix probe sets: Dr.25733.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000154852
Ensembl peptide - ENSDARP00000124025
Ensembl peptide - ENSDARP00000124298
Ensembl peptide - ENSDARP00000124545
Ensembl peptide - ENSDARP00000124636
Ensembl peptide - ENSDARP00000150604
NCBI entrez gene - 436648     See in Manteia.
RefSeq - XM_021468046
swissprot - F8W2R3
swissprot - F8W3U9
swissprot - F8W3Z7
swissprot - Q1LWQ2
ZFIN ID - ZDB-GENE-040718-69
Ensembl - ENSDARG00000004343
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NELFEENSG00000204356Homo sapiens
 NelfeENSMUSG00000024369Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR033102  Negative elongation factor E
 IPR034637  Negative elongation factor E, RNA recognition motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:1901534 positive regulation of hematopoietic progenitor cell differentiation IMP
 biological_processGO:1902038 positive regulation of hematopoietic stem cell differentiation IMP
 cellular_componentGO:0032021 NELF complex IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000061411 nelfa / negative elongation factor complex member A / Q8BG30* / Q9H3P2* / Negative elongation factor A *  / complex
 ENSDARG00000014898 ncbp2 / Q8JGR6 / nuclear cap binding protein subunit 2 / Q9CQ49* / NCBP2L* / P52298* / A6PVI3* / nuclear cap binding protein subunit 2 like*  / complex / reaction
 ENSDARG00000042724 supt5h / SPT5 homolog, DSIF elongation factor subunit / Supt5* / O55201* / O00267* / Transcription elongation factor SPT5 *  / complex / reaction
 ENSDARG00000113969 Q6DGQ0 / supt4h1 / SPT4 homolog, DSIF elongation factor subunit / P63272*  / complex / reaction






 

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