ENSDARG00000005191


Danio rerio

Features
Gene ID: ENSDARG00000005191
  
Biological name :ahcy
  
Synonyms : adenosylhomocysteinase / ahcy
  
Possible biological names infered from orthology : Gm4737 / P23526 / P50247 / predicted gene 4737
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 49926115
Gene end: 49966288
  
Corresponding Affymetrix probe sets: Dr.25468.1.A1_at (Zebrafish Array)   Dr.6924.1.S1_at (Zebrafish Array)   NM_199218_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000002844
NCBI entrez gene - 387530     See in Manteia.
RefSeq - NM_199218
RefSeq Peptide - NP_954688
swissprot - Q803T5
ZFIN ID - ZDB-GENE-031219-6
Ensembl - ENSDARG00000005191
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AHCYENSGALG00000033677Gallus gallus
 AHCYENSG00000101444Homo sapiens
 AhcyENSMUSG00000027597Mus musculus
 Gm4737ENSMUSG00000048087Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ahcyl2 / adenosylhomocysteinase-like 2 / Q68FL4* / Q96HN2* / S-adenosylhomocysteine hydrolase-like 2*ENSDARG0000003934351
ahcyl1 / adenosylhomocysteinase-like 1 / O43865* / Q80SW1* / Mus musculus S-adenosylhomocysteine hydrolase-like 1 (Ahcyl1), transcript variant 5, mRNA.*ENSDARG0000005633151
zgc:158222 / Q96HN2* / Q68FL4* / AHCYL2* / adenosylhomocysteinase like 2* / S-adenosylhomocysteine hydrolase-like 2*ENSDARG0000005187347


Protein motifs (from Interpro)
Interpro ID Name
 IPR000043  Adenosylhomocysteinase-like
 IPR015878  S-adenosyl-L-homocysteine hydrolase, NAD binding domain
 IPR016040  NAD(P)-binding domain
 IPR020082  S-adenosyl-L-homocysteine hydrolase, conserved site
 IPR034373  Adenosylhomocysteinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0019510 S-adenosylhomocysteine catabolic process IEA
 biological_processGO:0033353 S-adenosylmethionine cycle IMP
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0004013 adenosylhomocysteinase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Methylation
Sulfur amino acid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000123 liver liver decreased size , abnormal
liver nucleus increased size , abnormal
liver lipid droplet present , abnormal
liver size , ameliorated
liver lipid increased amount , abnormal
Show

 ZFA:0000208 gall bladder gall bladder decreased functionality , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas quality , abnormal
Show

 ZFA:0005164 bile ductule bile ductule degenerate , abnormal
bile ductule unlumenized , abnormal
Show

 ZFA:0005169 intrahepatic bile duct intrahepatic bile duct decreased branchiness , abnormal
Show

 ZFA:0009091 melanocyte melanocyte quality , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte mitochondrion structure , abnormal
hepatocyte mitochondrial crista condensed , abnormal
hepatocyte increased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005191 ahcy / adenosylhomocysteinase / Gm4737* / P23526* / P50247* / predicted gene 4737*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr