ENSDARG00000005451


Danio rerio
activitygdi2gtpaserabinhibitorproteingdpregulationgdp-dissociationgdidissociationfadnadp-bindingdomainsmallmediatedsignaltransductiontransportcatalyticcytoplasmactivatorrhocycleneutrophildegranulationgefsexchangegtp

Features
Gene ID: ENSDARG00000005451
  
Biological name :gdi2
  
Synonyms : gdi2 / GDP dissociation inhibitor 2
  
Possible biological names infered from orthology : P50395 / Q61598 / Rab GDP dissociation inhibitor beta
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 11464255
Gene end: 11477630
  
Corresponding Affymetrix probe sets: Dr.5529.1.S1_at (Zebrafish Array)   NM_199655_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000009258
NCBI entrez gene - 323765     See in Manteia.
RefSeq - NM_199655
RefSeq Peptide - NP_955949
swissprot - Q6TNT9
ZFIN ID - ZDB-GENE-030131-2485
Ensembl - ENSDARG00000005451
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GDI2ENSGALG00000008169Gallus gallus
 GDI2ENSG00000057608Homo sapiens
 Gdi2ENSMUSG00000021218Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gdi1 / GDP dissociation inhibitor 1 / P31150* / P50396* / Rab GDP dissociation inhibitor alpha *ENSDARG0000005612285
zgc:112334ENSDARG0000010292465
chm / choroideremia (Rab escort protein 1) / CHML* / P26374* / P24386* / choroideremia-like* / CHM, Rab escort protein 1* / CHM like, Rab escort protein 2* / choroidermia (RAB escort protein 1)*ENSDARG0000000384524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000806  Rab GDI protein
 IPR018203  GDP dissociation inhibitor
 IPR023753  FAD/NAD(P)-binding domain


Gene Ontology (GO)
cell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationregulation of molecular functioncell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationregulation of molecular functioncell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationregulation of molecular functioncell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationregulation of molecular functioncell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationregulation of molecular functioncell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationregulation of molecular functioncell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationregulation of molecular functioncell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationregulation of molecular functioncell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationregulation of molecular functioncell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationregulation of molecular functioncell communicationcell communicationcellular response to stimulucellular response to stimulusmacromolecule localizationmacromolecule localizationestablishment of localizatioestablishment of localizationregulation of molecular funcregulation of molecular function
enzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activity
cellcellcellcellcellcellcellcellcellcellcellcell
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005092 GDP-dissociation inhibitor activity IEA
 molecular_functionGO:0005093 Rab GDP-dissociation inhibitor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Neutrophil degranulation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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