ENSDARG00000006272


Danio rerio

Features
Gene ID: ENSDARG00000006272
  
Biological name :mpp5a
  
Synonyms : membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5) / mpp5a
  
Possible biological names infered from orthology : membrane palmitoylated protein 5 / membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) / MPP5 / Q8N3R9 / Q9JLB2
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 34186632
Gene end: 34239514
  
Corresponding Affymetrix probe sets: Dr.18301.1.S1_at (Zebrafish Array)   Dr.18838.1.S1_at (Zebrafish Array)   NM_194363_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000015684
Ensembl peptide - ENSDARP00000123304
Ensembl peptide - ENSDARP00000151296
NCBI entrez gene - 252845     See in Manteia.
RefSeq - NM_194363
RefSeq - XM_009293174
RefSeq Peptide - NP_919344
swissprot - Q1LVF4
ZFIN ID - ZDB-GENE-020712-1
Ensembl - ENSDARG00000006272
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MPP5ENSGALG00000009581Gallus gallus
 MPP5ENSG00000072415Homo sapiens
 Mpp5ENSMUSG00000021112Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mpp5b / membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5) / MPP5* / Q8N3R9* / Q9JLB2* / membrane palmitoylated protein 5* / membrane protein, palmitoylated 5 (MAGUK p55 subf...ENSDARG0000000472150
mpp7a / Q6P0D7 / membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7) / MPP7* / Q5T2T1* / membrane palmitoylated protein 7* / MAGUK p55 subfamily member 7 isoform 2 *ENSDARG0000010247030
mpp3a / membrane protein, palmitoylated 3a (MAGUK p55 subfamily member 3) / MPP3* / Q13368* / membrane palmitoylated protein 3*ENSDARG0000001518428
mpp3b / membrane protein, palmitoylated 3b (MAGUK p55 subfamily member 3) / MPP3* / Q13368* / membrane palmitoylated protein 3*ENSDARG0000006266728
mpp4a / membrane protein, palmitoylated 4a (MAGUK p55 subfamily member 4) / MPP4* / Q6P7F1* / Q96JB8* / MAGUK p55 subfamily member 4 * / membrane palmitoylated protein 4*ENSDARG0000005822226
mpp2b / membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2) / MPP2* / Q14168* / Q9WV34* / membrane palmitoylated protein 2* / Mus musculus membrane protein, palmitoylated 2 (M...ENSDARG0000001095725
mpp6b / membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6) / MPP6* / Q9JLB0* / Q9NZW5* / membrane palmitoylated protein 6* / membrane protein, palmitoylated 6 (MAGUK p55 subf...ENSDARG0000002976125
mpp2a / membrane protein, palmitoylated 2a (MAGUK p55 subfamily member 2) / MPP2* / Q14168* / Q9WV34* / membrane palmitoylated protein 2* / Mus musculus membrane protein, palmitoylated 2 (M...ENSDARG0000005345325
mpp6a / membrane protein, palmitoylated 6a (MAGUK p55 subfamily member 6) / MPP6* / Q9JLB0* / Q9NZW5* / membrane palmitoylated protein 6* / membrane protein, palmitoylated 6 (MAGUK p55 subf...ENSDARG0000005689225
caska / calcium/calmodulin-dependent serine protein kinase a / CASK* / O70589* / O14936* / Peripheral plasma membrane protein CASK * / calcium/calmodulin dependent serine protein kinase*ENSDARG0000005980924
dlg3 / discs, large homolog 3 (Drosophila) / P70175* / Q92796* / Disks large homolog 3 * / discs large MAGUK scaffold protein 3*ENSDARG0000007679623
dlg1 / Q5PYH6 / discs, large homolog 1 (Drosophila) / Q12959* / Q811D0* / Disks large homolog 1 * / discs large MAGUK scaffold protein 1*ENSDARG0000000967722
dlg2 / discs, large homolog 2 (Drosophila) / Q15700* / Q91XM9* / Disks large homolog 2 * / discs large MAGUK scaffold protein 2*ENSDARG0000009932322
si:ch211-222n4.6 / MPP4* / Q6P7F1* / Q96JB8* / MAGUK p55 subfamily member 4 * / membrane palmitoylated protein 4*ENSDARG0000000938621
si:ch211-222n4.6 / MPP4 (1 of many) / MPP4* / Q6P7F1* / Q96JB8* / MAGUK p55 subfamily member 4 * / membrane palmitoylated protein 4*ENSDARG0000007687221
dlg1l / Q5PYH5 / discs, large (Drosophila) homolog 1, like / DLG1* / Q12959* / Q811D0* / Disks large homolog 1 * / discs large MAGUK scaffold protein 1*ENSDARG0000010221621
mpp1 / membrane protein, palmitoylated 1 / P70290* / Q00013* / membrane protein, palmitoylated* / membrane palmitoylated protein 1*ENSDARG0000010528721
caskb / calcium/calmodulin-dependent serine protein kinase b / CASK* / O70589* / O14936* / Peripheral plasma membrane protein CASK * / calcium/calmodulin dependent serine protein kinase*ENSDARG0000010011920
dlg4a / discs, large homolog 4a (Drosophila) / DLG4* / P78352* / discs large MAGUK scaffold protein 4*ENSDARG0000004192619
dlg4b / discs, large homolog 4b (Drosophila)ENSDARG0000003938517


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR004172  L27 domain
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR014775  L27 domain, C-terminal
 IPR015145  L27-N
 IPR020590  Guanylate kinase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031185  MAGUK p55 subfamily member 5
 IPR035601  MPP5, SH3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0070830 bicellular tight junction assembly IEA
 biological_processGO:0090162 establishment of epithelial cell polarity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
brain morphology , abnormal
brain shape , abnormal
brain surface feature shape , abnormal
Show

 ZFA:0000029 hindbrain hindbrain quality , abnormal
Show

 ZFA:0000035 lens lens structure , abnormal
lens perforate , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary morphology , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer disorganized , abnormal
retinal neural layer positional polarity , abnormal
retinal neural layer apical junction complex mislocalised , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000059 postoptic commissure postoptic commissure morphology , abnormal
postoptic commissure defasciculated , abnormal
postoptic commissure astrocyte mislocalised , abnormal
Show

 ZFA:0000107 eye eye quality , abnormal
eye proliferative region increased size , abnormal
eye proliferative region mislocalised , abnormal
Show

 ZFA:0000109 forebrain forebrain commissural neuron axon guidance disrupted , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle decreased diameter , abnormal
fourth ventricle decreased volume , abnormal
Show

 ZFA:0000112 gut gut decreased size , abnormal
Show

 ZFA:0000114 heart heart immature , abnormal
heart edematous , abnormal
heart quality , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium patchy , abnormal
retinal pigmented epithelium quality , abnormal
retinal pigmented epithelium poorly differentiated , abnormal
retinal pigmented epithelium perforate , abnormal
Show

 ZFA:0000152 retina retina disorganized , abnormal
retina immature , abnormal
retina quality , abnormal
retina apoptotic , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000360 heart tube heart tube decreased length , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II defasciculated , abnormal
Show

 ZFA:0000640 cornea cornea structure , abnormal
cornea anatomical surface structure , abnormal
Show

 ZFA:0000938 central canal central canal malformed , abnormal
Show

 ZFA:0001094 whole organism whole organism bent , abnormal
whole organism shape , abnormal
whole organism curved , abnormal
whole organism curved ventral , abnormal
Show

 ZFA:0001108 anterior commissure anterior commissure morphology , abnormal
anterior commissure defasciculated , abnormal
anterior commissure astrocyte mislocalised , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head surface feature shape , abnormal
Show

 ZFA:0001115 trunk trunk curved ventral , abnormal
trunk curved dorsal , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curled , abnormal
Show

 ZFA:0001135 neural tube neural tube malformed , abnormal
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 ZFA:0001202 optic cup optic cup neuron decreased amount , abnormal
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 ZFA:0001261 ventricular system ventricular system decreased size , abnormal
Show

 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer patchy , abnormal
Show

 ZFA:0001330 retinal outer plexiform layer retinal outer plexiform layer patchy , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001655 pericardial cavity pericardial cavity increased size , abnormal
Show

 ZFA:0001673 pronephric podocyte pronephric podocyte physical object quality , abnormal
Show

 ZFA:0001683 corneal epithelium corneal epithelium saccular , abnormal
corneal epithelium desmosome decreased amount , abnormal
Show

 ZFA:0001685 corneal stroma corneal stroma disorganized , abnormal
Show

 ZFA:0001695 dorsolateral motor nucleus of vagal nerve dorsolateral motor nucleus of vagal nerve malformed , abnormal
Show

 ZFA:0007067 vagal ganglion vagal ganglion fused with vagal ganglion , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
Show

 ZFA:0009091 melanocyte melanocyte quality , abnormal
Show

 ZFA:0009264 corneal epithelial cell corneal epithelial cell cellular adhesivity corneal epithelial cell , abnormal
Show

 ZFA:0009306 neuroepithelial cell neuroepithelial cell positional polarity , abnormal
neuroepithelial cell apical part of cell decreased width , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell apical junction complex structure , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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