ENSDARG00000008165


Danio rerio

Features
Gene ID: ENSDARG00000008165
  
Biological name :caspa
  
Synonyms : caspa / caspase a
  
Possible biological names infered from orthology : CASP1 / CASP12 / CASP4 / CASP5 / caspase 1 / Caspase-12 / caspase 12 (gene/pseudogene) / Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10 / caspase 4 / Caspase-4 Caspase-4 subunit p10 Caspase-4 subunit p20 / caspase 5 / O08736 / P29452 / P29466 / P49662 / P51878 / P70343 / Q6UXS9
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 41993551
Gene end: 42004544
  
Corresponding Affymetrix probe sets: Dr.1168.1.S1_at (Zebrafish Array)   NM_131505_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000034228
NCBI entrez gene - 57933     See in Manteia.
RefSeq - NM_131505
RefSeq Peptide - NP_571580
swissprot - Q9I9L7
ZFIN ID - ZDB-GENE-000616-3
Ensembl - ENSDARG00000008165
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000001049Gallus gallus
 CASP1ENSG00000137752Homo sapiens
 CASP12ENSG00000204403Homo sapiens
 CASP4ENSG00000196954Homo sapiens
 CASP5ENSG00000137757Homo sapiens
 Casp1ENSMUSG00000025888Mus musculus
 Casp12ENSMUSG00000025887Mus musculus
 Casp4ENSMUSG00000033538Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
zgc:171731 / CASP5* / CASP1* / CASP4* / CASP12* / O08736* / P29452* / P29466* / P49662* / P51878* / P70343* / Q6UXS9* / caspase 1* / caspase 4* / caspase 5* / Caspase-12 * / caspase 12 (gen...ENSDARG0000001465738
caspb / caspase b / CASP4* / CASP5* / CASP1* / Q6UXS9* / CASP12* / O08736* / P29452* / P29466* / P49662* / P51878* / P70343* / caspase 5* / caspase 4* / caspase 1* / Caspase-12 * / caspase ...ENSDARG0000005203935
caspbl / caspase b, like / CASP4* / CASP5* / CASP1* / Q6UXS9* / CASP12* / O08736* / P29452* / P29466* / P49662* / P51878* / P70343* / caspase 5* / caspase 4* / caspase 1* / Caspase-12 * / c...ENSDARG0000009443334


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR004020  DAPIN domain
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0050727 regulation of inflammatory response IBA
 cellular_componentGO:0072557 IPAF inflammasome complex IBA
 cellular_componentGO:0072559 NLRP3 inflammasome complex IBA
 cellular_componentGO:0097169 AIM2 inflammasome complex IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0032090 Pyrin domain binding IPI
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IBA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
Interleukin-1 processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism viability , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased thickness , abnormal
Meckels cartilage deformed , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage decreased thickness , abnormal
palatoquadrate cartilage deformed , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage inverted , abnormal
ceratohyal cartilage deformed , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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