ENSDARG00000008434


Danio rerio

Features
Gene ID: ENSDARG00000008434
  
Biological name :bcl2l1
  
Synonyms : bcl2l1 / bcl2-like 1
  
Possible biological names infered from orthology : Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA. / Q07817 / Q64373
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 18953870
Gene end: 18982499
  
Corresponding Affymetrix probe sets: Dr.11508.2.S1_a_at (Zebrafish Array)   Dr.11508.4.S1_a_at (Zebrafish Array)   NM_131807_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000027919
Ensembl peptide - ENSDARP00000119990
NCBI entrez gene - 114401     See in Manteia.
RefSeq - NM_131807
RefSeq Peptide - NP_571882
swissprot - Q90Z98
ZFIN ID - ZDB-GENE-010730-1
Ensembl - ENSDARG00000008434
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BCL2L1ENSGALG00000006211Gallus gallus
 BCL2L1ENSG00000171552Homo sapiens
 Bcl2l1ENSMUSG00000007659Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
bcl2a / BCL2, apoptosis regulator a / BCL2* / P10417* / P10415* / BCL2, apoptosis regulator* / Apoptosis regulator Bcl-2 *ENSDARG0000009470431
bcl2b / BCL2, apoptosis regulator b / BCL2* / P10417* / P10415* / BCL2, apoptosis regulator* / Apoptosis regulator Bcl-2 *ENSDARG0000008910928


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR003093  Apoptosis regulator, Bcl-2 protein, BH4
 IPR013279  Apoptosis regulator, Bcl-X
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR026298  Blc2 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001894 tissue homeostasis IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA
 biological_processGO:0030878 thyroid gland development IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IBA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
 molecular_functionGO:0046982 protein heterodimerization activity IBA


Pathways (from Reactome)
Pathway description
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
The NLRP1 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system hypoplastic , abnormal
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 ZFA:0001072 thyroid follicle thyroid follicle hypoplastic , abnormal
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 ZFA:0001094 whole organism whole organism lacks all parts of type extension , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000054937 badb / BCL2 associated agonist of cell death b / BAD* / Q61337* / Q92934* / BCL2 associated agonist of cell death*  / complex / reaction
 ENSDARG00000087993 bada / BCL2 associated agonist of cell death a / BAD* / Q92934* / BCL2 associated agonist of cell death*  / complex / reaction






 

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