ENSDARG00000008986


Danio rerio

Features
Gene ID: ENSDARG00000008986
  
Biological name :e2f7
  
Synonyms : e2f7 / E2F transcription factor 7 / Q5RIX9
  
Possible biological names infered from orthology : Mus musculus E2F transcription factor 7 (E2f7), transcript variant 2, mRNA. / Q6S7F2 / Q96AV8
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 2530841
Gene end: 2545345
  
Corresponding Affymetrix probe sets: Dr.15595.2.S1_at (Zebrafish Array)   Dr.21523.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000117568
Ensembl peptide - ENSDARP00000125355
NCBI entrez gene - 567941     See in Manteia.
RefSeq - NM_001045147
RefSeq Peptide - NP_001038612
swissprot - H0WES7
swissprot - Q5RIX9
ZFIN ID - ZDB-GENE-030131-3527
Ensembl - ENSDARG00000008986
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E2F7ENSGALG00000031340Gallus gallus
 E2F7ENSG00000165891Homo sapiens
 E2f7ENSMUSG00000020185Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
e2f8 / F1QZ88 / E2F transcription factor 8 / A0AVK6* / Q58FA4* / Transcription factor E2F8 *ENSDARG0000005732330


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR015633  E2F Family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001946 lymphangiogenesis IGI
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008045 motor neuron axon guidance IGI
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator ISS
 biological_processGO:0032466 negative regulation of cytokinesis ISS
 biological_processGO:0032877 positive regulation of DNA endoreduplication ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0060718 chorionic trophoblast cell differentiation ISS
 biological_processGO:0070365 hepatocyte differentiation ISS
 biological_processGO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle ISS
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0001047 core promoter binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity ISS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001061 intersegmental artery intersegmental artery malformed , abnormal
intersegmental artery branching involved in blood vessel morphogenesis decreased process quality , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel hypoplastic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000057323 e2f8 / F1QZ88 / E2F transcription factor 8 / A0AVK6* / Q58FA4* / Transcription factor E2F8 *  / complex / reaction
 ENSDARG00000008986 e2f7 / Q5RIX9 / E2F transcription factor 7 / Q96AV8* / Q6S7F2* / Mus musculus E2F transcription factor 7 (E2f7), transcript variant 2, mRNA.*  / complex / reaction






 

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