ENSDARG00000010758


Danio rerio

Features
Gene ID: ENSDARG00000010758
  
Biological name :capn12
  
Synonyms : calpain 12 / capn12
  
Possible biological names infered from orthology : Q6ZSI9
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 36664654
Gene end: 36729637
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000089743
Ensembl peptide - ENSDARP00000106290
NCBI entrez gene - 799247     See in Manteia.
RefSeq - NM_001083063
RefSeq - XM_005173670
RefSeq Peptide - NP_001076532
swissprot - Q1LUX4
swissprot - F1QL66
ZFIN ID - ZDB-GENE-050419-245
Ensembl - ENSDARG00000010758
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CAPN12ENSG00000182472Homo sapiens
 Capn12ENSMUSG00000054083Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
capn3a / calpain 3a, (p94) / CAPN3* / P20807* / calpain 3*ENSDARG0000004186438
zgc:92480 / CAPN2* / P17655* / calpain 2*ENSDARG0000003421137
capn1a / calpain 1, (mu/I) large subunit a / CAPN11* / Q6J756* / Q9UMQ6* / calpain 11*ENSDARG0000005270237
CAPN1 / si:dkeyp-50d11.2 / O35350* / P07384* / calpain 1* / Calpain-1 catalytic subunit *ENSDARG0000005533837
capn8 / calpain 8 / A6NHC0*ENSDARG0000005571537
capn1b / calpain 1, (mu/I) large subunit b / CAPN11* / Q6J756* / Q9UMQ6* / calpain 11*ENSDARG0000005274836
zgc:55262 / CAPN1* / O35350* / P07384* / calpain 1* / Calpain-1 catalytic subunit *ENSDARG0000004519935
capn2b / calpain 2, (m/II) large subunit b / CAPN2* / P17655* / O08529* / calpain 2* / Calpain-2 catalytic subunit *ENSDARG0000005559235
capn2a / calpain 2, (m/II) large subunit a / CAPN2* / P17655* / O08529* / calpain 2* / Calpain-2 catalytic subunit *ENSDARG0000009169935
capn9 / calpain 9 / O14815* / Q9D805*ENSDARG0000001234134
capn3b / calpain 3b / CAPN3* / P20807* / Q64691* / calpain 3*ENSDARG0000004303534
si:ch211-202f3.3 / A8MX76* / CAPN14* / CAPN13* / Q3UW68* / Q6MZZ7* / calpain 14* / calpain 13*ENSDARG0000005291730
zgc:136872 / A8MX76* / CAPN14* / CAPN13* / Q3UW68* / Q6MZZ7* / calpain 14* / calpain 13*ENSDARG0000000855329
zgc:85932ENSDARG0000009823928
capn5b / calpain 5b / CAPN5* / O08688* / O15484* / calpain 5*ENSDARG0000006974827
si:dkey-19b23.13ENSDARG0000006185026
capn5a / calpain 5a / CAPN5* / O08688* / O15484* / calpain 5*ENSDARG0000010331726
zgc:162184 / A8MX76* / CAPN14* / CAPN13* / Q3UW68* / Q6MZZ7* / calpain 14* / calpain 13*ENSDARG0000007721725
si:ch211-202f3.4 / A8MX76* / CAPN14* / CAPN13* / Q3UW68* / Q6MZZ7* / calpain 14* / calpain 13*ENSDARG0000009172324


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR001300  Peptidase C2, calpain, catalytic domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR022682  Peptidase C2, calpain, large subunit, domain III
 IPR022683  Peptidase C2, calpain, domain III
 IPR022684  Peptidase C2, calpain family
 IPR033883  Calpain subdomain III


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0030216 keratinocyte differentiation IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism decreased life span , abnormal
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 ZFA:0001117 post-vent region post-vent region curved , abnormal
Show

 ZFA:0001179 epidermal superficial stratum epidermal superficial stratum morphology , abnormal
Show

 ZFA:0009158 keratinocyte keratinocyte increased size , abnormal
keratinocyte actin filament bundle decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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