ENSDARG00000052702


Danio rerio

Features
Gene ID: ENSDARG00000052702
  
Biological name :capn1a
  
Synonyms : calpain 1, (mu/I) large subunit a / capn1a
  
Possible biological names infered from orthology : calpain 11 / CAPN11 / Q6J756 / Q9UMQ6
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 42679767
Gene end: 42724645
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000046065
Ensembl peptide - ENSDARP00000130846
NCBI entrez gene - 393417     See in Manteia.
RefSeq - NM_200445
RefSeq Peptide - NP_956739
swissprot - B8A6G0
swissprot - A0A0R4ID08
ZFIN ID - ZDB-GENE-040426-1263
Ensembl - ENSDARG00000052702
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CAPN11ENSGALG00000010186Gallus gallus
 CAPN11ENSG00000137225Homo sapiens
 Capn11ENSMUSG00000058626Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
capn1b / calpain 1, (mu/I) large subunit b / CAPN11* / Q6J756* / Q9UMQ6* / calpain 11*ENSDARG0000005274879
zgc:55262 / CAPN1* / O35350* / P07384* / calpain 1* / Calpain-1 catalytic subunit *ENSDARG0000004519966
CAPN1 / si:dkeyp-50d11.2 / O35350* / P07384* / calpain 1* / Calpain-1 catalytic subunit *ENSDARG0000005533866
zgc:92480 / CAPN2* / P17655* / calpain 2*ENSDARG0000003421164
capn2a / calpain 2, (m/II) large subunit a / CAPN2* / P17655* / O08529* / calpain 2* / Calpain-2 catalytic subunit *ENSDARG0000009169962
capn2b / calpain 2, (m/II) large subunit b / CAPN2* / P17655* / O08529* / calpain 2* / Calpain-2 catalytic subunit *ENSDARG0000005559261
capn8 / calpain 8 / A6NHC0*ENSDARG0000005571560
capn3a / calpain 3a, (p94) / CAPN3* / P20807* / calpain 3*ENSDARG0000004186454
capn9 / calpain 9 / O14815* / Q9D805*ENSDARG0000001234153
capn3b / calpain 3b / CAPN3* / P20807* / Q64691* / calpain 3*ENSDARG0000004303550
capn12 / calpain 12 / Q6ZSI9*ENSDARG0000001075838
si:ch211-202f3.3 / A8MX76* / CAPN14* / CAPN13* / Q3UW68* / Q6MZZ7* / calpain 14* / calpain 13*ENSDARG0000005291737
zgc:136872 / A8MX76* / CAPN14* / CAPN13* / Q3UW68* / Q6MZZ7* / calpain 14* / calpain 13*ENSDARG0000000855336
zgc:85932ENSDARG0000009823936
capn5b / calpain 5b / CAPN5* / O08688* / O15484* / calpain 5*ENSDARG0000006974833
capn5a / calpain 5a / CAPN5* / O08688* / O15484* / calpain 5*ENSDARG0000010331733
si:dkey-19b23.13ENSDARG0000006185031
zgc:162184 / A8MX76* / CAPN14* / CAPN13* / Q3UW68* / Q6MZZ7* / calpain 14* / calpain 13*ENSDARG0000007721729
si:ch211-202f3.4 / A8MX76* / CAPN14* / CAPN13* / Q3UW68* / Q6MZZ7* / calpain 14* / calpain 13*ENSDARG0000009172328


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR001300  Peptidase C2, calpain, catalytic domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR022682  Peptidase C2, calpain, large subunit, domain III
 IPR022683  Peptidase C2, calpain, domain III
 IPR022684  Peptidase C2, calpain family
 IPR033883  Calpain subdomain III


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0021785 branchiomotor neuron axon guidance IMP
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
brain microtubule cytoskeleton disorganized , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000075 spinal cord spinal cord motor neuron disorganized , abnormal
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 ZFA:0000076 swim bladder swim bladder aplastic , abnormal
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 ZFA:0000106 extension extension physical object quality , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000206 facial nerve motor nucleus facial nerve motor nucleus neuronal cell body mislocalised , abnormal
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 ZFA:0000387 motor nucleus of vagal nerve motor nucleus of vagal nerve mislocalised , abnormal
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 ZFA:0001365 trigeminal motor nucleus trigeminal motor nucleus mislocalised , abnormal
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 ZFA:0005731 branchiomotor neuron branchiomotor neuron disorganized , abnormal
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 ZFA:0009052 motor neuron motor neuron axon disorganized , abnormal
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 ZFA:0009248 neuron neuron microtubule cytoskeleton disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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