ENSDARG00000012881


Danio rerio

Features
Gene ID: ENSDARG00000012881
  
Biological name :slc4a1a
  
Synonyms : slc4a1a / solute carrier family 4 (anion exchanger), member 1a (Diego blood group)
  
Possible biological names infered from orthology : P02730 / P04919 / SLC4A1 / solute carrier family 4 (anion exchanger), member 1 / solute carrier family 4 member 1 (Diego blood group)
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 20065861
Gene end: 20092124
  
Corresponding Affymetrix probe sets: Dr.20971.1.S2_at (Zebrafish Array)   NM_198338_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000005654
Ensembl peptide - ENSDARP00000032458
Ensembl peptide - ENSDARP00000110238
NCBI entrez gene - 84703     See in Manteia.
RefSeq - NM_198338
RefSeq Peptide - NP_938152
swissprot - Q7ZZJ7
ZFIN ID - ZDB-GENE-010525-1
Ensembl - ENSDARG00000012881
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P02730ENSG00000004939Homo sapiens
 P04919ENSMUSG00000006574Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
slc4a1b / solute carrier family 4 (anion exchanger), member 1b (Diego blood group) / P04919* / SLC4A1* / P02730* / solute carrier family 4 (anion exchanger), member 1* / solute carrier fami...ENSDARG0000002456060
slc4a2b / solute carrier family 4 (anion exchanger), member 2b / SLC4A2* / P04920* / solute carrier family 4 member 2* / solute carrier family 4 (anion exchanger), member 2*ENSDARG0000005233050
slc4a2a / solute carrier family 4 (anion exchanger), member 2a / SLC4A2* / P04920* / solute carrier family 4 member 2* / solute carrier family 4 (anion exchanger), member 2*ENSDARG0000002817349
slc4a3 / solute carrier family 4 (anion exchanger), member 3 / P48751* / solute carrier family 4 member 3*ENSDARG0000010400543
si:ch211-48m9.1 / Q9BY07* / SLC4A5* / solute carrier family 4 member 5*ENSDARG0000000277133
slc4a4b / solute carrier family 4 (sodium bicarbonate cotransporter), member 4b / Q9Y6R1* / SLC4A4* / O88343* / solute carrier family 4 member 4* / solute carrier family 4 (anion exchanger)...ENSDARG0000004480833
slc4a5 / si:ch211-48m9.1 / solute carrier family 4 (sodium bicarbonate cotransporter), member 5 / Q9BY07* / solute carrier family 4 member 5*ENSDARG0000010438733
slc4a4a / solute carrier family 4 (sodium bicarbonate cotransporter), member 4a / Q9Y6R1* / SLC4A4* / O88343* / solute carrier family 4 member 4* / solute carrier family 4 (anion exchanger)...ENSDARG0000001373032
slc4a8 / solute carrier family 4, sodium bicarbonate cotransporter, member 8 / Q8JZR6* / Q2Y0W8* / solute carrier family 4 member 8* / solute carrier family 4 (anion exchanger), member 8*ENSDARG0000001553132
slc4a10a / solute carrier family 4, sodium bicarbonate transporter, member 10a / Q6U841* / Q5DTL9* / SLC4A10* / solute carrier family 4 member 10* / solute carrier family 4, sodium bicarbon...ENSDARG0000006313332
slc4a7 / solute carrier family 4, sodium bicarbonate cotransporter, member 7 / Q9Y6M7* / solute carrier family 4 member 7*ENSDARG0000007395232
slc4a10b / solute carrier family 4, sodium bicarbonate transporter, member 10b / Q6U841* / Q5DTL9* / SLC4A10* / solute carrier family 4 member 10* / solute carrier family 4, sodium bicarbon...ENSDARG0000006030330
slc4a11 / solute carrier family 4, sodium borate transporter, member 11 / Q8NBS3* / A2AJN7* / solute carrier family 4 member 11* / Sodium bicarbonate transporter-like protein 11 *ENSDARG0000007553220


Protein motifs (from Interpro)
Interpro ID Name
 IPR001717  Anion exchange protein
 IPR003020  Bicarbonate transporter, eukaryotic
 IPR011531  Bicarbonate transporter, C-terminal
 IPR013769  Band 3 cytoplasmic domain
 IPR016152  Phosphotransferase/anion transporter
 IPR018241  Anion exchange, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006820 anion transport IDA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0015701 bicarbonate transport IEA
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0098656 anion transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005452 inorganic anion exchanger activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008509 anion transmembrane transporter activity IEA
 molecular_functionGO:0008510 sodium:bicarbonate symporter activity IBA


Pathways (from Reactome)
Pathway description
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Bicarbonate transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood quality , abnormal
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 ZFA:0000009 cardiac ventricle cardiac ventricle cardiac muscle cell increased amount , abnormal
cardiac ventricle cardiac muscle cell decreased amount , abnormal
cardiac ventricle increased size , abnormal
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 ZFA:0000114 heart heart increased size , abnormal
heart decreased functionality , abnormal
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 ZFA:0000173 bulbus arteriosus bulbus arteriosus increased size , abnormal
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 ZFA:0000471 atrium atrium increased size , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism dead , abnormal
whole organism decreased life span , abnormal
whole organism life span , ameliorated
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte increased size , abnormal
nucleate erythrocyte decreased amount , abnormal
nucleate erythrocyte basophilic , abnormal
nucleate erythrocyte hemoglobin complex decreased amount , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased size , abnormal
cardiac muscle cell hyperplastic , abnormal
cardiac muscle cell hypertrophic , abnormal
cardiac muscle cell increased size , abnormal
cardiac muscle cell myofibril disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000012881 slc4a1a / solute carrier family 4 (anion exchanger), member 1a (Diego blood group) / P04919* / SLC4A1* / P02730* / solute carrier family 4 (anion exchanger), member 1* / solute carrier fami...  / complex
 ENSDARG00000024560 slc4a1b / solute carrier family 4 (anion exchanger), member 1b (Diego blood group) / P04919* / SLC4A1* / P02730* / solute carrier family 4 (anion exchanger), member 1* / solute carrier fami...  / complex






 

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