ENSDARG00000014634


Danio rerio

Features
Gene ID: ENSDARG00000014634
  
Biological name :mbtps1
  
Synonyms : mbtps1 / membrane-bound transcription factor peptidase, site 1
  
Possible biological names infered from orthology : Membrane-bound transcription factor site-1 protease / Q14703 / Q9WTZ2
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 21645309
Gene end: 21685055
  
Corresponding Affymetrix probe sets: Dr.7917.1.A1_at (Zebrafish Array)   NM_199213_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000007839
NCBI entrez gene - 326710     See in Manteia.
RefSeq - XM_021467593
RefSeq - NM_199213
RefSeq Peptide - NP_954683
swissprot - Q1LWH3
ZFIN ID - ZDB-GENE-030131-4909
Ensembl - ENSDARG00000014634
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MBTPS1ENSGALG00000003293Gallus gallus
 MBTPS1ENSG00000140943Homo sapiens
 Mbtps1ENSMUSG00000031835Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR029062  Class I glutamine amidotransferase-like
 IPR034185  Site-1 peptidase catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0051216 cartilage development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004175 endopeptidase activity ISS
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)
ATF6 (ATF6-alpha) activates chaperones
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
CREB3 factors activate genes
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
Show

 ZFA:0000123 liver liver circular , abnormal
liver cell fatty , abnormal
liver cell fatty , ameliorated
Show

 ZFA:0001114 head head decreased size , abnormal
head cuboid , abnormal
Show

 ZFA:0001115 trunk trunk curved dorsal , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
mandibular arch skeleton decreased length , abnormal
Show

 ZFA:0001501 cartilage element cartilage element collagen type II trimer aggregated , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 increased size , abnormal
pharyngeal arch 3-7 chondrocyte disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000012656 atf6 / activating transcription factor 6 / F6VAN0* / P18850* / Cyclic AMP-dependent transcription factor ATF-6 alpha Processed cyclic AMP-dependent transcription factor ATF-6 alpha*  / reaction
 ENSDARG00000090903 creb3l3b / cAMP responsive element binding protein 3-like 3b / Q68CJ9* / Q91XE9* / CREB3L3* / cAMP responsive element binding protein 3 like 3* / Cyclic AMP-responsive element-binding prote...  / reaction
 ENSDARG00000018096 scap / SREBF chaperone / Q12770* / Q6GQT6*  / reaction






 

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