Manteia

ENSDARG00000019307

Danio rerio

Features

Gene ID:	ENSDARG00000019307

Biological name :	dusp5

Synonyms :	dual specificity phosphatase 5 / dusp5

Possible biological names infered from orthology :	Q16690

Species:	Danio rerio

Chr. number:	22
Strand:	-1
Band:
Gene start:	29911326
Gene end:	29922872

Corresponding Affymetrix probe sets:	Dr.5365.1.A1_at (Zebrafish Array)

Cross references:	Ensembl peptide - ENSDARP00000005408 NCBI entrez gene - 114436 See in Manteia. RefSeq - NM_212565 RefSeq Peptide - NP_997730 swissprot - Q6PBT4 ZFIN ID - ZDB-GENE-010625-1 Ensembl - ENSDARG00000019307

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
DUSP5	ENSGALG00000032618	Gallus gallus
DUSP5	ENSG00000138166	Homo sapiens
Dusp5	ENSMUSG00000034765	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
dusp1 / dual specificity phosphatase 1 / P28562* / P28563* / Dual specificity protein phosphatase 1 *	ENSDARG00000100515	45
dusp4 / dual specificity phosphatase 4 / Q13115* / Q8BFV3* / Dual specificity protein phosphatase 4 *	ENSDARG00000044688	42
dusp2 / dual specificity phosphatase 2 / Q05923*	ENSDARG00000098108	38
dusp7 / dual specificity phosphatase 7 / Q16829*	ENSDARG00000101413	27
dusp8a / dual specificity phosphatase 8a / DUSP8* / Q13202* / O09112* / dual specificity phosphatase 8* / Dual specificity protein phosphatase 8 *	ENSDARG00000009299	26
dusp6 / dual specificity phosphatase 6 / Q16828* / Q9DBB1* / Dual specificity protein phosphatase 6 *	ENSDARG00000070914	26
dusp10 / dual specificity phosphatase 10 / Q9ESS0* / Q9Y6W6* / Dual specificity protein phosphatase 10 *	ENSDARG00000052465	25
dusp16 / dual specificity phosphatase 16 / Q9BY84*	ENSDARG00000102474	25
ssh2b / slingshot protein phosphatase 2b / SSH2* / Q5SW75* / Q76I76* / slingshot protein phosphatase 2* / Protein phosphatase Slingshot homolog 2 *	ENSDARG00000098955	22
si:dkey-175m17.7	ENSDARG00000078317	21
ssh2a / slingshot protein phosphatase 2a / SSH2* / Q5SW75* / Q76I76* / slingshot protein phosphatase 2* / Protein phosphatase Slingshot homolog 2 *	ENSDARG00000088440	21
ssh1a / slingshot protein phosphatase 1a / SSH1* / Q76I79* / Q8WYL5* / slingshot protein phosphatase 1* / Protein phosphatase Slingshot homolog 1 *	ENSDARG00000056780	20
ssh1b / slingshot protein phosphatase 1b / SSH1* / Q76I79* / Q8WYL5* / slingshot protein phosphatase 1* / Protein phosphatase Slingshot homolog 1 *	ENSDARG00000010031	18
si:ch211-203d1.3 / SSH3* / Q8TE77* / Q8K330* / slingshot protein phosphatase 3* / Mus musculus slingshot protein phosphatase 3 (Ssh3), transcript variant 2, mRNA.*	ENSDARG00000079591	18
si:ch211-195b15.8	ENSDARG00000094836	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR000340	Dual specificity phosphatase, catalytic domain
IPR000387	Tyrosine specific protein phosphatases domain
IPR001763	Rhodanese-like domain
IPR003595	Protein-tyrosine phosphatase, catalytic
IPR008343	Mitogen-activated protein (MAP) kinase phosphatase
IPR016130	Protein-tyrosine phosphatase, active site
IPR020422	Dual specificity protein phosphatase domain
IPR024950	Dual specificity phosphatase
IPR029021	Protein-tyrosine phosphatase-like

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000188	inactivation of MAPK activity	IEA
biological_process	GO:0001706	endoderm formation	IBA
biological_process	GO:0006470	protein dephosphorylation	IEA
biological_process	GO:0016311	dephosphorylation	IEA
biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	IEA
molecular_function	GO:0004721	phosphoprotein phosphatase activity	IEA
molecular_function	GO:0004725	protein tyrosine phosphatase activity	IEA
molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0016791	phosphatase activity	IEA
molecular_function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	IEA

Pathways (from Reactome)

Pathway description

RAF-independent MAPK1/3 activation

Negative regulation of MAPK pathway

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000027552	mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*	/ reaction
ENSDARG00000070573	mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr