ENSDARG00000020008


Danio rerio

Features
Gene ID: ENSDARG00000020008
  
Biological name :vcp
  
Synonyms : Q7ZU99 / valosin containing protein / vcp
  
Possible biological names infered from orthology : P55072 / Q01853
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 41510387
Gene end: 41520980
  
Corresponding Affymetrix probe sets: Dr.25189.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000012048
NCBI entrez gene - 327197     See in Manteia.
swissprot - Q7ZU99
ZFIN ID - ZDB-GENE-030131-5408
Ensembl - ENSDARG00000020008
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VCPENSGALG00000001986Gallus gallus
 VCPENSG00000165280Homo sapiens
 VcpENSMUSG00000028452Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
zgc:136908ENSDARG0000001198385


Protein motifs (from Interpro)
Interpro ID Name
 IPR003338  CDC48, N-terminal subdomain
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR004201  CDC48, domain 2
 IPR005938  AAA ATPase, CDC48 family
 IPR009010  Aspartate decarboxylase-like domain superfamily
 IPR015415  Vps4 oligomerisation, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029067  CDC48 domain 2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair ISS
 biological_processGO:0006914 autophagy ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0016236 macroautophagy ISS
 biological_processGO:0016567 protein ubiquitination ISS
 biological_processGO:0018279 protein N-linked glycosylation via asparagine ISS
 biological_processGO:0019985 translesion synthesis ISS
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway ISS
 biological_processGO:0032510 endosome to lysosome transport via multivesicular body sorting pathway ISS
 biological_processGO:0036503 ERAD pathway ISS
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0097352 autophagosome maturation ISS
 biological_processGO:2000058 regulation of ubiquitin-dependent protein catabolic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0035861 site of double-strand break ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISS


Pathways (from Reactome)
Pathway description
Translesion Synthesis by POLH
HSF1 activation
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Hedgehog ligand biogenesis
Josephin domain DUBs
Ovarian tumor domain proteases
Neutrophil degranulation
Protein methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic , abnormal
brain degeneration , abnormal
Show

 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer neuron degenerate , abnormal
retinal ganglion cell layer decayed , abnormal
Show

 ZFA:0000101 diencephalon diencephalon nucleus aggregated , abnormal
diencephalon apoptotic , abnormal
diencephalon cell decreased amount , abnormal
Show

 ZFA:0000107 eye eye apoptotic , abnormal
eye nucleus aggregated , abnormal
eye size , abnormal
eye degeneration , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II decreased width , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased mobility , abnormal
Show

 ZFA:0001114 head head size , abnormal
Show

 ZFA:0001115 trunk trunk curved ventral , abnormal
Show

 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer neuron degenerate , abnormal
retinal inner plexiform layer decayed , abnormal
Show

 ZFA:0009052 motor neuron motor neuron axon branched , abnormal
motor neuron axon truncated , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004581 sel1l / sel-1 suppressor of lin-12-like (C. elegans) / Q9UBV2* / Q9Z2G6* / SEL1L ERAD E3 ligase adaptor subunit*  / complex
 ENSDARG00000020008 vcp / Q7ZU99 / valosin containing protein / P55072* / Q01853*  / complex
 ENSDARG00000008542 yod1 / Q567B1 / YOD1 deubiquitinase / Q5VVQ6* / Q8CB27*  / complex / reaction
 ENSDARG00000010051 ufd1l / ubiquitin recognition factor in ER associated degradation 1 / UFD1* / P70362* / Q92890*  / complex
 ENSDARG00000008384 hdac6 / histone deacetylase 6 / Q9UBN7* / Q9Z2V5*  / complex
 ENSDARG00000100487 nploc4 / NPL4 homolog, ubiquitin recognition factor / Q8TAT6*  / complex
 ENSDARG00000099274 atxn3 / ataxin 3 / ATXN3L* / Q9H3M9* / P54252* / ataxin 3 like*  / complex / reaction
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSDARG00000042401 derl2 / derlin 2 / Q9GZP9*  / complex
 ENSDARG00000070231 polh / polymerase (DNA directed), eta / Q9JJN0* / Q9Y253* / DNA polymerase eta*  / complex / reaction
 ENSDARG00000060021 vcpkmt / valosin containing protein lysine (K) methyltransferase / Q8C436* / Q9H867* / valosin containing protein lysine methyltransferase*  / reaction
 ENSDARG00000017842 syvn1 / synovial apoptosis inhibitor 1, synoviolin / Q86TM6* / synoviolin 1*  / complex
 ENSDARG00000104709 sprtn / SprT-like N-terminal domain / Q9H040*  / complex / reaction






 

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