ENSDARG00000021232


Danio rerio

Features
Gene ID: ENSDARG00000021232
  
Biological name :nkx2.7
  
Synonyms : NK2 transcription factor related 7 / nkx2.7
  
Possible biological names infered from orthology : A6NCS4 / Homeobox protein Nkx-2.3 / Homeobox protein Nkx-2.5 / Homeobox protein Nkx-2.6 / NK2 homeobox 3 / NK2 homeobox 5 / NK2 homeobox 6 / NKX2-3 / NKX2-5 / NKX2-6 / P42582 / P43688 / P52952 / P97334 / Q8TAU0
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 50284859
Gene end: 50287949
  
Corresponding Affymetrix probe sets: Dr.272.1.S1_at (Zebrafish Array)   NM_131419_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000004716
NCBI entrez gene - 30694     See in Manteia.
RefSeq - NM_131419
RefSeq Peptide - NP_571494
swissprot - Q98873
ZFIN ID - ZDB-GENE-990415-179
Ensembl - ENSDARG00000021232
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NKX2-6ENSGALG00000000365Gallus gallus
 A6NCS4ENSG00000180053Homo sapiens
 NKX2-3ENSG00000119919Homo sapiens
 NKX2-5ENSG00000183072Homo sapiens
 Nkx2-3ENSMUSG00000044220Mus musculus
 Nkx2-5ENSMUSG00000015579Mus musculus
 Nkx2-6ENSMUSG00000044186Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nkx2.3 / NK2 homeobox 3 / Q8TAU0* / P42582* / P43688* / P52952* / P97334* / A6NCS4* / NKX2-5* / NKX2-6* / NK2 homeobox 5* / NK2 homeobox 6* / Homeobox protein Nkx-2.6 * / Homeobox protein N...ENSDARG0000003909551
nkx2.5 / NK2 homeobox 5 / Q8TAU0* / P42582* / P43688* / P52952* / P97334* / A6NCS4* / NKX2-3* / NKX2-6* / NK2 homeobox 3* / NK2 homeobox 6* / Homeobox protein Nkx-2.6 * / Homeobox protein N...ENSDARG0000001800445
Q90481 / nkx2.2a / NK2 homeobox 2a / NKX2-2* / O95096* / NK2 homeobox 2*ENSDARG0000005329835
nkx2.4a / NK2 homeobox 4aENSDARG0000007510734
nkx2.1 / NK2 homeobox 1 / Q9H2Z4* / P43699* / P50220* / Q9EQM3* / NKX2-4* / NK2 homeobox 4* / Homeobox protein Nkx-2.1 * / Homeobox protein Nkx-2.4 *ENSDARG0000001983532
nkx2.4b / NK2 homeobox 4bENSDARG0000010410732
nkx3.3 / NK3 homeobox 3ENSDARG0000006932727
nkx2.2b / NK2 homeobox 2bENSDARG0000010154927
nkx3.2 / NK3 homeobox 2 / P78367*ENSDARG0000003763926
hmx3a / H6 family homeobox 3a / HMX3* / P42581* / A6NHT5* / H6 family homeobox 3* / Homeobox protein HMX3 *ENSDARG0000007095523
hmx4 / H6 family homeobox 4ENSDARG0000000794120
nkx3-1 / NK3 homeobox 1 / P97436* / Q99801*ENSDARG0000007828020
hmx3b / H6 family homeobox 3bENSDARG0000009671620
hmx2 / H6 family homeobox 2 / A2RU54* / P43687* / Homeobox protein HMX2 *ENSDARG0000007095419
hmx1 / H6 family homeobox 1 / O70218* / Q9NP08* / Homeobox protein HMX1 *ENSDARG0000009565119


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007492 endoderm development TAS
 biological_processGO:0007498 mesoderm development TAS
 biological_processGO:0007507 heart development TAS
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0060038 cardiac muscle cell proliferation IGI
 biological_processGO:1901210 regulation of cardiac chamber formation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
cardiac ventricle decreased length , abnormal
cardiac ventricle increased width , abnormal
cardiac ventricle circular , abnormal
cardiac ventricle hypoplastic , abnormal
cardiac ventricle morphology , abnormal
cardiac ventricle hypotrophic , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000114 heart heart morphology , abnormal
heart decreased size , abnormal
Show

 ZFA:0000173 bulbus arteriosus bulbus arteriosus hypoplastic , abnormal
Show

 ZFA:0000360 heart tube heart tube morphology , abnormal
heart tube shape , abnormal
Show

 ZFA:0000471 atrium atrium shape , abnormal
atrium spherical , abnormal
atrium dilated , abnormal
atrium increased size , abnormal
atrium increased width , abnormal
atrium distended , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
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 ZFA:0001261 ventricular system ventricular system swollen , abnormal
Show

 ZFA:0001317 endocardial cushion endocardial cushion aplastic , abnormal
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 ZFA:0001374 atrial myocardium atrial myocardium increased size , abnormal
atrial myocardium distended , abnormal
atrial myocardium cardiac muscle cell loose , abnormal
atrial myocardium increased width , abnormal
atrial myocardium disorganized , abnormal
atrial myocardium swollen , abnormal
atrial myocardium cardiac muscle cell increased amount , abnormal
atrial myocardium dilated , abnormal
Show

 ZFA:0005061 ventricular myocardium ventricular myocardium decreased size , abnormal
ventricular myocardium increased width , abnormal
ventricular myocardium shortened , abnormal
ventricular myocardium cardiac muscle cell condensed , abnormal
ventricular myocardium hypoplastic , abnormal
ventricular myocardium decreased width , abnormal
ventricular myocardium cardiac muscle cell decreased amount , abnormal
ventricular myocardium decreased thickness , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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