ENSDARG00000023236


Danio rerio

Features
Gene ID: ENSDARG00000023236
  
Biological name :kcnh1a
  
Synonyms : kcnh1a / kcnh1b / potassium voltage-gated channel, subfamily H (eag-related), member 1a
  
Possible biological names infered from orthology : AC092017.3 / AL590132.1 / KCNH1 / O95259 / potassium voltage-gated channel subfamily H member 1
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 37902976
Gene end: 37952513
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000133869
NCBI entrez gene - 101154640     See in Manteia.
RefSeq - NM_001278814
RefSeq Peptide - NP_001265743
swissprot - F1RBP0
swissprot - A0A0R4IEI6
ZFIN ID - ZDB-GENE-061226-1
ZFIN ID - ZDB-GENE-121128-4
Ensembl - ENSDARG00000023236
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000009877Gallus gallus
 AC092017.3ENSG00000283952Homo sapiens
 AL590132.1ENSG00000284299Homo sapiens
 KCNH1ENSG00000143473Homo sapiens
 Kcnh1ENSMUSG00000058248Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kcnh1a / potassium voltage-gated channel, subfamily H (eag-related), member 1a / KCNH1* / O95259* / AC092017.3* / AL590132.1* / potassium voltage-gated channel subfamily H member 1*ENSDARG0000002416784
kcnh5b / potassium voltage-gated channel, subfamily H (eag-related), member 5bENSDARG0000006911771
kcnh5a / potassium voltage-gated channel, subfamily H (eag-related), member 5a / KCNH5* / Q8NCM2* / Q920E3* / potassium voltage-gated channel subfamily H member 5*ENSDARG0000004322070
kcnh2a / potassium voltage-gated channel, subfamily H (eag-related), member 2a / KCNH2* / Q12809* / potassium voltage-gated channel subfamily H member 2*ENSDARG0000002988133
kcnh6a / potassium voltage-gated channel, subfamily H (eag-related), member 6a / KCNH6* / KCNH7* / Q9NS40* / Q9ER47* / Q9H252* / potassium voltage-gated channel subfamily H member 6* / pota...ENSDARG0000000180332
kcnh4a / potassium voltage-gated channel, subfamily H (eag-related), member 4a / KCNH4* / Q9UQ05* / potassium voltage-gated channel subfamily H member 4*ENSDARG0000006256532
kcnh7 / potassium channel, voltage gated eag related subfamily H, member 7ENSDARG0000006268732
kcnh3 / potassium voltage-gated channel, subfamily H (eag-related), member 3 / Q9ULD8* / Q9WVJ0* / potassium voltage-gated channel subfamily H member 3*ENSDARG0000006956032
kcnh4b / potassium voltage-gated channel, subfamily H (eag-related), member 4b / KCNH4* / Q9UQ05* / potassium voltage-gated channel subfamily H member 4*ENSDARG0000006199031
kcnh8 / potassium voltage-gated channel, subfamily H (eag-related), member 8 / Q96L42* / potassium voltage-gated channel subfamily H member 8*ENSDARG0000006264030
kcnh6b / potassium voltage-gated channel, subfamily H (eag-related), member 6b / KCNH6* / KCNH7* / Q9NS40* / Q9ER47* / Q9H252* / potassium voltage-gated channel subfamily H member 6* / pota...ENSDARG0000001029625
CABZ01076968.1 / KCNH2* / Q12809* / potassium voltage-gated channel subfamily H member 2*ENSDARG0000010647324
cngk / cyclic nucleotide-gated potassium channelENSDARG0000009326718


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR001610  PAC motif
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR003949  Potassium channel, voltage-dependent, EAG
 IPR005821  Ion transport domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR030170  Potassium voltage-gated channel subfamily H member 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000160 phosphorelay signal transduction system IEA
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0021576 hindbrain formation IMP
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000155 phosphorelay sensor kinase activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IDA
 molecular_functionGO:0005267 potassium channel activity IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
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 ZFA:0000086 EVL EVL constricted , abnormal
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 ZFA:0000106 extension extension morphology , abnormal
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 ZFA:0000107 eye eye immature , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000823 rhombomere 5 rhombomere 5 decreased thickness , abnormal
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 ZFA:0000948 rhombomere 3 rhombomere 3 decreased thickness , abnormal
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 ZFA:0001094 whole organism whole organism dead , abnormal
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 ZFA:0001117 post-vent region post-vent region necrotic , abnormal
post-vent region kinked , abnormal
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 ZFA:0001462 somite border somite border inconspicuous , abnormal
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 ZFA:0009000 cell cell detached from post-vent region , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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