ENSDARG00000024933


Danio rerio

Features
Gene ID: ENSDARG00000024933
  
Biological name :spast
  
Synonyms : Q6NW58 / spast / spastin
  
Possible biological names infered from orthology : Q9QYY8 / Q9UBP0
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 51021279
Gene end: 51038885
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000029675
NCBI entrez gene - 405851     See in Manteia.
RefSeq - NM_212915
RefSeq Peptide - NP_998080
swissprot - Q6NW58
ZFIN ID - ZDB-GENE-040426-2331
Ensembl - ENSDARG00000024933
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPASTENSGALG00000010620Gallus gallus
 SPASTENSG00000021574Homo sapiens
 SpastENSMUSG00000024068Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fignl1 / fidgetin-like 1 / Q6PIW4* / Q8BPY9* / Fidgetin-like protein 1 *ENSDARG0000001642731
fign / fidgetin / Q5HY92* / fidgetin, microtubule severing factor*ENSDARG0000000866225
iqca1 / IQ motif containing with AAA domain 1 / Iqca* / Q86XH1* / Q9CUL5* / IQ and AAA domain-containing protein 1 *ENSDARG000000572764
si:dkey-157g16.6 / A6NMB9* / FIGNL2* / fidgetin like 2*ENSDARG000000570622
zgc:153738ENSDARG000000692302


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR007330  MIT
 IPR015415  Vps4 oligomerisation, C-terminal
 IPR017179  Spastin
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035106  Spastin, chordate


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IMP
 biological_processGO:0000281 mitotic cytokinesis ISS
 biological_processGO:0001578 microtubule bundle formation ISS
 biological_processGO:0007032 endosome organization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0008089 anterograde axonal transport ISS
 biological_processGO:0010458 exit from mitosis ISS
 biological_processGO:0019896 axonal transport of mitochondrion ISS
 biological_processGO:0021955 central nervous system neuron axonogenesis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031117 positive regulation of microtubule depolymerization IMP
 biological_processGO:0031122 cytoplasmic microtubule organization IMP
 biological_processGO:0031468 nuclear envelope reassembly ISS
 biological_processGO:0034214 protein hexamerization ISS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045773 positive regulation of axon extension IMP
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0051013 microtubule severing ISS
 biological_processGO:0051228 mitotic spindle disassembly ISS
 biological_processGO:0051260 protein homooligomerization ISS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IMP
 biological_processGO:0090148 membrane fission ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody ISS
 cellular_componentGO:0031965 nuclear membrane ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding ISS
 molecular_functionGO:0008568 microtubule-severing ATPase activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IBA
 molecular_functionGO:0043014 alpha-tubulin binding ISS
 molecular_functionGO:0048487 beta-tubulin binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord motor neuron truncated , abnormal
spinal cord motor neuron branchiness , abnormal
spinal cord microtubule cytoskeleton organization disrupted , abnormal
spinal cord microtubule cytoskeleton organization disrupted , ameliorated
spinal cord microtubule cytoskeleton disorganized , abnormal
spinal cord microtubule cytoskeleton disorganized , ameliorated
Show

 ZFA:0000106 extension extension morphology , abnormal
extension morphology , ameliorated
Show

 ZFA:0001058 caudal fin caudal fin morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism increased curvature , abnormal
whole organism decreased mobility , abnormal
whole organism arched , abnormal
whole organism arched , ameliorated
Show

 ZFA:0001114 head head morphology , abnormal
head hydrocephalic , abnormal
head hydrocephalic , ameliorated
Show

 ZFA:0009052 motor neuron motor neuron axon decreased length , abnormal
motor neuron axon microtubule bundle decreased diameter , abnormal
motor neuron axon microtubule bundle decreased diameter , ameliorated
Show

 ZFA:0009244 primary motor neuron primary motor neuron axonogenesis process quality , abnormal
primary motor neuron axon morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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