ENSDARG00000025011


Danio rerio

Features
Gene ID: ENSDARG00000025011
  
Biological name :synj1
  
Synonyms : synaptojanin 1 / synj1
  
Possible biological names infered from orthology : O43426
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 26515946
Gene end: 26569350
  
Corresponding Affymetrix probe sets: Dr.7683.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000122252
NCBI entrez gene - 337236     See in Manteia.
swissprot - E9QHF3
ZFIN ID - ZDB-GENE-030131-9180
Ensembl - ENSDARG00000025011
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SYNJ1ENSGALG00000034317Gallus gallus
 SYNJ1ENSG00000159082Homo sapiens
 Synj1ENSMUSG00000022973Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
inpp5b / inositol polyphosphate-5-phosphatase B / P32019* / Q8K337* / Type II inositol 1,4,5-trisphosphate 5-phosphatase *ENSDARG0000010368315
ocrl / oculocerebrorenal syndrome of Lowe / Q01968* / Q6NVF0* / OCRL, inositol polyphosphate-5-phosphatase* / Inositol polyphosphate 5-phosphatase OCRL-1 *ENSDARG0000007810614
inppl1b / inositol polyphosphate phosphatase-like 1bENSDARG0000000144212
inpp5d / inositol polyphosphate-5-phosphatase D / Q92835* / Q9ES52* / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 *ENSDARG0000007428312
inpp5ja / inositol polyphosphate-5-phosphatase Ja / INPP5J* / P59644* / Q15735* / inositol polyphosphate-5-phosphatase J* / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A *ENSDARG0000007854210
inpp5e / inositol polyphosphate-5-phosphatase E / Q9JII1* / Q9NRR6* / 72 kDa inositol polyphosphate 5-phosphatase *ENSDARG0000010392610
inpp5jb / inositol polyphosphate-5-phosphatase Jb / INPP5J* / P59644* / Q15735* / inositol polyphosphate-5-phosphatase J* / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A *ENSDARG000000933599
inppl1a / inositol polyphosphate phosphatase-like 1a / INPPL1* / O15357* / Q6P549* / inositol polyphosphate phosphatase like 1* / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 *ENSDARG000001042229
inpp5kb / inositol polyphosphate-5-phosphatase Kb / INPP5K* / Q9BT40* / Q8C5L6* / inositol polyphosphate-5-phosphatase K*ENSDARG000000786188
inpp5ka / inositol polyphosphate-5-phosphatase Ka / INPP5K* / Q9BT40* / Q8C5L6* / inositol polyphosphate-5-phosphatase K*ENSDARG000000995638


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR000504  RNA recognition motif domain
 IPR002013  SAC domain
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR015047  Domain of unknown function DUF1866
 IPR034971  Synaptojanin-1, RNA recognition motif
 IPR034972  Synaptojanin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0009584 detection of visible light IMP
 biological_processGO:0046549 retinal cone cell development IMP
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0048488 synaptic vesicle endocytosis IEA
 biological_processGO:0050808 synapse organization IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0099518 vesicle cytoskeletal trafficking IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034595 phosphatidylinositol phosphate 5-phosphatase activity IDA
 molecular_functionGO:0034596 phosphatidylinositol phosphate 4-phosphatase activity IDA
 molecular_functionGO:0042578 phosphoric ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of IP3 and IP4 in the cytosol
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye quality , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0009127 photoreceptor cell photoreceptor cell ribbon synapse malformed , abnormal
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 ZFA:0009262 retinal cone cell retinal cone cell autophagy process quality , abnormal
retinal cone cell autophagosome increased amount , abnormal
retinal cone cell endosomal transport process quality , abnormal
retinal cone cell late endosome morphology , abnormal
retinal cone cell late endosome increased size , abnormal
retinal cone cell photoreceptor inner segment physical object quality , abnormal
retinal cone cell axon terminus morphology , abnormal
retinal cone cell photoreceptor inner segment has extra parts of type retinal cone cell cytoplasmic vesicle, abnormal
retinal cone cell lysosome organization process quality , abnormal
retinal cone cell Golgi apparatus morphology , abnormal
retinal cone cell Golgi apparatus disorganized , abnormal
retinal cone cell Golgi apparatus broken , abnormal
retinal cone cell maintenance of Golgi location decreased process quality , abnormal
Show

 ZFA:0009367 neuromast hair cell neuromast hair cell plasma membrane protruding , abnormal
neuromast hair cell synaptic vesicle amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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