ENSDARG00000103926


Danio rerio

Features
Gene ID: ENSDARG00000103926
  
Biological name :inpp5e
  
Synonyms : inositol polyphosphate-5-phosphatase E / inpp5e
  
Possible biological names infered from orthology : 72 kDa inositol polyphosphate 5-phosphatase / Q9JII1 / Q9NRR6
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 65065968
Gene end: 65082107
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000135950
Ensembl peptide - ENSDARP00000137223
NCBI entrez gene - 606579     See in Manteia.
RefSeq - NM_001102619
RefSeq Peptide - NP_001096089
swissprot - A0A0R4ISZ8
swissprot - A0A0R4INV4
ZFIN ID - ZDB-GENE-050809-23
Ensembl - ENSDARG00000103926
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 INPP5EENSGALG00000001964Gallus gallus
 INPP5EENSG00000148384Homo sapiens
 Inpp5eENSMUSG00000026925Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
synj1 / synaptojanin 1 / O43426*ENSDARG0000002501122
inpp5b / inositol polyphosphate-5-phosphatase B / P32019* / Q8K337* / Type II inositol 1,4,5-trisphosphate 5-phosphatase *ENSDARG0000010368320
inppl1b / inositol polyphosphate phosphatase-like 1bENSDARG0000000144219
inpp5d / inositol polyphosphate-5-phosphatase D / Q92835* / Q9ES52* / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 *ENSDARG0000007428319
ocrl / oculocerebrorenal syndrome of Lowe / Q01968* / Q6NVF0* / OCRL, inositol polyphosphate-5-phosphatase* / Inositol polyphosphate 5-phosphatase OCRL-1 *ENSDARG0000007810619
inppl1a / inositol polyphosphate phosphatase-like 1a / INPPL1* / O15357* / Q6P549* / inositol polyphosphate phosphatase like 1* / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 *ENSDARG0000010422219
inpp5jb / inositol polyphosphate-5-phosphatase Jb / INPP5J* / P59644* / Q15735* / inositol polyphosphate-5-phosphatase J* / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A *ENSDARG0000009335917
inpp5kb / inositol polyphosphate-5-phosphatase Kb / INPP5K* / Q9BT40* / Q8C5L6* / inositol polyphosphate-5-phosphatase K*ENSDARG0000007861816
inpp5ka / inositol polyphosphate-5-phosphatase Ka / INPP5K* / Q9BT40* / Q8C5L6* / inositol polyphosphate-5-phosphatase K*ENSDARG0000009956316
inpp5ja / inositol polyphosphate-5-phosphatase Ja / INPP5J* / P59644* / Q15735* / inositol polyphosphate-5-phosphatase J* / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A *ENSDARG0000007854215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR005135  Endonuclease/exonuclease/phosphatase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032402 melanosome transport IMP
 biological_processGO:0035850 epithelial cell differentiation involved in kidney development IMP
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:1902017 regulation of cilium assembly IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the Golgi membrane
ARL13B-mediated ciliary trafficking of INPP5E


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle cilium decreased length , abnormal
Kupffers vesicle cilium decreased amount , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct cilium decreased length , abnormal
pronephric duct filamentous actin mislocalised , abnormal
pronephric duct establishment of epithelial cell apical/basal polarity decreased process quality , abnormal
pronephric duct actin filament bundle distribution decreased process quality , abnormal
pronephric duct has number of pronephric duct motile cilium, ameliorated
pronephric duct has fewer parts of type pronephric duct motile cilium, abnormal
pronephric duct 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate mislocalised , abnormal
pronephric duct 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate mislocalised , abnormal
pronephric duct apical plasma membrane absent , abnormal
pronephric duct apical plasma membrane mislocalised , abnormal
pronephric duct ciliary basal body mislocalised , abnormal
pronephric duct cilium assembly occurrence , ameliorated
pronephric duct cilium assembly decreased occurrence , abnormal
pronephric duct ciliary basal body-plasma membrane docking decreased process quality , abnormal
pronephric duct cystic , abnormal
pronephric duct ciliary basal body absent , abnormal
pronephric duct 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate position , ameliorated
pronephric duct apical plasma membrane amount , ameliorated
pronephric duct apical plasma membrane decreased amount , abnormal
pronephric duct establishment of epithelial cell apical/basal polarity process quality , ameliorated
pronephric duct inositol phosphate-mediated signaling process quality , ameliorated
pronephric duct inositol phosphate-mediated signaling decreased process quality , abnormal
pronephric duct 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate position , ameliorated
pronephric duct apical plasma membrane position , ameliorated
Show

 ZFA:0000151 pronephros pronephros renal filtration rate , ameliorated
pronephros renal filtration decreased rate , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus morphology , ameliorated
pronephric glomerulus cystic , abnormal
pronephric glomerulus cystic , exacerbated
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr