ENSDARG00000025350


Danio rerio
activityprdx2antioxidantcelldetoxificationalkylhydroperoxidereductasesubunitcthiolspecificthioredoxin-likefoldthioredoxindomainc-terminalahpc-typeredoxhomeostasisoxidation-reductionprocesscellularoxidantoxidoreductasereactiveoxygenspeciestpregulates

Features
Gene ID: ENSDARG00000025350
  
Biological name :prdx2
  
Synonyms : peroxiredoxin 2 / prdx2
  
Possible biological names infered from orthology : Gm5225 / P32119 / Q61171
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 51721851
Gene end: 51729862
  
Corresponding Affymetrix probe sets: Dr.5684.1.S1_at (Zebrafish Array)   NM_001002468_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000040396
NCBI entrez gene - 791455     See in Manteia.
RefSeq - NM_001002468
RefSeq Peptide - NP_001002468
swissprot - Q6DGJ6
ZFIN ID - ZDB-GENE-030326-2
Ensembl - ENSDARG00000025350
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRDX2ENSG00000167815Homo sapiens
 Gm5225ENSMUSG00000095266Mus musculus
 Prdx2ENSMUSG00000005161Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prdx1 / peroxiredoxin 1 / P35700* / Q06830*ENSDARG0000005873481
prdx4 / peroxiredoxin 4 / O08807* / Q13162*ENSDARG0000006901370
prdx3 / peroxiredoxin 3 / P20108* / P30048* / Thioredoxin-dependent peroxide reductase, mitochondrial *ENSDARG0000003210262


Protein motifs (from Interpro)
Interpro ID Name
 IPR000866  Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
 IPR012336  Thioredoxin-like fold
 IPR013766  Thioredoxin domain
 IPR019479  Peroxiredoxin, C-terminal
 IPR024706  Peroxiredoxin, AhpC-type


Gene Ontology (GO)
regulation of biological qualityoxidation-reduction processresponse to chemicalcellular response to stimulusregulation of biological qualityoxidation-reduction processresponse to chemicalcellular response to stimulusregulation of biological qualityoxidation-reduction processresponse to chemicalcellular response to stimulusregulation of biological qualityoxidation-reduction processresponse to chemicalcellular response to stimulusregulation of biological qualityoxidation-reduction processresponse to chemicalcellular response to stimulusregulation of biological qualityoxidation-reduction processresponse to chemicalcellular response to stimulusregulation of biological qualityoxidation-reduction processresponse to chemicalcellular response to stimulusregulation of biological qualityoxidation-reduction processresponse to chemicalcellular response to stimulusregulation of biological qualityoxidation-reduction processresponse to chemicalcellular response to stimulusregulation of biological qualityoxidation-reduction processresponse to chemicalcellular response to stimulusregulation of biological qualityregulation of biological qualityoxidation-reduction processoxidation-reduction processresponse to chemicalresponse to chemicalcellular response to stimuluscellular response to stimulus
oxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activity
cellcellcellcellcellcellcellcellcellcellcellcell
TypeGO IDTermEv.Code
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0051920 peroxiredoxin activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000031435 zgc:56493 / TXN* / Txn1* / Q6A555* / Q86VQ3* / P10639* / Q69AB2* / TXNDC2* / TXNDC8* / P10599* / thioredoxin* / thioredoxin 1* / thioredoxin domain containing 2* / thioredoxin domain contai...  / reaction
 ENSDARG00000025350 prdx2 / peroxiredoxin 2 / Gm5225* / P32119* / Q61171*  / complex
 ENSDARG00000044125 txn / thioredoxin / Txn1* / Q6A555* / Q86VQ3* / TXNDC8* / P10599* / P10639* / Q69AB2* / TXNDC2* / thioredoxin 1* / thioredoxin domain containing 2* / thioredoxin domain containing 8* / thio...  / reaction






 

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