ENSDARG00000025902


Danio rerio

Features
Gene ID: ENSDARG00000025902
  
Biological name :plekhg5a
  
Synonyms : pleckstrin homology domain containing, family G (with RhoGef domain) member 5a / plekhg5a
  
Possible biological names infered from orthology : O94827 / pleckstrin homology and RhoGEF domain containing G5 / Pleckstrin homology domain-containing family G member 5 / PLEKHG5 / Q66T02
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 24464356
Gene end: 24538860
  
Corresponding Affymetrix probe sets: Dr.9333.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000151784
Ensembl peptide - ENSDARP00000156712
Ensembl peptide - ENSDARP00000155684
Ensembl peptide - ENSDARP00000067077
Ensembl peptide - ENSDARP00000137900
Ensembl peptide - ENSDARP00000141087
Ensembl peptide - ENSDARP00000148236
NCBI entrez gene - 562861     See in Manteia.
RefSeq - XM_009306046
swissprot - A0A0R4IVN0
swissprot - A0A0R4ISX1
swissprot - F1R1Q2
ZFIN ID - ZDB-GENE-060503-766
Ensembl - ENSDARG00000025902
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLEKHG5ENSGALG00000027476Gallus gallus
 O94827ENSG00000171680Homo sapiens
 Q66T02ENSMUSG00000039713Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
plekhg5b / pleckstrin homology domain containing, family G (with RhoGef domain) member 5b / O94827* / PLEKHG5* / pleckstrin homology and RhoGEF domain containing G5*ENSDARG0000010175251
plekhg6 / pleckstrin homology domain containing, family G (with RhoGef domain) member 6 / Q3KR16* / Q8R0J1* / pleckstrin homology and RhoGEF domain containing G6* / Pleckstrin homology doma...ENSDARG0000008605618
plekhg7 / pleckstrin homology domain containing, family G (with RhoGef domain) member 7 / Q6ZR37* / pleckstrin homology and RhoGEF domain containing G7*ENSDARG0000006285512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043534 blood vessel endothelial cell migration IMP
 biological_processGO:0065009 regulation of molecular function IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001052 primordial hindbrain channel primordial hindbrain channel dilated , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region kinked , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel truncated , abnormal
intersegmental vessel morphology , abnormal
Show

 ZFA:0005017 primordial midbrain channel primordial midbrain channel dilated , abnormal
Show

 ZFA:0009303 endothelial tip cell endothelial tip cell circular , abnormal
endothelial tip cell filopodium absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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