ENSDARG00000026925


Danio rerio

Features
Gene ID: ENSDARG00000026925
  
Biological name :nos2a
  
Synonyms : nitric oxide synthase 2a, inducible / nos2a
  
Possible biological names infered from orthology : nitric oxide synthase 2 / Nitric oxide synthase, inducible / NOS2 / P29477 / P35228
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 43782267
Gene end: 43796971
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000106851
Ensembl peptide - ENSDARP00000013172
NCBI entrez gene - 404036     See in Manteia.
RefSeq - NM_001104937
RefSeq Peptide - NP_001098407
swissprot - A2BIN8
ZFIN ID - ZDB-GENE-040305-1
Ensembl - ENSDARG00000026925
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOS2ENSGALG00000038096Gallus gallus
 NOS2ENSG00000007171Homo sapiens
 Nos2ENSMUSG00000020826Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nos2b / nitric oxide synthase 2b, inducible / NOS2* / P29477* / P35228* / nitric oxide synthase 2* / Nitric oxide synthase, inducible *ENSDARG0000003197668
nos1 / nitric oxide synthase 1 (neuronal) / Q9Z0J4* / P29475* / nitric oxide synthase 1* / Nitric oxide synthase, brain *ENSDARG0000006891052
pora / P450 (cytochrome) oxidoreductase a / POR* / P16435* / P37040* / cytochrome p450 oxidoreductase* / P450 (cytochrome) oxidoreductase*ENSDARG0000005509217
porb / P450 (cytochrome) oxidoreductase b / POR* / P16435* / P37040* / cytochrome p450 oxidoreductase* / P450 (cytochrome) oxidoreductase*ENSDARG0000005903517


Protein motifs (from Interpro)
Interpro ID Name
 IPR001094  Flavodoxin-like
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR003097  FAD-binding, type 1
 IPR004030  Nitric oxide synthase, N-terminal
 IPR008254  Flavodoxin/nitric oxide synthase
 IPR012144  Nitric-oxide synthase, eukaryote
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029039  Flavoprotein-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006809 nitric oxide biosynthetic process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007263 nitric oxide mediated signal transduction IBA
 biological_processGO:0009611 response to wounding IDA
 biological_processGO:0009749 response to glucose IDA
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IBA
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0045776 negative regulation of blood pressure IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IBA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0003958 NADPH-hemoprotein reductase activity IBA
 molecular_functionGO:0004517 nitric-oxide synthase activity IBA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0010181 FMN binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Nitric oxide stimulates guanylate cyclase
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism decreased life span , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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