ENSDARG00000031976


Danio rerio

Features
Gene ID: ENSDARG00000031976
  
Biological name :nos2b
  
Synonyms : nitric oxide synthase 2b, inducible / nos2b
  
Possible biological names infered from orthology : nitric oxide synthase 2 / Nitric oxide synthase, inducible / NOS2 / P29477 / P35228
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 30323491
Gene end: 30348677
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000048846
NCBI entrez gene - 563654     See in Manteia.
RefSeq - NM_001113501
RefSeq Peptide - NP_001106973
swissprot - F1QML0
ZFIN ID - ZDB-GENE-080916-1
Ensembl - ENSDARG00000031976
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOS2ENSGALG00000038096Gallus gallus
 NOS2ENSG00000007171Homo sapiens
 Nos2ENSMUSG00000020826Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nos2a / nitric oxide synthase 2a, inducible / NOS2* / P29477* / P35228* / nitric oxide synthase 2* / Nitric oxide synthase, inducible *ENSDARG0000002692569
nos1 / nitric oxide synthase 1 (neuronal) / Q9Z0J4* / P29475* / nitric oxide synthase 1* / Nitric oxide synthase, brain *ENSDARG0000006891053
pora / P450 (cytochrome) oxidoreductase a / POR* / P16435* / P37040* / cytochrome p450 oxidoreductase* / P450 (cytochrome) oxidoreductase*ENSDARG0000005509217
porb / P450 (cytochrome) oxidoreductase b / POR* / P16435* / P37040* / cytochrome p450 oxidoreductase* / P450 (cytochrome) oxidoreductase*ENSDARG0000005903517


Protein motifs (from Interpro)
Interpro ID Name
 IPR001094  Flavodoxin-like
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR003097  FAD-binding, type 1
 IPR004030  Nitric oxide synthase, N-terminal
 IPR008254  Flavodoxin/nitric oxide synthase
 IPR012144  Nitric-oxide synthase, eukaryote
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029039  Flavoprotein-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006809 nitric oxide biosynthetic process IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction IBA
 biological_processGO:0009611 response to wounding IDA
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IBA
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0045776 negative regulation of blood pressure IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0090594 inflammatory response to wounding IMP
 biological_processGO:0097755 positive regulation of blood vessel diameter IBA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0003958 NADPH-hemoprotein reductase activity IBA
 molecular_functionGO:0004517 nitric-oxide synthase activity IBA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0010181 FMN binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Nitric oxide stimulates guanylate cyclase
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr